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Protein

Alcohol dehydrogenase class-3

Gene

FDH

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.By similarity
A secondary alcohol + NAD+ = a ketone + NADH.By similarity
S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi49Zinc 1; catalyticBy similarity1
Binding sitei50NADBy similarity1
Binding sitei51SubstrateBy similarity1
Metal bindingi71Zinc 1; catalyticBy similarity1
Binding sitei71SubstrateBy similarity1
Metal bindingi72Zinc 1By similarity1
Metal bindingi101Zinc 2By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi115Zinc 2By similarity1
Metal bindingi179Zinc 1; catalyticBy similarity1
Binding sitei228NADBy similarity1
Binding sitei233NADBy similarity1
Binding sitei274NAD; via carbonyl oxygenBy similarity1
Binding sitei374NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 209NADBy similarity6
Nucleotide bindingi297 – 299NADBy similarity3
Nucleotide bindingi322 – 324NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase class-3 (EC:1.1.1.1By similarity)
Alternative name(s):
Alcohol dehydrogenase class-III
Glutathione-dependent formaldehyde dehydrogenase (EC:1.1.1.-)
Short name:
FALDH
Short name:
FDH
Short name:
GSH-FDH
S-(hydroxymethyl)glutathione dehydrogenase (EC:1.1.1.284By similarity)
Gene namesi
Name:FDH
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607721 – 381Alcohol dehydrogenase class-3Add BLAST381

Proteomic databases

PaxDbiP93629
PRIDEiP93629

Expressioni

Tissue specificityi

Expressed at low levels in the leaves.1 Publication

Gene expression databases

ExpressionAtlasiP93629 differential

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4577.GRMZM5G824600_P03

Structurei

3D structure databases

ProteinModelPortaliP93629
SMRiP93629
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
KOiK00121

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P93629-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPTQGQVI TCKAAVAYEP NKPLVIEDVQ VAPPQAGEVR VKILFTALCH
60 70 80 90 100
TDHYTWSGKD PEGLFPCILG HEAAGIVESV GEGVTDVQPG DHVIPCYQAE
110 120 130 140 150
CKECKFCKSG KTNLCGKVRS ATGVGVMMND MKSRFSVNGK PIYHFMGTST
160 170 180 190 200
FSQYTVVHDV SVAKINPQAP LDKVCLLGCG VPTGLGAVWN TAKVESGSVV
210 220 230 240 250
AVFGLGTVGL AVAEGAKAAG ASRVIGIDID NKKFDVAKNF GVTEFVNPKE
260 270 280 290 300
HDKPIQQVLV DLTDGGVDYS FECIGNVSIM RAALECSDKG WGTSVIVGVA
310 320 330 340 350
ASGQEISTRP FQLVTGRVWK GTAFGGFKSR TQVPWLVDKY MKKEIKVDEY
360 370 380
ITHNMNLADI NDAFHLLHEG GCLRCVLAMQ I
Length:381
Mass (Da):40,772
Last modified:May 1, 1997 - v1
Checksum:iEABC4BEEDF76B65A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11029 mRNA Translation: CAA71913.1
PIRiT03289
RefSeqiNP_001105485.1, NM_001112015.1
UniGeneiZm.2742

Genome annotation databases

GeneIDi542459
KEGGizma:542459

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11029 mRNA Translation: CAA71913.1
PIRiT03289
RefSeqiNP_001105485.1, NM_001112015.1
UniGeneiZm.2742

3D structure databases

ProteinModelPortaliP93629
SMRiP93629
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM5G824600_P03

Proteomic databases

PaxDbiP93629
PRIDEiP93629

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi542459
KEGGizma:542459

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
KOiK00121

Gene expression databases

ExpressionAtlasiP93629 differential

Family and domain databases

CDDicd08300 alcohol_DH_class_III, 1 hit
InterProiView protein in InterPro
IPR014183 ADH_3
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR02818 adh_III_F_hyde, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADHX_MAIZE
AccessioniPrimary (citable) accession number: P93629
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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