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Protein

(+)-delta-cadinene synthase

Gene

CDN1

Organism
Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.

Catalytic activityi

(2E,6E)-farnesyl diphosphate = (+)-delta-cadinene + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Pathwayi: terpenoid biosynthesis

This protein is involved in the pathway terpenoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway terpenoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi307Magnesium 1By similarity1
Metal bindingi307Magnesium 2By similarity1
Metal bindingi311Magnesium 1By similarity1
Metal bindingi311Magnesium 2By similarity1
Metal bindingi451Magnesium 3By similarity1
Metal bindingi455Magnesium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00213

Names & Taxonomyi

Protein namesi
Recommended name:
(+)-delta-cadinene synthase (EC:4.2.3.13)
Short name:
D-cadinene synthase
Gene namesi
Name:CDN1
OrganismiGossypium hirsutum (Upland cotton) (Gossypium mexicanum)
Taxonomic identifieri3635 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMalvalesMalvaceaeMalvoideaeGossypium
Proteomesi
  • UP000189702 Componenti: Genome assembly

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001864431 – 554(+)-delta-cadinene synthaseAdd BLAST554

Proteomic databases

PRIDEiP93665

Expressioni

Inductioni

By bacterial infection.

Structurei

3D structure databases

ProteinModelPortaliP93665
SMRiP93665
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 311DDXXD motif5

Domaini

The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg2+.

Sequence similaritiesi

Belongs to the terpene synthase family.Curated

Phylogenomic databases

KOiK14183

Family and domain databases

Gene3Di1.10.600.10, 1 hit
1.50.10.130, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR034741 Terpene_cyclase_like_1_C
IPR001906 Terpene_synth_N
IPR036965 Terpene_synth_N_sf
IPR005630 Terpene_synthase_metal-bd
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF01397 Terpene_synth, 1 hit
PF03936 Terpene_synth_C, 1 hit
SFLDiSFLDG01019 Terpene_Cyclase_Like_1_C_Termi, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF48576 SSF48576, 1 hit

Sequencei

Sequence statusi: Complete.

P93665-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASQVSQMPS SSPLSSNKDE MRPKADFQPS IWGDFFLNCP DKNIDAETQK
60 70 80 90 100
RHQQLKEEVR KMIVAPMANS TLKLAFIDSV QGLGVSYHFT KEIEDELENI
110 120 130 140 150
YHNNNDAEND LYTTSLRFRL LREHGFHVSC DVFNKFKDEQ GNFKSSVTSD
160 170 180 190 200
VRGLLELYQA SYLRVHGEDI LDEAISFTSN HLSLAVASLD HPLSEEVSHA
210 220 230 240 250
LKQSIRRGLP RVEARHYLSV YQDIESHNKV LLEFAKIDFN MVQLLHRKEL
260 270 280 290 300
SEISRWWKDL DFQRKLPYAR DRVVEGYFWI SGVYFEPQYS LGRKMLTKVI
310 320 330 340 350
AMASIVDDTY DSYATYEELI PYTNAIERWD IKCIDELPEY MKPSYKALLD
360 370 380 390 400
VYEEMEQLVA EHGRQYRVEY AKNAMIRLAQ SYLVEARWTL QNYKPSFEEF
410 420 430 440 450
KANALPTCGY AMLAITSFVG MGDIVTPETF KWAANDPKII QASTIICRFM
460 470 480 490 500
DDVTEHKFKH RREDDCSAIE CYMEEYGVTA QEAYDVFNKH VESAWKDVNQ
510 520 530 540 550
GFLKPTEMPT EVLNRSLNLA RVMDVLYREG DGYTYVGKAA KGGITSLLIE

PIAL
Length:554
Mass (Da):64,020
Last modified:May 1, 1997 - v1
Checksum:i8BCC78AD8CA5B816
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88318 mRNA Translation: AAC12784.1
RefSeqiNP_001313854.1, NM_001326925.1
UniGeneiGhi.16945

Genome annotation databases

GeneIDi107903500
KEGGiag:AAC12784

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Delta-cadinene synthase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88318 mRNA Translation: AAC12784.1
RefSeqiNP_001313854.1, NM_001326925.1
UniGeneiGhi.16945

3D structure databases

ProteinModelPortaliP93665
SMRiP93665
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP93665

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107903500
KEGGiag:AAC12784

Phylogenomic databases

KOiK14183

Enzyme and pathway databases

UniPathwayi
UPA00213

Family and domain databases

Gene3Di1.10.600.10, 1 hit
1.50.10.130, 1 hit
InterProiView protein in InterPro
IPR008949 Isoprenoid_synthase_dom_sf
IPR034741 Terpene_cyclase_like_1_C
IPR001906 Terpene_synth_N
IPR036965 Terpene_synth_N_sf
IPR005630 Terpene_synthase_metal-bd
IPR008930 Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF01397 Terpene_synth, 1 hit
PF03936 Terpene_synth_C, 1 hit
SFLDiSFLDG01019 Terpene_Cyclase_Like_1_C_Termi, 1 hit
SUPFAMiSSF48239 SSF48239, 1 hit
SSF48576 SSF48576, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCS1_GOSHI
AccessioniPrimary (citable) accession number: P93665
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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