Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 154 (02 Dec 2020)
Sequence version 2 (15 Dec 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Fumarate hydratase 1, mitochondrial

Gene

FUM1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:29688630). Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH (By similarity).By similarity1 Publication

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Fumarate hydratase activity (fumarate to L-malate) is strongly inhibited by phosphoenolpyruvate, citrate, oxaloacetate, ATP and ADP (PubMed:29688630). Malate dehydratase activity (malate to fumarate) is activated by oxaloacetate, pyruvate, Asn and Gln (PubMed:29688630). Malate dehydratase activity (malate to fumarate) is inhibited by citrate, succinate, ADP, ATP, glucose-6P and phosphoenolpyruvate (PubMed:29688630).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kcat is 21 sec(-1) for fumarate (at pH 8.0) (PubMed:29688630). Kcat is 15.3 sec(-1) for (S)-malate (at pH 8.0) (PubMed:29688630).1 Publication
  1. KM=0.7 mM for fumarate (at pH 8.0)1 Publication
  2. KM=1.8 mM for (S)-malate (at pH 8.0)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

    This protein is involved in step 1 of the subpathway that synthesizes (S)-malate from fumarate.By similarity
    Proteins known to be involved in this subpathway in this organism are:
    1. Fumarate hydratase 1, mitochondrial (FUM1)
    This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from fumarate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei215SubstrateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei216Proton donor/acceptorBy similarity1
    Active sitei346By similarity1
    Binding sitei347SubstrateBy similarity1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei359Important for catalytic activityBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionLyase
    Biological processTricarboxylic acid cycle

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    4.2.1.2, 399

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00223;UER01007

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Fumarate hydratase 1, mitochondrial1 Publication (EC:4.2.1.21 Publication)
    Short name:
    AtFUM11 Publication
    Short name:
    Fumarase 11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:FUM11 Publication
    Ordered Locus Names:At2g47510
    ORF Names:T30B22.19
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT2G47510

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2061966, AT2G47510

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Embryonic lethality.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 28Mitochondrion1 PublicationAdd BLAST28
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001032929 – 492Fumarate hydratase 1, mitochondrialAdd BLAST464

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P93033

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P93033

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    230004

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P93033

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    P93033

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P93033

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P93033, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P93033, AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer.

    1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    4699, 5 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P93033, 2 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT2G47510.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    P93033

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni127 – 129Substrate bindingBy similarity3
    Regioni157 – 160Substrate binding (B site)By similarity4
    Regioni167 – 169Substrate bindingBy similarity3
    Regioni352 – 354Substrate bindingBy similarity3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1317, Eukaryota

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_021594_4_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P93033

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    HDSMGEV

    Database of Orthologous Groups

    More...
    OrthoDBi
    1022919at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P93033

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01362, Fumarase_classII, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.275.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00743, FumaraseC, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR005677, Fum_hydII
    IPR024083, Fumarase/histidase_N
    IPR018951, Fumarase_C_C
    IPR020557, Fumarate_lyase_CS
    IPR000362, Fumarate_lyase_fam
    IPR022761, Fumarate_lyase_N
    IPR008948, L-Aspartase-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11444, PTHR11444, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF10415, FumaraseC_C, 1 hit
    PF00206, Lyase_1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00149, FUMRATELYASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF48557, SSF48557, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00979, fumC_II, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00163, FUMARATE_LYASES, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    P93033-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSIYVASRRL SGGTTVTALR YATSLRSYST SFREERDTFG PIQVPSDKLW
    60 70 80 90 100
    GAQTQRSLQN FEIGGERERM PEPIVRAFGV LKKCAAKVNM EYGLDPTIGK
    110 120 130 140 150
    AIMQAAQEVA EGKLNDHFPL VVWQTGSGTQ SNMNANEVIA NRAAEILGRK
    160 170 180 190 200
    RGEKCVHPND HVNRSQSSND TFPTVMHIAA ATEINSRLIP SLKTLHSTLE
    210 220 230 240 250
    SKSFEFKDIV KIGRTHTQDA TPLTLGQEFG GYATQVKYGL NRVTCTLPRL
    260 270 280 290 300
    YQLAQGGTAV GTGLNTKKGF DVKIAAAVAE ETNLPFVTAE NKFEALAAHD
    310 320 330 340 350
    ACVETSGSLN TIATSLMKIA NDIRFLGSGP RCGLGELVLP ENEPGSSIMP
    360 370 380 390 400
    GKVNPTQCEA LTMVCAQVMG NHVAVTVGGS NGHFELNVFK PVIASALLHS
    410 420 430 440 450
    VRLIADASAS FEKNCVRGIE ANRERISKLL HESLMLVTSL NPKIGYDNAA
    460 470 480 490
    AVAKKAHKEG CTLKEAALNL GVLTAEEFDT LVVPEKMIGP SD
    Length:492
    Mass (Da):53,000
    Last modified:December 15, 2003 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF07D2D393966B3E
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8 – 9RR → A in AAB39989 (Ref. 1) Curated2
    Sequence conflicti197S → R in AAB39989 (Ref. 1) Curated1
    Sequence conflicti393 – 394IA → TS in AAB39989 (Ref. 1) Curated2
    Sequence conflicti442P → R in AAB39989 (Ref. 1) Curated1
    Sequence conflicti446Y → C in AAB39989 (Ref. 1) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U82202 mRNA Translation: AAB39989.1
    AC002535 Genomic DNA Translation: AAC62859.1
    CP002685 Genomic DNA Translation: AEC10852.1
    CP002685 Genomic DNA Translation: AEC10853.1
    CP002685 Genomic DNA Translation: ANM62150.1
    AF020303 Genomic DNA Translation: AAB71399.1
    AY054252 mRNA Translation: AAL06911.1
    AY062460 mRNA Translation: AAL32538.1
    BT003361 mRNA Translation: AAO29979.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    T00433

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001078075.1, NM_001084606.2
    NP_001324328.1, NM_001337266.1
    NP_182273.1, NM_130319.4

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT2G47510.1; AT2G47510.1; AT2G47510
    AT2G47510.2; AT2G47510.2; AT2G47510
    AT2G47510.3; AT2G47510.3; AT2G47510

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    819364

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT2G47510.1; AT2G47510.1; AT2G47510
    AT2G47510.2; AT2G47510.2; AT2G47510
    AT2G47510.3; AT2G47510.3; AT2G47510

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT2G47510

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U82202 mRNA Translation: AAB39989.1
    AC002535 Genomic DNA Translation: AAC62859.1
    CP002685 Genomic DNA Translation: AEC10852.1
    CP002685 Genomic DNA Translation: AEC10853.1
    CP002685 Genomic DNA Translation: ANM62150.1
    AF020303 Genomic DNA Translation: AAB71399.1
    AY054252 mRNA Translation: AAL06911.1
    AY062460 mRNA Translation: AAL32538.1
    BT003361 mRNA Translation: AAO29979.1
    PIRiT00433
    RefSeqiNP_001078075.1, NM_001084606.2
    NP_001324328.1, NM_001337266.1
    NP_182273.1, NM_130319.4

    3D structure databases

    SMRiP93033
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi4699, 5 interactors
    IntActiP93033, 2 interactors
    STRINGi3702.AT2G47510.1

    PTM databases

    iPTMnetiP93033
    MetOSiteiP93033
    SwissPalmiP93033

    Proteomic databases

    PaxDbiP93033
    PRIDEiP93033
    ProteomicsDBi230004

    Genome annotation databases

    EnsemblPlantsiAT2G47510.1; AT2G47510.1; AT2G47510
    AT2G47510.2; AT2G47510.2; AT2G47510
    AT2G47510.3; AT2G47510.3; AT2G47510
    GeneIDi819364
    GrameneiAT2G47510.1; AT2G47510.1; AT2G47510
    AT2G47510.2; AT2G47510.2; AT2G47510
    AT2G47510.3; AT2G47510.3; AT2G47510
    KEGGiath:AT2G47510

    Organism-specific databases

    AraportiAT2G47510
    TAIRilocus:2061966, AT2G47510

    Phylogenomic databases

    eggNOGiKOG1317, Eukaryota
    HOGENOMiCLU_021594_4_1_1
    InParanoidiP93033
    OMAiHDSMGEV
    OrthoDBi1022919at2759
    PhylomeDBiP93033

    Enzyme and pathway databases

    UniPathwayiUPA00223;UER01007
    BRENDAi4.2.1.2, 399

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:P93033

    Gene expression databases

    ExpressionAtlasiP93033, baseline and differential
    GenevisibleiP93033, AT

    Family and domain databases

    CDDicd01362, Fumarase_classII, 1 hit
    Gene3Di1.10.275.10, 1 hit
    HAMAPiMF_00743, FumaraseC, 1 hit
    InterProiView protein in InterPro
    IPR005677, Fum_hydII
    IPR024083, Fumarase/histidase_N
    IPR018951, Fumarase_C_C
    IPR020557, Fumarate_lyase_CS
    IPR000362, Fumarate_lyase_fam
    IPR022761, Fumarate_lyase_N
    IPR008948, L-Aspartase-like
    PANTHERiPTHR11444, PTHR11444, 1 hit
    PfamiView protein in Pfam
    PF10415, FumaraseC_C, 1 hit
    PF00206, Lyase_1, 1 hit
    PRINTSiPR00149, FUMRATELYASE
    SUPFAMiSSF48557, SSF48557, 1 hit
    TIGRFAMsiTIGR00979, fumC_II, 1 hit
    PROSITEiView protein in PROSITE
    PS00163, FUMARATE_LYASES, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUM1_ARATH
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P93033
    Secondary accession number(s): O24649
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: December 2, 2020
    This is version 154 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again