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Protein

Aromatic-amino-acid aminotransferase

Gene

tyrB

Organism
Paracoccus denitrificans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Shows activities toward both dicarboxylic and aromatic substrates.

Catalytic activityi

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34Substrate; via amide nitrogen1
Binding sitei65Substrate1
Binding sitei127Substrate1
Binding sitei180Substrate1
Binding sitei371Substrate1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BRENDAi2.6.1.57 3341

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatic-amino-acid aminotransferase (EC:2.6.1.57)
Short name:
ARAT
Short name:
AROAT
Gene namesi
Name:tyrB
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB03400 3-(P-Tolyl)Propionic Acid
DB02740 3-Indolebutyric Acid
DB02024 3-phenylpropionic acid
DB02434 4-(2-Thienyl)Butyric Acid
DB03210 4-Aminohydrocinnamic Acid
DB04051 5-Phenylvaleric Acid
DB02242 Cyclohexane Propionic Acid
DB02000 Gamma-Phenyl-Butyric Acid
DB02758 Indolylpropionic Acid
DB04299 Maleic Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001238941 – 394Aromatic-amino-acid aminotransferaseAdd BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei243N6-(pyridoxal phosphate)lysine1

Proteomic databases

PRIDEiP95468

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1394
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Helixi13 – 22Combined sources10
Helixi47 – 59Combined sources13
Helixi72 – 83Combined sources12
Helixi84 – 86Combined sources3
Helixi89 – 91Combined sources3
Beta strandi92 – 98Combined sources7
Helixi99 – 114Combined sources16
Beta strandi120 – 125Combined sources6
Helixi128 – 137Combined sources10
Beta strandi141 – 145Combined sources5
Turni149 – 152Combined sources4
Helixi156 – 164Combined sources9
Beta strandi171 – 178Combined sources8
Turni180 – 182Combined sources3
Helixi188 – 201Combined sources14
Beta strandi204 – 209Combined sources6
Beta strandi214 – 216Combined sources3
Helixi218 – 231Combined sources14
Beta strandi233 – 240Combined sources8
Turni242 – 246Combined sources5
Helixi248 – 250Combined sources3
Beta strandi252 – 258Combined sources7
Helixi262 – 277Combined sources16
Beta strandi280 – 282Combined sources3
Helixi286 – 296Combined sources11
Helixi298 – 330Combined sources33
Beta strandi331 – 333Combined sources3
Turni334 – 336Combined sources3
Helixi337 – 340Combined sources4
Beta strandi343 – 347Combined sources5
Helixi352 – 362Combined sources11
Beta strandi371 – 373Combined sources3
Helixi374 – 376Combined sources3
Turni379 – 381Combined sources3
Helixi382 – 392Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AY4X-ray2.33A/B1-394[»]
1AY5X-ray2.50A/B1-394[»]
1AY8X-ray2.30A/B1-394[»]
2AY1X-ray2.20A/B1-394[»]
2AY2X-ray2.40A/B1-394[»]
2AY3X-ray2.40A/B1-394[»]
2AY4X-ray2.20A/B1-394[»]
2AY5X-ray2.40A/B1-394[»]
2AY6X-ray2.20A/B1-394[»]
2AY7X-ray2.40A/B1-394[»]
2AY8X-ray2.20A/B1-394[»]
2AY9X-ray2.50A/B1-394[»]
ProteinModelPortaliP95468
SMRiP95468
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP95468

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CGF Bacteria
COG1448 LUCA

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

P95468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGNLKPQAP DKILALMGEF RADPRQGKID LGVGVYKDAT GHTPIMRAVH
60 70 80 90 100
AAEQRMLETE TTKTYAGLSG EPEFQKAMGE LILGDGLKSE TTATLATVGG
110 120 130 140 150
TGALRQALEL ARMANPDLRV FVSDPTWPNH VSIMNFMGLP VQTYRYFDAE
160 170 180 190 200
TRGVDFEGMK ADLAAAKKGD MVLLHGCCHN PTGANLTLDQ WAEIASILEK
210 220 230 240 250
TGALPLIDLA YQGFGDGLEE DAAGTRLIAS RIPEVLIAAS CSKNFGIYRE
260 270 280 290 300
RTGCLLALCA DAATRELAQG AMAFLNRQTY SFPPFHGAKI VSTVLTTPEL
310 320 330 340 350
RADWMAELEA VRSGMLRLRE QLAGELRDLS GSDRFGFVAE HRGMFSRLGA
360 370 380 390
TPEQVKRIKE EFGIYMVGDS RINIAGLNDN TIPILARAII EVGV
Length:394
Mass (Da):42,732
Last modified:May 1, 1997 - v1
Checksum:i092FC4643F1E387A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08272 Genomic DNA Translation: CAA69597.1
PIRiJC5197
RefSeqiWP_011746975.1, NZ_PPGA01000002.1

Similar proteinsi

Entry informationi

Entry nameiTYRB_PARDE
AccessioniPrimary (citable) accession number: P95468
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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