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Entry version 142 (29 Sep 2021)
Sequence version 2 (01 Jul 1997)
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Protein

Endonuclease MutS2

Gene

mutSB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.

UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi335 – 342ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU28580-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease MutS2UniRule annotation (EC:3.1.-.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mutSB
Synonyms:mutS2, yshD
Ordered Locus Names:BSU28580
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001152171 – 785Endonuclease MutS2Add BLAST785

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P94545

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224308.BSU28580

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P94545

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini710 – 785SmrUniRule annotationAdd BLAST76

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1193, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P94545

Identification of Orthologs from Complete Genome Data

More...
OMAi
IHAIIND

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P94545

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03280, ABC_MutS2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00092, MutS2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000432, DNA_mismatch_repair_MutS_C
IPR007696, DNA_mismatch_repair_MutS_core
IPR036187, DNA_mismatch_repair_MutS_sf
IPR005747, MutS2
IPR027417, P-loop_NTPase
IPR002625, Smr_dom
IPR036063, Smr_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11361:SF14, PTHR11361:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00488, MutS_V, 1 hit
PF01713, Smr, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005814, MutS_YshD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00463, SMR, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF160443, SSF160443, 1 hit
SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01069, mutS2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50828, SMR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P94545-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQKVLSALE FHKVKEQVIG HAASSLGKEM LLELKPSASI DEIKKQLDEV
60 70 80 90 100
DEASDIIRLR GQAPFGGLVD IRGALRRAEI GSVLSPSEFT EISGLLYAVK
110 120 130 140 150
QMKHFITQMA EDGVDIPLIH QHAEQLITLS DLERDINSCI DDHGEVLDHA
160 170 180 190 200
SETLRGIRTQ LRTLESRVRD RLESMLRSSS ASKMLSDTIV TIRNDRFVIP
210 220 230 240 250
VKQEYRSSYG GIVHDTSSSG ATLFIEPQAI VDMNNSLQQA KVKEKQEIER
260 270 280 290 300
ILRVLTEKTA EYTEELFLDL QVLQTLDFIF AKARYAKAVK ATKPIMNDTG
310 320 330 340 350
FIRLKKARHP LLPPDQVVAN DIELGRDFST IVITGPNTGG KTVTLKTLGL
360 370 380 390 400
LTLMAQSGLH IPADEGSEAA VFEHVFADIG DEQSIEQSLS TFSSHMVNIV
410 420 430 440 450
GILEQVNENS LVLFDELGAG TDPQEGAALA MSILDDVHRT NARVLATTHY
460 470 480 490 500
PELKAYGYNR EGVMNASVEF DIETLSPTYK LLIGVPGRSN AFEISKRLGL
510 520 530 540 550
PDHIIGQAKS EMTAEHNEVD TMIASLEQSK KRAEEELSET ESIRKEAEKL
560 570 580 590 600
HKELQQQIIE LNSKKDKMLE EAEQQAAEKV KAAMKEAEDI IHELRTIKEE
610 620 630 640 650
HKSFKDHELI NAKKRLEGAM PAFEKSKKPE KPKTQKRDFK PGDEVKVLTF
660 670 680 690 700
GQKGTLLEKT GGNEWNVQIG ILKMKVKEKD LEFIKSAPEP KKEKMITAVK
710 720 730 740 750
GKDYHVSLEL DLRGERYENA LSRVEKYLDD AVLAGYPRVS IIHGKGTGAL
760 770 780
RKGVQDLLKN HRSVKSSRFG EAGEGGSGVT VVELK
Length:785
Mass (Da):87,417
Last modified:July 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20D14CDB931167C2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z75208 Genomic DNA Translation: CAA99569.1
AL009126 Genomic DNA Translation: CAB14818.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D69985

NCBI Reference Sequences

More...
RefSeqi
NP_390736.1, NC_000964.3
WP_003229541.1, NZ_JNCM01000036.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB14818; CAB14818; BSU_28580

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
937447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU28580

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.3105

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z75208 Genomic DNA Translation: CAA99569.1
AL009126 Genomic DNA Translation: CAB14818.1
PIRiD69985
RefSeqiNP_390736.1, NC_000964.3
WP_003229541.1, NZ_JNCM01000036.1

3D structure databases

SMRiP94545
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224308.BSU28580

Proteomic databases

PaxDbiP94545

Genome annotation databases

EnsemblBacteriaiCAB14818; CAB14818; BSU_28580
GeneIDi937447
KEGGibsu:BSU28580
PATRICifig|224308.179.peg.3105

Phylogenomic databases

eggNOGiCOG1193, Bacteria
InParanoidiP94545
OMAiIHAIIND
PhylomeDBiP94545

Enzyme and pathway databases

BioCyciBSUB:BSU28580-MONOMER

Family and domain databases

CDDicd03280, ABC_MutS2, 1 hit
Gene3Di3.40.50.300, 1 hit
HAMAPiMF_00092, MutS2, 1 hit
InterProiView protein in InterPro
IPR000432, DNA_mismatch_repair_MutS_C
IPR007696, DNA_mismatch_repair_MutS_core
IPR036187, DNA_mismatch_repair_MutS_sf
IPR005747, MutS2
IPR027417, P-loop_NTPase
IPR002625, Smr_dom
IPR036063, Smr_dom_sf
PANTHERiPTHR11361:SF14, PTHR11361:SF14, 1 hit
PfamiView protein in Pfam
PF00488, MutS_V, 1 hit
PF01713, Smr, 1 hit
PIRSFiPIRSF005814, MutS_YshD, 1 hit
SMARTiView protein in SMART
SM00534, MUTSac, 1 hit
SM00533, MUTSd, 1 hit
SM00463, SMR, 1 hit
SUPFAMiSSF160443, SSF160443, 1 hit
SSF48334, SSF48334, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01069, mutS2, 1 hit
PROSITEiView protein in PROSITE
PS00486, DNA_MISMATCH_REPAIR_2, 1 hit
PS50828, SMR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMUTS2_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P94545
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: September 29, 2021
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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