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UniProtKB - P93025 (PHOT2_ARATH)

Entry version 175 (07 Oct 2020)
Sequence version 2 (22 Nov 2005)
Previous versions | rss
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Protein

Phototropin-2

Gene

PHOT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein kinase that acts as a blue light photoreceptor in a signal-transduction pathway for photo-induced movements. Phosphorylates BLUS1, a kinase involved in stomatal opening. Mediates calcium spiking of extra- and intracellular origins in response to blue light. Involved in hypocotyl phototropism. Contributes to the chloroplast accumulation in low blue light and mediates their translocation (avoidance response) at high fluence. Regulates stomata opening and photomorphogenesis response of leaf tissue. Not involved in hypocotyl elongation inhibition, anthocyanin accumulation or cotyledon opening.6 Publications

Miscellaneous

Undergoes a photocycle characterized by fluorescence and absorption changes induced by blue light. Half-time of photoproduct formation is 11 seconds and 15 seconds for dark regeneration.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FMNCuratedNote: Binds 2 FMN per subunit.Curated

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Absorptioni

Abs(max)=450 nm1 PublicationExhibits a smaller absorbance peak at 350 nm. The broad fluorescence emission spectrum peaks at 490 nm.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei187FMN1 Publication1
Binding sitei202FMN1 Publication1
Binding sitei212FMN1 Publication1
Binding sitei233FMN1 Publication1
Binding sitei443FMNBy similarity1
Binding sitei458FMNBy similarity1
Binding sitei468FMNBy similarity1
Binding sitei489FMNBy similarity1
Binding sitei606ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei702Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi169 – 174FMN1 Publication6
Nucleotide bindingi425 – 430FMNBy similarity6
Nucleotide bindingi583 – 591ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Photoreceptor protein, Receptor, Serine/threonine-protein kinase, Transferase
Biological processSensory transduction
LigandATP-binding, Chromophore, Flavoprotein, FMN, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phototropin-2 (EC:2.7.11.1)
Alternative name(s):
Defective in chloroplast avoidance protein 1
Non-phototropic hypocotyl 1-like protein 1
Short name:
AtKin7
Short name:
NPH1-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHOT2
Synonyms:CAV1, KIN7, NPL1
Ordered Locus Names:At5g58140
ORF Names:K21L19.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT5G58140

The Arabidopsis Information Resource

More...TAIRi		locus:2155821, AT5G58140

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi170C → A: No effect on light-dependent autophosphorylation. 1 Publication1
Mutagenesisi217T → Q: Loss of dimerization. 1 Publication1
Mutagenesisi232M → V: Loss of dimerization. 1 Publication1
Mutagenesisi426C → A: Severe loss of light-sensing and light-dependent autophosphorylation. 1 Publication1
Mutagenesisi727T → I in cav1-2; loss of chloroplast avoidance response in response to high fluence blue light. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000865231 – 915Phototropin-2Add BLAST915

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei121PhosphoserineBy similarity1
Modified residuei170S-4a-FMN cysteineBy similarity1
Modified residuei364PhosphoserineCombined sources1
Modified residuei426S-4a-FMN cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated in response to blue light irradiation.1 Publication
2 molecules of FMN bind covalently to cysteines after exposure to blue light and are reversed in the dark.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P93025

PRoteomics IDEntifications database

More...PRIDEi		P93025

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		235062 [P93025-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P93025

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in leaves, stems and flowers, and to a lower extent in roots.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Light fluence rate-dependent induction, independent of light quality.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P93025, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P93025, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with PKS1, PKS2, RPT3 and PHOT1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		21170, 11 interactors

Database of interacting proteins

More...DIPi		DIP-53468N

Protein interaction database and analysis system

More...IntActi		P93025, 4 interactors

Molecular INTeraction database

More...MINTi		P93025

STRING: functional protein association networks

More...STRINGi		3702.AT5G58140.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1915
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P93025

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P93025

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini120 – 193PAS 1PROSITE-ProRule annotationAdd BLAST74
Domaini194 – 248PAC 1PROSITE-ProRule annotationAdd BLAST55
Domaini376 – 449PAS 2PROSITE-ProRule annotationAdd BLAST74
Domaini450 – 504PAC 2PROSITE-ProRule annotationAdd BLAST55
Domaini577 – 864Protein kinasePROSITE-ProRule annotationAdd BLAST288

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni720 – 774Activation loopBy similarityAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi16 – 114Ser-richAdd BLAST99

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The activation loop within the kinase domain is the target of phosphorylation (By similarity). The PAS (PER-ARNT-SIM) domains are required for the binding of FMN chromophores.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPPH, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006321_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P93025

KEGG Orthology (KO)

More...KOi		K20715

Database for complete collections of gene phylogenies

More...PhylomeDBi		P93025

Family and domain databases

Conserved Domains Database

More...CDDi		cd00130, PAS, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR001610, PAC
IPR000014, PAS
IPR000700, PAS-assoc_C
IPR035965, PAS-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13426, PAS_9, 2 hits
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00086, PAC, 2 hits
SM00091, PAS, 2 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55785, SSF55785, 2 hits
SSF56112, SSF56112, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00229, sensory_box, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50113, PAC, 2 hits
PS50112, PAS, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P93025-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERPRAPPSP LNDAESLSER RSLEIFNPSS GKETHGSTSS SSKPPLDGNN 
        60         70         80         90        100
KGSSSKWMEF QDSAKITERT AEWGLSAVKP DSGDDGISFK LSSEVERSKN 
       110        120        130        140        150
MSRRSSEEST SSESGAFPRV SQELKTALST LQQTFVVSDA TQPHCPIVYA 
       160        170        180        190        200
SSGFFTMTGY SSKEIVGRNC RFLQGPDTDK NEVAKIRDCV KNGKSYCGRL 
       210        220        230        240        250
LNYKKDGTPF WNLLTVTPIK DDQGNTIKFI GMQVEVSKYT EGVNDKALRP 
       260        270        280        290        300
NGLSKSLIRY DARQKEKALD SITEVVQTIR HRKSQVQESV SNDTMVKPDS 
       310        320        330        340        350
STTPTPGRQT RQSDEASKSF RTPGRVSTPT GSKLKSSNNR HEDLLRMEPE 
       360        370        380        390        400
ELMLSTEVIG QRDSWDLSDR ERDIRQGIDL ATTLERIEKN FVISDPRLPD 
       410        420        430        440        450
NPIIFASDSF LELTEYSREE ILGRNCRFLQ GPETDQATVQ KIRDAIRDQR 
       460        470        480        490        500
EITVQLINYT KSGKKFWNLF HLQPMRDQKG ELQYFIGVQL DGSDHVEPLQ 
       510        520        530        540        550
NRLSERTEMQ SSKLVKATAT NVDEAVRELP DANTRPEDLW AAHSKPVYPL 
       560        570        580        590        600
PHNKESTSWK AIKKIQASGE TVGLHHFKPI KPLGSGDTGS VHLVELKGTG 
       610        620        630        640        650
ELYAMKAMEK TMMLNRNKAH RACIEREIIS LLDHPFLPTL YASFQTSTHV 
       660        670        680        690        700
CLITDFCPGG ELFALLDRQP MKILTEDSAR FYAAEVVIGL EYLHCLGIVY 
       710        720        730        740        750
RDLKPENILL KKDGHIVLAD FDLSFMTTCT PQLIIPAAPS KRRRSKSQPL 
       760        770        780        790        800
PTFVAEPSTQ SNSFVGTEEY IAPEIITGAG HTSAIDWWAL GILLYEMLYG 
       810        820        830        840        850
RTPFRGKNRQ KTFANILHKD LTFPSSIPVS LVGRQLINTL LNRDPSSRLG 
       860        870        880        890        900
SKGGANEIKQ HAFFRGINWP LIRGMSPPPL DAPLSIIEKD PNAKDIKWED 
       910 
DGVLVNSTDL DIDLF
Length:915
Mass (Da):102,472
Last modified:November 22, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA163E2596289737
GO
Isoform 2 (identifier: P93025-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-549: RPEDLWAAHSKPVYP → VRCTSSLLLNKDGKV
     550-915: Missing.

Note: May be due to a competing acceptor splice site.Curated
Show »
Length:549
Mass (Da):61,600
Checksum:i3777BA44BAE08C96
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MS49A8MS49_ARATH
Phototropin 2
PHOT2 AtPHOT2, NPL1, phototropin 2, At5g58140, K21L19.6
898Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F4KDJ3F4KDJ3_ARATH
Phototropin 2
PHOT2 AtPHOT2, NPL1, phototropin 2, At5g58140, K21L19.6
689Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti722D → Y in AAB39188 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016306535 – 549RPEDL…KPVYP → VRCTSSLLLNKDGKV in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_016307550 – 915Missing in isoform 2. 1 PublicationAdd BLAST366

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF053941 mRNA Translation: AAC27293.2
AB019228, AB024029 Genomic DNA Translation: BAB09904.1
CP002688 Genomic DNA Translation: AED97002.1
CP002688 Genomic DNA Translation: AED97004.1
CP002688 Genomic DNA Translation: ANM68619.1
CP002688 Genomic DNA Translation: ANM68620.1
CP002688 Genomic DNA Translation: ANM68621.1
AY093141 mRNA Translation: AAM13140.1
BT008901 mRNA Translation: AAP68340.1
U79744 mRNA Translation: AAB39188.1

Protein sequence database of the Protein Information Resource

More...PIRi		T51600

NCBI Reference Sequences

More...RefSeqi		NP_001318824.1, NM_001345288.1 [P93025-1]
NP_001330355.1, NM_001345289.1 [P93025-1]
NP_001330356.1, NM_001345290.1 [P93025-1]
NP_851210.1, NM_180879.2 [P93025-1]
NP_851211.1, NM_180880.2 [P93025-1]

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT5G58140.1; AT5G58140.1; AT5G58140 [P93025-1]
AT5G58140.2; AT5G58140.2; AT5G58140 [P93025-1]
AT5G58140.5; AT5G58140.5; AT5G58140 [P93025-1]
AT5G58140.6; AT5G58140.6; AT5G58140 [P93025-1]
AT5G58140.7; AT5G58140.7; AT5G58140 [P93025-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		835926

Gramene; a comparative resource for plants

More...Gramenei		AT5G58140.1; AT5G58140.1; AT5G58140 [P93025-1]
AT5G58140.2; AT5G58140.2; AT5G58140 [P93025-1]
AT5G58140.5; AT5G58140.5; AT5G58140 [P93025-1]
AT5G58140.6; AT5G58140.6; AT5G58140 [P93025-1]
AT5G58140.7; AT5G58140.7; AT5G58140 [P93025-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT5G58140

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053941 mRNA Translation: AAC27293.2
AB019228, AB024029 Genomic DNA Translation: BAB09904.1
CP002688 Genomic DNA Translation: AED97002.1
CP002688 Genomic DNA Translation: AED97004.1
CP002688 Genomic DNA Translation: ANM68619.1
CP002688 Genomic DNA Translation: ANM68620.1
CP002688 Genomic DNA Translation: ANM68621.1
AY093141 mRNA Translation: AAM13140.1
BT008901 mRNA Translation: AAP68340.1
U79744 mRNA Translation: AAB39188.1
PIRiT51600
RefSeqiNP_001318824.1, NM_001345288.1 [P93025-1]
NP_001330355.1, NM_001345289.1 [P93025-1]
NP_001330356.1, NM_001345290.1 [P93025-1]
NP_851210.1, NM_180879.2 [P93025-1]
NP_851211.1, NM_180880.2 [P93025-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z6DX-ray2.00A/B117-246[»]
4EEPX-ray1.70A385-496[»]
4EERX-ray1.75A385-496[»]
4EESX-ray1.80A385-496[»]
4EETX-ray1.20B/D385-496[»]
4EEUX-ray1.41A385-496[»]
4NXBX-ray2.56A/B388-496[»]
4NXEX-ray2.10A/B388-496[»]
4NXFX-ray1.77A/B388-496[»]
4NXGX-ray2.09A/B388-496[»]
6GPUX-ray1.17A387-492[»]
6GPVX-ray2.00A387-492[»]
6QQHX-ray1.38A387-507[»]
6QQIX-ray1.70A387-507[»]
6QQJX-ray2.08A387-507[»]
6QQKX-ray2.40A387-507[»]
6QSAX-ray1.70A387-507[»]
6S45X-ray2.20A387-492[»]
6S46X-ray2.75A387-492[»]
SMRiP93025
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi21170, 11 interactors
DIPiDIP-53468N
IntActiP93025, 4 interactors
MINTiP93025
STRINGi3702.AT5G58140.2

PTM databases

iPTMnetiP93025

Proteomic databases

PaxDbiP93025
PRIDEiP93025
ProteomicsDBi235062 [P93025-1]

Genome annotation databases

EnsemblPlantsiAT5G58140.1; AT5G58140.1; AT5G58140 [P93025-1]
AT5G58140.2; AT5G58140.2; AT5G58140 [P93025-1]
AT5G58140.5; AT5G58140.5; AT5G58140 [P93025-1]
AT5G58140.6; AT5G58140.6; AT5G58140 [P93025-1]
AT5G58140.7; AT5G58140.7; AT5G58140 [P93025-1]
GeneIDi835926
GrameneiAT5G58140.1; AT5G58140.1; AT5G58140 [P93025-1]
AT5G58140.2; AT5G58140.2; AT5G58140 [P93025-1]
AT5G58140.5; AT5G58140.5; AT5G58140 [P93025-1]
AT5G58140.6; AT5G58140.6; AT5G58140 [P93025-1]
AT5G58140.7; AT5G58140.7; AT5G58140 [P93025-1]
KEGGiath:AT5G58140

Organism-specific databases

AraportiAT5G58140
TAIRilocus:2155821, AT5G58140

Phylogenomic databases

eggNOGiENOG502QPPH, Eukaryota
HOGENOMiCLU_006321_0_1_1
InParanoidiP93025
KOiK20715
PhylomeDBiP93025

Miscellaneous databases

EvolutionaryTraceiP93025

Protein Ontology

More...PROi		PR:P93025

Gene expression databases

ExpressionAtlasiP93025, baseline and differential
GenevisibleiP93025, AT

Family and domain databases

CDDicd00130, PAS, 2 hits
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR001610, PAC
IPR000014, PAS
IPR000700, PAS-assoc_C
IPR035965, PAS-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF13426, PAS_9, 2 hits
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00086, PAC, 2 hits
SM00091, PAS, 2 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF55785, SSF55785, 2 hits
SSF56112, SSF56112, 1 hit
TIGRFAMsiTIGR00229, sensory_box, 2 hits
PROSITEiView protein in PROSITE
PS50113, PAC, 2 hits
PS50112, PAS, 2 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHOT2_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P93025
Secondary accession number(s): O81204, Q8RWE6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: October 7, 2020
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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