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UniProtKB - P94842 (YBGC_HELPY)
Protein
Acyl-CoA thioesterase YbgC
Gene
ybgC
Organism
Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
Status
Functioni
Thioesterase that may be involved in phospholipid metabolism. Displays acyl-CoA thioesterase activity with lauroyl-CoA (C12:0), myristoyl-CoA (C14:0), palmitoyl-CoA (C16:0), stearoyl-CoA (C18:0) and benzoyl-CoA, catalyzing the hydrolysis of the thioester bond. Has low activity with butyryl-CoA and octanoyl-CoA.
1 PublicationKineticsi
kcat is 0.028 sec(-1) with benzoyl-CoA, 0.034 sec(-1) with stearoyl-CoA, 0.045 sec(-1) with palmitoyl-CoA, 0.024 sec(-1) with myristoyl-CoA, 0.015 sec(-1) with lauroyl-CoA and 0.0013 sec(-1) with octanoyl-CoA.
- KM=200 µM for benzoyl-CoA
- KM=210 µM for stearoyl-CoA
- KM=570 µM for palmitoyl-CoA
- KM=240 µM for myristoyl-CoA
- KM=160 µM for lauroyl-CoA
- KM=40 µM for octanoyl-CoA
- KM=27 µM for butyryl-CoA
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 11 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- acyl-CoA hydrolase activity Source: GO_Central
GO - Biological processi
- lipid metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid metabolism |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ybgC Ordered Locus Names:HP_0496 |
Organismi | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori) |
Taxonomic identifieri | 85962 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Helicobacter › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087767 | 1 – 133 | Acyl-CoA thioesterase YbgCAdd BLAST | 133 |
Proteomic databases
PaxDbi | P94842 |
Interactioni
Subunit structurei
Homotetramer. May interact with CagA.
1 PublicationBinary interactionsi
P94842
With | #Exp. | IntAct |
---|---|---|
cagA [P55980] | 2 | EBI-528090,EBI-528104 |
Protein-protein interaction databases
DIPi | DIP-3437N |
IntActi | P94842, 1 interactor |
MINTi | P94842 |
STRINGi | 85962.C694_02550 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P94842 |
SMRi | P94842 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P94842 |
Family & Domainsi
Sequence similaritiesi
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.Curated
Phylogenomic databases
eggNOGi | COG0824, Bacteria |
OMAi | FPIRVYW |
PhylomeDBi | P94842 |
Family and domain databases
InterProi | View protein in InterPro IPR008272, HB-CoA_thioesterase_AS IPR029069, HotDog_dom_sf IPR006683, Thioestr_dom IPR006684, YbgC/YbaW |
Pfami | View protein in Pfam PF03061, 4HBT, 1 hit |
PIRSFi | PIRSF003230, YbgC, 1 hit |
SUPFAMi | SSF54637, SSF54637, 1 hit |
TIGRFAMsi | TIGR00051, TIGR00051, 1 hit |
PROSITEi | View protein in PROSITE PS01328, 4HBCOA_THIOESTERASE, 1 hit |
i Sequence
Sequence statusi: Complete.
P94842-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRCRVYYEDT DSEGVVYHAN YLKYCERARS EFFFKQNVLP ENEEGVFVIR
60 70 80 90 100
SIKADFFTPA SLGQVLEIRT QIKELRKVFV VLFQEIYCIQ NASLEPMKPF
110 120 130
KVFASEIKFG FVNRSTYSPI AIPKLFKELL NAI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 133 | I → V in AAB39716 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75328 Genomic DNA Translation: AAB39716.1 AE000511 Genomic DNA Translation: AAD07561.1 |
PIRi | H64581 |
RefSeqi | NP_207293.1, NC_000915.1 WP_001203797.1, NC_018939.1 |
Genome annotation databases
EnsemblBacteriai | AAD07561; AAD07561; HP_0496 |
KEGGi | hpy:HP_0496 |
PATRICi | fig|85962.47.peg.534 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U75328 Genomic DNA Translation: AAB39716.1 AE000511 Genomic DNA Translation: AAD07561.1 |
PIRi | H64581 |
RefSeqi | NP_207293.1, NC_000915.1 WP_001203797.1, NC_018939.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PZH | X-ray | 1.70 | A/B/C/D | 1-133 | [»] | |
AlphaFoldDBi | P94842 | |||||
SMRi | P94842 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-3437N |
IntActi | P94842, 1 interactor |
MINTi | P94842 |
STRINGi | 85962.C694_02550 |
Proteomic databases
PaxDbi | P94842 |
Genome annotation databases
EnsemblBacteriai | AAD07561; AAD07561; HP_0496 |
KEGGi | hpy:HP_0496 |
PATRICi | fig|85962.47.peg.534 |
Phylogenomic databases
eggNOGi | COG0824, Bacteria |
OMAi | FPIRVYW |
PhylomeDBi | P94842 |
Miscellaneous databases
EvolutionaryTracei | P94842 |
Family and domain databases
InterProi | View protein in InterPro IPR008272, HB-CoA_thioesterase_AS IPR029069, HotDog_dom_sf IPR006683, Thioestr_dom IPR006684, YbgC/YbaW |
Pfami | View protein in Pfam PF03061, 4HBT, 1 hit |
PIRSFi | PIRSF003230, YbgC, 1 hit |
SUPFAMi | SSF54637, SSF54637, 1 hit |
TIGRFAMsi | TIGR00051, TIGR00051, 1 hit |
PROSITEi | View protein in PROSITE PS01328, 4HBCOA_THIOESTERASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YBGC_HELPY | |
Accessioni | P94842Primary (citable) accession number: P94842 Secondary accession number(s): O25238 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 15, 1999 | |
Last modified: | May 25, 2022 | |
This is version 126 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families