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Protein

Metallothionein-like protein 4A

Gene

MT4A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals (Probable). Functions as metal chelator of copper (Cu) and zinc (Zn) (PubMed:18287486). Plays a role in storing and distributing Zn ion in seed (PubMed:22014117).Curated2 Publications

Miscellaneous

Plants silencing both MT4A and MT4B have reduced seed weight and reduced seedling growth after germination.1 Publication

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-like protein 4A
Short name:
MT-4A
Alternative name(s):
EC protein homolog 1
Gene namesi
Name:MT4A
Ordered Locus Names:At2g42000
ORF Names:T6D20.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G42000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001974231 – 84Metallothionein-like protein 4AAdd BLAST84

Proteomic databases

PaxDbiP93746
PRIDEiP93746

Expressioni

Tissue specificityi

Expressed specifically in seeds.1 Publication

Developmental stagei

During embryo development, expressed from torpedo stage (6 days after pollination) to mature embryo.1 Publication

Inductioni

By abscisic acid (ABA) and jasmonic acid. Down-regulated by gibberellin.1 Publication

Gene expression databases

ExpressionAtlasiP93746 differential
GenevisibleiP93746 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G42000.2

Structurei

3D structure databases

ProteinModelPortaliP93746
SMRiP93746
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J62V Eukaryota
ENOG410Z4N5 LUCA
HOGENOMiHOG000243560
InParanoidiP93746
PhylomeDBiP93746

Family and domain databases

InterProiView protein in InterPro
IPR000316 Metallthion_15
PfamiView protein in Pfam
PF02068 Metallothio_PEC, 1 hit
PRINTSiPR00877 MTPLANTPEC

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: P93746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADTGKGSSV AGCNDSCGCP SPCPGGNSCR CRMREASAGD QGHMVCPCGE
60 70 80
HCGCNPCNCP KTQTQTSAKG CTCGEGCTCA SCAT
Length:84
Mass (Da):8,290
Last modified:November 1, 1997 - v2
Checksum:i09D76F26CDF87676
GO

Sequence cautioni

The sequence AAB63543 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68A → D in CAA83560 (PubMed:8580968).Curated1
Sequence conflicti83A → D in CAA83560 (PubMed:8580968).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90439 Genomic DNA Translation: AAB63543.1 Different initiation.
CP002685 Genomic DNA Translation: AEC10060.2
Z32602 mRNA Translation: CAA83560.1
PIRiG84848
RefSeqiNP_181731.2, NM_129764.2 [P93746-1]
UniGeneiAt.42759

Genome annotation databases

EnsemblPlantsiAT2G42000.1; AT2G42000.1; AT2G42000 [P93746-1]
AT2G42000.2; AT2G42000.2; AT2G42000
GeneIDi818800
GrameneiAT2G42000.1; AT2G42000.1; AT2G42000 [P93746-1]
AT2G42000.2; AT2G42000.2; AT2G42000
KEGGiath:AT2G42000

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMT4A_ARATH
AccessioniPrimary (citable) accession number: P93746
Secondary accession number(s): F4ILY8, Q42258
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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