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Entry version 135 (02 Jun 2021)
Sequence version 2 (16 Feb 2004)
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Protein

Reverse gyrase

Gene

rgy

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.

Miscellaneous

This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotation EC:5.6.2.2

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationNote: Binds two Mg2+ per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei89ATPUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi645Magnesium 1; catalyticUniRule annotation1
Metal bindingi771Magnesium 1; catalyticUniRule annotation1
Metal bindingi771Magnesium 2UniRule annotation1
Metal bindingi773Magnesium 2UniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei955For DNA cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri9 – 30C4-type 1UniRule annotationAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi106 – 113ATPUniRule annotation8
Zinc fingeri722 – 741C4-type 2UniRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase, Isomerase, Topoisomerase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PFUR186497:G1FZR-519-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.4.12, 5243
5.6.2.2, 5243

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reverse gyraseUniRule annotation
Including the following 2 domains:
HelicaseUniRule annotation (EC:3.6.4.12UniRule annotation)
TopoisomeraseUniRule annotation (EC:5.6.2.2UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rgyUniRule annotation
Ordered Locus Names:PF0495
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri186497 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001013 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001580891 – 1214Reverse gyraseAdd BLAST1214

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P95479

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P95479, 1 interactor

STRING: functional protein association networks

More...
STRINGi
186497.PF0495

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P95479

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini93 – 252Helicase ATP-bindingUniRule annotationAdd BLAST160
Domaini639 – 802ToprimUniRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni645 – 1214Topoisomerase IAdd BLAST570

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi213 – 216DEAD box4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.UniRule annotation

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.UniRule annotation
In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri9 – 30C4-type 1UniRule annotationAdd BLAST22
Zinc fingeri722 – 741C4-type 2UniRule annotationAdd BLAST20

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG01526, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002886_0_0_2

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVATYYG

Database of Orthologous Groups

More...
OrthoDBi
1837at2157

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00186, TOP1Ac, 1 hit
cd03361, TOPRIM_TopoIA_RevGyr, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.290.10, 1 hit
1.10.460.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01125, Reverse_gyrase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR027417, P-loop_NTPase
IPR005736, Reverse_gyrase
IPR003601, Topo_IA_2
IPR013497, Topo_IA_cen
IPR013824, Topo_IA_cen_sub1
IPR013826, Topo_IA_cen_sub3
IPR023405, Topo_IA_core_domain
IPR003602, Topo_IA_DNA-bd_dom
IPR006171, TOPRIM_domain
IPR034142, TOPRIM_RevGyr
IPR040569, Znf_Rg

The PANTHER Classification System

More...
PANTHERi
PTHR43505, PTHR43505, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF01131, Topoisom_bac, 1 hit
PF01751, Toprim, 1 hit
PF17915, zf_Rg, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00417, PRTPISMRASEI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00437, TOP1Ac, 1 hit
SM00436, TOP1Bc, 1 hit
SM00493, TOPRIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF56712, SSF56712, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01054, rgy, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS50880, TOPRIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P95479-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAIYRDMCP NCRGAITDER LAAKNPCDAC LDEPISMDDY FQLVTAIRKA
60 70 80 90 100
LKLKGVLKEW EEIYALNKEV KEIEELFKKA TGFTFWSAQR SWVKRIIKGK
110 120 130 140 150
SFSIIAPTGM GKSTFGAFMS IYFALKGKKS YIVVPTTPLV VQTVKKIKAM
160 170 180 190 200
MEKAEVKVNL VYYHGNLKKK EKDEALEKIK SGNFDILVTS SQFLATRFDE
210 220 230 240 250
LLKDKRIDFM FVDDVDAFLK ASKNIDRSLM MLGFNEEIIK KAWEIIKLKK
260 270 280 290 300
QLAKLLQNES GNEEVEKLNR EIERLEREIE RYKKENKIGI LIVASATGSA
310 320 330 340 350
RGDRIKLYRE LLGFEVGSGR SVLRNIVDTY IIPEKSMEEH VEELLKTLGR
360 370 380 390 400
GGLIFVPIDK GIEYAEQLTN YLKSKGFKVE LVSARDKKGL ELFEKEEVDY
410 420 430 440 450
LVGVATYYGT IVRGLDLPHL VRFAIFTGVP KFRFSLDLEQ PTIYRVLGLM
460 470 480 490 500
SEILEFLPEE KRTEGEKLYA RLRRLIRNIP QYELMKIEEA LAEGLELEGF
510 520 530 540 550
YNHVLEVFKQ AVEFLREALK DEEVLKKIAE NPFLSLKQIE GKWYIEIPDV
560 570 580 590 600
RTYIQASGRT SRLFAGGITK GLSVILVDDQ KVFNGLIRQM RWRFVEFEIK
610 620 630 640 650
PLGEINIEEV LKEIDRDREK VRLVLEGKIS EQVKDLVKSA LMIVESPNKA
660 670 680 690 700
RTIANFFGQP SKRRIGDLVA YEVSIGDKML TILASGGHMF DLVTTEGYHG
710 720 730 740 750
VLLLEKGGKR YFVPVYDTIK RCRDCGHQFV DWEEKGVCPR CGSRNVYDAL
760 770 780 790 800
ENVKAMRDLA QEVDEILIGT DPDTEGEKIA WDIRNVLSPY APVIKRIEFH
810 820 830 840 850
EVTRPAILRA INEARDINED RVNAQLVRRI EDRWIGFELS QKLWEVFENY
860 870 880 890 900
NLSAGRVQTP VLGWIVQRYK EFTESETDFL GLTLENDITI ILEGVSGDVQ
910 920 930 940 950
EVYVKEVTIE EREINPLPPY TTDAMLQDAS RFLGFSATHT MQLAQDLFEL
960 970 980 990 1000
GLTTYHRTDS IHVSNTGIEI AKEYITQEIG EEYFAPRKWG EEGAHEAIRP
1010 1020 1030 1040 1050
TRPIDTGRLI QLIRDGIITL PRNLTKDHFK LYDLIFRRFM ASQMKPAKVL
1060 1070 1080 1090 1100
YERAVIGTPY GEVEIEGYID VIYDGWSRIK PLPLKKLPRL EKDQILKVTE
1110 1120 1130 1140 1150
IRKWRAPKVS LYTQGDVIAL MKERGIGRPS TYAKIVQTLL QRGYVIETKS
1160 1170 1180 1190 1200
KKKLVPTEKG IKVYHYLVSK YKDLVSEERT RQLEKLMDMV EEAKANYQEV
1210
LNELYEEILR YVKS
Length:1,214
Mass (Da):139,984
Last modified:February 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B854F084C254EE6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti280E → D in AAB49283 (PubMed:9045834).Curated1
Sequence conflicti937A → P in AAB49283 (PubMed:9045834).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U66557 Genomic DNA Translation: AAB49283.1
AE009950 Genomic DNA Translation: AAL80619.1

NCBI Reference Sequences

More...
RefSeqi
WP_011011612.1, NZ_CP023154.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL80619; AAL80619; PF0495

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41712297

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfu:PF0495

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|186497.12.peg.518

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66557 Genomic DNA Translation: AAB49283.1
AE009950 Genomic DNA Translation: AAL80619.1
RefSeqiWP_011011612.1, NZ_CP023154.1

3D structure databases

SMRiP95479
ModBaseiSearch...

Protein-protein interaction databases

IntActiP95479, 1 interactor
STRINGi186497.PF0495

Proteomic databases

PRIDEiP95479

Genome annotation databases

EnsemblBacteriaiAAL80619; AAL80619; PF0495
GeneIDi41712297
KEGGipfu:PF0495
PATRICifig|186497.12.peg.518

Phylogenomic databases

eggNOGiarCOG01526, Archaea
HOGENOMiCLU_002886_0_0_2
OMAiGVATYYG
OrthoDBi1837at2157

Enzyme and pathway databases

BioCyciPFUR186497:G1FZR-519-MONOMER
BRENDAi3.6.4.12, 5243
5.6.2.2, 5243

Family and domain databases

CDDicd00186, TOP1Ac, 1 hit
cd03361, TOPRIM_TopoIA_RevGyr, 1 hit
Gene3Di1.10.290.10, 1 hit
1.10.460.10, 1 hit
HAMAPiMF_01125, Reverse_gyrase, 1 hit
InterProiView protein in InterPro
IPR011545, DEAD/DEAH_box_helicase_dom
IPR014001, Helicase_ATP-bd
IPR027417, P-loop_NTPase
IPR005736, Reverse_gyrase
IPR003601, Topo_IA_2
IPR013497, Topo_IA_cen
IPR013824, Topo_IA_cen_sub1
IPR013826, Topo_IA_cen_sub3
IPR023405, Topo_IA_core_domain
IPR003602, Topo_IA_DNA-bd_dom
IPR006171, TOPRIM_domain
IPR034142, TOPRIM_RevGyr
IPR040569, Znf_Rg
PANTHERiPTHR43505, PTHR43505, 1 hit
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF01131, Topoisom_bac, 1 hit
PF01751, Toprim, 1 hit
PF17915, zf_Rg, 1 hit
PRINTSiPR00417, PRTPISMRASEI
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00437, TOP1Ac, 1 hit
SM00436, TOP1Bc, 1 hit
SM00493, TOPRIM, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF56712, SSF56712, 1 hit
TIGRFAMsiTIGR01054, rgy, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS50880, TOPRIM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGYR_PYRFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P95479
Secondary accession number(s): Q8U3H2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: June 2, 2021
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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