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Entry version 97 (07 Oct 2020)
Sequence version 2 (01 Aug 1998)
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Protein

Endochitinase

Gene

chi1

Organism
Persea americana (Avocado)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Defense against chitin-containing fungal pathogens. Has in vitro antifungal activity against F.oxysporum inhibiting its growth and the branching of its hyphae. Has endochitinase activity, but no exochitinase or lysozyme activities.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei140Proton donorUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntimicrobial, Glycosidase, Hydrolase, Pathogenesis-related protein
Biological processCarbohydrate metabolism, Chitin degradation, Plant defense, Polysaccharide degradation
LigandChitin-binding

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM18, Carbohydrate-Binding Module Family 18
GH19, Glycoside Hydrolase Family 19

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endochitinase2 PublicationsImported (EC:3.2.1.142 PublicationsImported)
Alternative name(s):
Allergen Pers a 13 Publications
Allergen Prs a 15 Publications
Chitin-binding avocado protein1 Publication
Short name:
CBAP1 Publication
Class I chitinase4 Publications
PaI11 Publication
Allergen: Pers a 1.0101Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chi1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPersea americana (Avocado)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3435 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaMagnoliidaeLauralesLauraceaePersea

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section is used for proteins that cause an allergic reaction in mammals. We usually specify in which species the protein is allergenic.<p><a href='/help/allergenic_properties' target='_top'>More...</a></p>Allergenic propertiesi

Causes an allergic reaction in human (PubMed:9774427, PubMed:9679856, PubMed:10231327, PubMed:14610495, PubMed:10482846, PubMed:10887324, PubMed:16433216, PubMed:18205857, PubMed:21284746). Involved (at least via the N-terminal chitin-binding hevein-like domain) in cross-reactions with natural rubber latex (latex-fruit allergy syndrome) (PubMed:9774427, PubMed:9679856, PubMed:10231327, PubMed:14610495, PubMed:10482846, PubMed:10887324, PubMed:16433216). Binds to IgE of patients allergic to avocado, chestnut and/or banana (PubMed:9679856, PubMed:10482846, PubMed:16433216, PubMed:21284746). Binds to IgE in 75% of the 20 patients tested allergic to latex (PubMed:9774427). Binds to IgE in 80% of the 15 patients tested allergic to avocado and latex (PubMed:10231327). Binds to IgE in 53% of the 92 and 38% of the 26 kiwifruit-allergic patients tested by ELISA and IgE immunodetection assays, respectively. Only 12% of the 25 kiwifruit-allergic patients tested are found positive by skin prick test (PubMed:18205857). Binds to IgE in 29% of the 51 pediatric patients tested allergic to banana (PubMed:21284746). IgE-binding is not abolished by digestion with artificial gastric juice or simulated gastric fluid (PubMed:10231327, PubMed:14610495). In vitro IgE-binding and in vivo allergenicity (skin prick test) is abolished by heating (PubMed:10887324). Induces degranulation of human basohphils and histamine release (PubMed:16433216).9 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
3414, Pers a 1.0101
546, Pers a 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysis4 PublicationsAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500416189626 – 326EndochitinaseSequence analysis4 PublicationsAdd BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 43UniRule annotation
Disulfide bondi37 ↔ 49UniRule annotation
Disulfide bondi42 ↔ 56UniRule annotation
Disulfide bondi60 ↔ 64UniRule annotation
Disulfide bondi96 ↔ 158UniRule annotation
Disulfide bondi170 ↔ 178UniRule annotation
Disulfide bondi277 ↔ 309UniRule annotation

Keywords - PTMi

Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the pulp of the fruit (at protein level) (PubMed:9679856, PubMed:14610495, PubMed:23019098). Expressed in mesocarp (at protein level) (PubMed:9774427).4 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P93680

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 66Chitin-binding type-1PROSITE-ProRule annotationCuratedAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.60.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001002, Chitin-bd_1
IPR018371, Chitin-binding_1_CS
IPR036861, Endochitinase-like_sf
IPR016283, Glyco_hydro_19
IPR000726, Glyco_hydro_19_cat
IPR023346, Lysozyme-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00187, Chitin_bind_1, 1 hit
PF00182, Glyco_hydro_19, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001060, Endochitinase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00451, CHITINBINDNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00270, ChtBD1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53955, SSF53955, 1 hit
SSF57016, SSF57016, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00026, CHIT_BIND_I_1, 1 hit
PS50941, CHIT_BIND_I_2, 1 hit
PS00773, CHITINASE_19_1, 1 hit
PS00774, CHITINASE_19_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P93680-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYCTASLPL LLLLLVGLLA GEAFAEQCGR QAGGALCPGG LCCSQFGWCG
60 70 80 90 100
STSDYCGPTC QSQCGGVTPS PGGGVASLIS QSVFNQMLKH RNDAACQAKG
110 120 130 140 150
FYTYNAFIAA ANSFNGFASV GDTATRKREI AAFLAQTSHE TTGGWATAPD
160 170 180 190 200
GPYAWGYCFL KEQGNPPDYC VPTAQWPCAP GKKYYGRGPI QISYNYNYGP
210 220 230 240 250
AGRAIGYDLI NNPDAVATDP VISFKTALWF WMTPQSPKPS CHNVITGRWT
260 270 280 290 300
PSAADRAAGR LPGYGVITNI INGGIECGKG FNDKVADRIG FYKRYCDLLG
310 320
VSYGSNLDCY NQRSFGVSTN PLAASS
Length:326
Mass (Da):34,586
Last modified:August 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i643B20589E062E61
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti203R → A AA sequence (PubMed:9774427).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z78202 mRNA Translation: CAB01591.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z78202 mRNA Translation: CAB01591.1

3D structure databases

SMRiP93680
ModBaseiSearch...

Protein family/group databases

Allergomei3414, Pers a 1.0101
546, Pers a 1
CAZyiCBM18, Carbohydrate-Binding Module Family 18
GH19, Glycoside Hydrolase Family 19

Family and domain databases

Gene3Di3.30.60.10, 1 hit
InterProiView protein in InterPro
IPR001002, Chitin-bd_1
IPR018371, Chitin-binding_1_CS
IPR036861, Endochitinase-like_sf
IPR016283, Glyco_hydro_19
IPR000726, Glyco_hydro_19_cat
IPR023346, Lysozyme-like_dom_sf
PfamiView protein in Pfam
PF00187, Chitin_bind_1, 1 hit
PF00182, Glyco_hydro_19, 1 hit
PIRSFiPIRSF001060, Endochitinase, 1 hit
PRINTSiPR00451, CHITINBINDNG
SMARTiView protein in SMART
SM00270, ChtBD1, 1 hit
SUPFAMiSSF53955, SSF53955, 1 hit
SSF57016, SSF57016, 1 hit
PROSITEiView protein in PROSITE
PS00026, CHIT_BIND_I_1, 1 hit
PS50941, CHIT_BIND_I_2, 1 hit
PS00773, CHITINASE_19_1, 1 hit
PS00774, CHITINASE_19_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHIT_PERAE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P93680
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 12, 2020
Last sequence update: August 1, 1998
Last modified: October 7, 2020
This is version 97 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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