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Protein

4-hydroxyphenylpyruvate dioxygenase

Gene

HPD

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.

Cofactori

Fe cation1 PublicationNote: Binds 1 Fe cation per subunit.1 Publication

Pathwayi: L-phenylalanine degradation

This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Tyrosine aminotransferase (TAT)
  3. 4-hydroxyphenylpyruvate dioxygenase (HPD)
  4. Homogentisate 1,2-dioxygenase (HGO)
  5. no protein annotated in this organism
  6. Fumarylacetoacetase (FAH)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Pathwayi: prenylquinone biosynthesis

This protein is involved in the pathway prenylquinone biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway prenylquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi226Iron1 Publication1
Metal bindingi308Iron1 Publication1
Metal bindingi394Iron1 Publication1

GO - Molecular functioni

  • 4-hydroxyphenylpyruvate dioxygenase activity Source: GO_Central
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.27 399
ReactomeiR-ATH-71182 Phenylalanine and tyrosine catabolism
SABIO-RKiP93836
UniPathwayi
UPA00139;UER00362

UPA00975

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)
Alternative name(s):
4-hydroxyphenylpyruvic acid oxidase
Short name:
4HPPD
Short name:
HPD
Short name:
HPPDase
Gene namesi
Name:HPD
Synonyms:PDS1
Ordered Locus Names:At1g06570
ORF Names:F12K11.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G06570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2242740

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000883971 – 4454-hydroxyphenylpyruvate dioxygenaseAdd BLAST445

Proteomic databases

PaxDbiP93836
PRIDEiP93836

PTM databases

iPTMnetiP93836

Expressioni

Gene expression databases

ExpressionAtlasiP93836 baseline and differential
GenevisibleiP93836 AT

Interactioni

Subunit structurei

Homodimer.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1251387,EBI-1251387

GO - Molecular functioni

Protein-protein interaction databases

STRINGi3702.AT1G06570.1

Structurei

Secondary structure

1445
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP93836
SMRiP93836
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP93836

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 192VOC 1PROSITE-ProRule annotationAdd BLAST147
Domaini223 – 383VOC 2PROSITE-ProRule annotationAdd BLAST161

Sequence similaritiesi

Belongs to the 4HPPD family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0638 Eukaryota
COG3185 LUCA
InParanoidiP93836
KOiK00457
OMAiMVGNVGW
OrthoDBiEOG09360BAR
PhylomeDBiP93836

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR005956 4OHPhenylPyrv_dOase
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PANTHERiPTHR11959 PTHR11959, 1 hit
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
PIRSFiPIRSF009283 HPP_dOase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR01263 4HPPD, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P93836-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHQNAAVSE NQNHDDGAAS SPGFKLVGFS KFVRKNPKSD KFKVKRFHHI
60 70 80 90 100
EFWCGDATNV ARRFSWGLGM RFSAKSDLST GNMVHASYLL TSGDLRFLFT
110 120 130 140 150
APYSPSLSAG EIKPTTTASI PSFDHGSCRS FFSSHGLGVR AVAIEVEDAE
160 170 180 190 200
SAFSISVANG AIPSSPPIVL NEAVTIAEVK LYGDVVLRYV SYKAEDTEKS
210 220 230 240 250
EFLPGFERVE DASSFPLDYG IRRLDHAVGN VPELGPALTY VAGFTGFHQF
260 270 280 290 300
AEFTADDVGT AESGLNSAVL ASNDEMVLLP INEPVHGTKR KSQIQTYLEH
310 320 330 340 350
NEGAGLQHLA LMSEDIFRTL REMRKRSSIG GFDFMPSPPP TYYQNLKKRV
360 370 380 390 400
GDVLSDDQIK ECEELGILVD RDDQGTLLQI FTKPLGDRPT IFIEIIQRVG
410 420 430 440
CMMKDEEGKA YQSGGCGGFG KGNFSELFKS IEEYEKTLEA KQLVG
Length:445
Mass (Da):48,816
Last modified:January 1, 1998 - v2
Checksum:iFD0442F93556B3F5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4IDP2F4IDP2_ARATH
4-hydroxyphenylpyruvate dioxygenase
PDS1 HPD, HPPD, phytoene desaturation 1, At1g06570, F12K11.9
418Annotation score:

Sequence cautioni

The sequence AAF24813 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89267 mRNA Translation: AAB70025.1
AF000228 mRNA Translation: AAB58404.1
AF047834 mRNA Translation: AAC15697.1
AC007592 Genomic DNA Translation: AAF24813.1 Different initiation.
CP002684 Genomic DNA Translation: AEE28006.2
AF428446 mRNA Translation: AAL16215.1
AY072329 mRNA Translation: AAL61936.1
AY128745 mRNA Translation: AAM91145.1
PIRiB86201
T51585
RefSeqiNP_172144.3, NM_100536.4 [P93836-1]
UniGeneiAt.48158
At.71039

Genome annotation databases

EnsemblPlantsiAT1G06570.1; AT1G06570.1; AT1G06570 [P93836-1]
GeneIDi837168
GrameneiAT1G06570.1; AT1G06570.1; AT1G06570 [P93836-1]
KEGGiath:AT1G06570

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89267 mRNA Translation: AAB70025.1
AF000228 mRNA Translation: AAB58404.1
AF047834 mRNA Translation: AAC15697.1
AC007592 Genomic DNA Translation: AAF24813.1 Different initiation.
CP002684 Genomic DNA Translation: AEE28006.2
AF428446 mRNA Translation: AAL16215.1
AY072329 mRNA Translation: AAL61936.1
AY128745 mRNA Translation: AAM91145.1
PIRiB86201
T51585
RefSeqiNP_172144.3, NM_100536.4 [P93836-1]
UniGeneiAt.48158
At.71039

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SP9X-ray3.00A/B1-445[»]
1SQDX-ray1.80A23-445[»]
1TFZX-ray1.80A23-445[»]
1TG5X-ray1.90A23-445[»]
5CTOX-ray2.62A/B/C/D1-445[»]
5DHWX-ray2.62A/B1-445[»]
5XGKX-ray2.80A/B/C/D1-445[»]
ProteinModelPortaliP93836
SMRiP93836
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G06570.1

Chemistry databases

ChEMBLiCHEMBL2242740

PTM databases

iPTMnetiP93836

Proteomic databases

PaxDbiP93836
PRIDEiP93836

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G06570.1; AT1G06570.1; AT1G06570 [P93836-1]
GeneIDi837168
GrameneiAT1G06570.1; AT1G06570.1; AT1G06570 [P93836-1]
KEGGiath:AT1G06570

Organism-specific databases

AraportiAT1G06570

Phylogenomic databases

eggNOGiKOG0638 Eukaryota
COG3185 LUCA
InParanoidiP93836
KOiK00457
OMAiMVGNVGW
OrthoDBiEOG09360BAR
PhylomeDBiP93836

Enzyme and pathway databases

UniPathwayi
UPA00139;UER00362

UPA00975

BRENDAi1.13.11.27 399
ReactomeiR-ATH-71182 Phenylalanine and tyrosine catabolism
SABIO-RKiP93836

Miscellaneous databases

EvolutionaryTraceiP93836
PROiPR:P93836

Gene expression databases

ExpressionAtlasiP93836 baseline and differential
GenevisibleiP93836 AT

Family and domain databases

Gene3Di3.10.180.10, 2 hits
InterProiView protein in InterPro
IPR005956 4OHPhenylPyrv_dOase
IPR029068 Glyas_Bleomycin-R_OHBP_Dase
IPR004360 Glyas_Fos-R_dOase_dom
IPR037523 VOC
PANTHERiPTHR11959 PTHR11959, 1 hit
PfamiView protein in Pfam
PF00903 Glyoxalase, 1 hit
PIRSFiPIRSF009283 HPP_dOase, 1 hit
SUPFAMiSSF54593 SSF54593, 1 hit
TIGRFAMsiTIGR01263 4HPPD, 1 hit
PROSITEiView protein in PROSITE
PS51819 VOC, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHPPD_ARATH
AccessioniPrimary (citable) accession number: P93836
Secondary accession number(s): F4IDP1, O04330, Q9SHK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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