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Protein

Phospholipase D alpha 2

Gene

PLD2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Plays an important role in various cellular processes.

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei338PROSITE-ProRule annotation1
Active sitei340PROSITE-ProRule annotation1
Active sitei345PROSITE-ProRule annotation1
Active sitei668PROSITE-ProRule annotation1
Active sitei670PROSITE-ProRule annotation1
Active sitei675PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism
LigandCalcium

Enzyme and pathway databases

ReactomeiR-OSA-1483166 Synthesis of PA
R-OSA-2029485 Role of phospholipids in phagocytosis
R-OSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D alpha 2 (EC:3.1.4.4)
Short name:
PLD alpha 2
Alternative name(s):
Choline phosphatase 2
Phosphatidylcholine-hydrolyzing phospholipase D 2
Gene namesi
Name:PLD2
Ordered Locus Names:Os06g0604400Imported, LOC_Os06g40190Curated
ORF Names:OsJ_21907Imported, P0481H08.5
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188211 – 817Phospholipase D alpha 2Add BLAST817

Proteomic databases

PaxDbiP93844
PRIDEiP93844

Expressioni

Gene expression databases

ExpressionAtlasiP93844 differential
GenevisibleiP93844 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g40190.1

Structurei

3D structure databases

ProteinModelPortaliP93844
SMRiP93844
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 114C2Add BLAST114
Domaini333 – 372PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST40
Domaini663 – 690PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Domaini

C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. A lower affinity toward calcium can be anticipated for PLD alpha due to the absence of two potential calcium ligands.

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1329 Eukaryota
COG1502 LUCA
HOGENOMiHOG000240112
InParanoidiP93844
KOiK01115
OMAiGEHFAVY
OrthoDBiEOG093601XZ

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001736 PLipase_D/transphosphatidylase
IPR024632 PLipase_D_C
IPR015679 PLipase_D_fam
IPR011402 PLipase_D_pln
PANTHERiPTHR18896 PTHR18896, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12357 PLD_C, 1 hit
PF00614 PLDc, 2 hits
PIRSFiPIRSF036470 PLD_plant, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

P93844-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHLLLHGTL EATILEADHL SNPTRATGAA PGIFRKFVEG FEDSLGLGKG
60 70 80 90 100
ATRLYATIDL GRARVGRTRV VDDEPVNPRW YEVFHIYCAH FAADVVFSVK
110 120 130 140 150
AAQPIGATLI GRAYLPVREL LSGEAIERRL DILDAGRRRI SHGPTIHVRL
160 170 180 190 200
QFRDVAGDRH GWGRGVSGAR YPGVPYTFFS QRPGCRVTLY QDAHVPDAFA
210 220 230 240 250
PRIPLAGGGY YRQGRCWEDV FDAISNAKHL IYLTGWSVYT EITLIRDGTR
260 270 280 290 300
QRPGGDATLG ELLKRKASEG VRVLLLVWDD RTSVESLGMK WGFMSTHDAE
310 320 330 340 350
TADYFRGTDV RCVLCPRNPD AGRSAIMGAQ IAYMITHHQK TVIVDHDMPV
360 370 380 390 400
PRGGGSRRIV SFVGGLDLCD GRYDTQFHSL FRTLDTAHHS DFHQPNLDGA
410 420 430 440 450
AVTKGGPREP WHDIHSKIEG PAAWDVLYNF EQRWRKQGGD KDLLLDLKAM
460 470 480 490 500
ADLIIPPSPV MFPDDGEAWS VQLFRSIDGG ACFGFPSTPE AAARSGLVSG
510 520 530 540 550
KNNTIDRSIQ DAYIHAIRRA KNFIYIENQY FLGSSFAWKA DGIRPEDIEA
560 570 580 590 600
LHLIPREISL KIVNKIEAGE RFAVYVVLPM WPEGPPASGS VQAILDWQRR
610 620 630 640 650
TMEMMYYDIA VALEAKRINA DPRDYLTFFC LGNREVKLNG EYEPAGRPLD
660 670 680 690 700
GTDYAKAQKA RRFMIYVHSK MMIVDDEYII VGSANINQRS MDGGRDSEIA
710 720 730 740 750
MGAFQPCHLN TKGLVARGQI HGFRMSLWYE HLGMLHDNFL NPESLECVQR
760 770 780 790 800
VNKMADKYWD LYASDELNDD LPGHLLTYPV RVTKEGTVTE LPGAKFFPDT
810
QAPVIGTKGN LPPFLTT
Length:817
Mass (Da):91,319
Last modified:June 13, 2006 - v2
Checksum:i948AE6A40B32E12F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111G → D in BAA19466 (Ref. 1) Curated1
Sequence conflicti122S → C in BAA19466 (Ref. 1) Curated1
Sequence conflicti365G → R in BAA19466 (Ref. 1) Curated1
Sequence conflicti387A → G in BAA19466 (Ref. 1) Curated1
Sequence conflicti391D → Y in BAA19466 (Ref. 1) Curated1
Sequence conflicti395P → A in BAA19466 (Ref. 1) Curated1
Sequence conflicti480G → WA in BAA19466 (Ref. 1) Curated1
Sequence conflicti520A → R in BAA19466 (Ref. 1) Curated1
Sequence conflicti550A → P in BAA19466 (Ref. 1) Curated1
Sequence conflicti690S → P in BAA19466 (Ref. 1) Curated1
Sequence conflicti694 – 695GR → EG in BAA19466 (Ref. 1) Curated2
Sequence conflicti729Y → F in AK072121 (PubMed:12869764).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001919 Genomic DNA Translation: BAA19466.1
AP003629 Genomic DNA Translation: BAD35531.1
AP008212 Genomic DNA Translation: BAF19931.1
AP014962 Genomic DNA Translation: BAS98517.1
CM000143 Genomic DNA Translation: EEE65982.1
AK072121 mRNA No translation available.
PIRiT03401
RefSeqiXP_015643893.1, XM_015788407.1
UniGeneiOs.9878

Genome annotation databases

EnsemblPlantsiOs06t0604400-01; Os06t0604400-01; Os06g0604400
GeneIDi4341469
GrameneiOs06t0604400-01; Os06t0604400-01; Os06g0604400
KEGGiosa:4341469

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001919 Genomic DNA Translation: BAA19466.1
AP003629 Genomic DNA Translation: BAD35531.1
AP008212 Genomic DNA Translation: BAF19931.1
AP014962 Genomic DNA Translation: BAS98517.1
CM000143 Genomic DNA Translation: EEE65982.1
AK072121 mRNA No translation available.
PIRiT03401
RefSeqiXP_015643893.1, XM_015788407.1
UniGeneiOs.9878

3D structure databases

ProteinModelPortaliP93844
SMRiP93844
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os06g40190.1

Proteomic databases

PaxDbiP93844
PRIDEiP93844

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOs06t0604400-01; Os06t0604400-01; Os06g0604400
GeneIDi4341469
GrameneiOs06t0604400-01; Os06t0604400-01; Os06g0604400
KEGGiosa:4341469

Phylogenomic databases

eggNOGiKOG1329 Eukaryota
COG1502 LUCA
HOGENOMiHOG000240112
InParanoidiP93844
KOiK01115
OMAiGEHFAVY
OrthoDBiEOG093601XZ

Enzyme and pathway databases

ReactomeiR-OSA-1483166 Synthesis of PA
R-OSA-2029485 Role of phospholipids in phagocytosis
R-OSA-6798695 Neutrophil degranulation

Gene expression databases

ExpressionAtlasiP93844 differential
GenevisibleiP93844 OS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001736 PLipase_D/transphosphatidylase
IPR024632 PLipase_D_C
IPR015679 PLipase_D_fam
IPR011402 PLipase_D_pln
PANTHERiPTHR18896 PTHR18896, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF12357 PLD_C, 1 hit
PF00614 PLDc, 2 hits
PIRSFiPIRSF036470 PLD_plant, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPLDA2_ORYSJ
AccessioniPrimary (citable) accession number: P93844
Secondary accession number(s): A0A0P0WYW9, Q0DB42, Q69X20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: June 13, 2006
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
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