UniProtKB - P93024 (ARFE_ARATH)
Auxin response factor 5
ARF5
Functioni
Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Mediates embryo axis formation and vascular tissues differentiation. Functionally redundant with ARF7. May be necessary to counteract AMP1 activity.
3 PublicationsMiscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 158 – 260 | TF-B3PROSITE-ProRule annotationAdd BLAST | 103 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: TAIR
- identical protein binding Source: IntAct
- transcription cis-regulatory region binding Source: TAIR
GO - Biological processi
- auxin-activated signaling pathway Source: UniProtKB-KW
- embryo development ending in seed dormancy Source: TAIR
- flower development Source: TAIR
- leaf vascular tissue pattern formation Source: TAIR
- longitudinal axis specification Source: TAIR
- meristem development Source: TAIR
- regulation of transcription, DNA-templated Source: TAIR
- response to auxin Source: TAIR
- root development Source: TAIR
- xylem and phloem pattern formation Source: TAIR
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Auxin signaling pathway, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Auxin response factor 5Alternative name(s): Auxin-responsive protein IAA24 Transcription factor MONOPTEROS |
Gene namesi | Name:ARF5 Synonyms:IAA24, MP Ordered Locus Names:At1g19850 ORF Names:F6F9.10 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT1G19850 |
TAIRi | locus:2035454, AT1G19850 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000111509 | 1 – 902 | Auxin response factor 5Add BLAST | 902 |
Proteomic databases
PaxDbi | P93024 |
ProteomicsDBi | 246991 |
PTM databases
iPTMneti | P93024 |
MetOSitei | P93024 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
ExpressionAtlasi | P93024, baseline and differential |
Genevisiblei | P93024, AT |
Interactioni
Subunit structurei
Homodimers and heterodimers.
Interacts with BRX and the auxin-responsive proteins IAA1, IAA12 (BODENLOS), IAA17 and ARF7.
3 PublicationsBinary interactionsi
P93024
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 23812, 38 interactors |
IntActi | P93024, 36 interactors |
STRINGi | 3702.AT1G19850.1 |
Structurei
Secondary structure
3D structure databases
SMRi | P93024 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 793 – 877 | PB1PROSITE-ProRule annotationAdd BLAST | 85 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 497 – 543 | DisorderedSequence analysisAdd BLAST | 47 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QQ0Y, Eukaryota |
HOGENOMi | CLU_002626_2_1_1 |
InParanoidi | P93024 |
OrthoDBi | 155049at2759 |
PhylomeDBi | P93024 |
Family and domain databases
CDDi | cd10017, B3_DNA, 1 hit |
Gene3Di | 2.40.330.10, 1 hit |
InterProi | View protein in InterPro IPR010525, ARF_dom IPR044835, ARF_plant IPR033389, AUX/IAA_dom IPR003340, B3_DNA-bd IPR015300, DNA-bd_pseudobarrel_sf IPR000270, PB1_dom |
PANTHERi | PTHR31384, PTHR31384, 1 hit |
Pfami | View protein in Pfam PF02309, AUX_IAA, 1 hit PF06507, Auxin_resp, 1 hit PF02362, B3, 1 hit |
SMARTi | View protein in SMART SM01019, B3, 1 hit |
SUPFAMi | SSF101936, SSF101936, 1 hit |
PROSITEi | View protein in PROSITE PS50863, B3, 1 hit PS51745, PB1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MMASLSCVED KMKTSCLVNG GGTITTTTSQ STLLEEMKLL KDQSGTRKPV
60 70 80 90 100
INSELWHACA GPLVCLPQVG SLVYYFSQGH SEQVAVSTRR SATTQVPNYP
110 120 130 140 150
NLPSQLMCQV HNVTLHADKD SDEIYAQMSL QPVHSERDVF PVPDFGMLRG
160 170 180 190 200
SKHPTEFFCK TLTASDTSTH GGFSVPRRAA EKLFPPLDYS AQPPTQELVV
210 220 230 240 250
RDLHENTWTF RHIYRGQPKR HLLTTGWSLF VGSKRLRAGD SVLFIRDEKS
260 270 280 290 300
QLMVGVRRAN RQQTALPSSV LSADSMHIGV LAAAAHATAN RTPFLIFYNP
310 320 330 340 350
RACPAEFVIP LAKYRKAICG SQLSVGMRFG MMFETEDSGK RRYMGTIVGI
360 370 380 390 400
SDLDPLRWPG SKWRNLQVEW DEPGCNDKPT RVSPWDIETP ESLFIFPSLT
410 420 430 440 450
SGLKRQLHPS YFAGETEWGS LIKRPLIRVP DSANGIMPYA SFPSMASEQL
460 470 480 490 500
MKMMMRPHNN QNVPSFMSEM QQNIVMGNGG LLGDMKMQQP LMMNQKSEMV
510 520 530 540 550
QPQNKLTVNP SASNTSGQEQ NLSQSMSAPA KPENSTLSGC SSGRVQHGLE
560 570 580 590 600
QSMEQASQVT TSTVCNEEKV NQLLQKPGAS SPVQADQCLD ITHQIYQPQS
610 620 630 640 650
DPINGFSFLE TDELTSQVSS FQSLAGSYKQ PFILSSQDSS AVVLPDSTNS
660 670 680 690 700
PLFHDVWDTQ LNGLKFDQFS PLMQQDLYAS QNICMSNSTT SNILDPPLSN
710 720 730 740 750
TVLDDFCAIK DTDFQNHPSG CLVGNNNTSF AQDVQSQITS ASFADSQAFS
760 770 780 790 800
RQDFPDNSGG TGTSSSNVDF DDCSLRQNSK GSSWQKIATP RVRTYTKVQK
810 820 830 840 850
TGSVGRSIDV TSFKDYEELK SAIECMFGLE GLLTHPQSSG WKLVYVDYES
860 870 880 890 900
DVLLVGDDPW EEFVGCVRCI RILSPTEVQQ MSEEGMKLLN SAGINDLKTS
VS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1P8AQ60 | A0A1P8AQ60_ARATH | Auxin response factor | MP ARF5, AUXIN RESPONSE FACTOR 5, IAA24, MONOPTEROS, TRANSCRIPTION FACTOR IAA24 | 891 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 439 | Y → F in strain; cv. Ag-0. 1 Publication | 1 | |
Natural varianti | 526 | M → T in strain: cv. Cvi-1. 1 Publication | 1 | |
Natural varianti | 539 – 542 | Missing in strain: cv. Kas-1. | 4 | |
Natural varianti | 796 | T → I1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF037228 Genomic DNA Translation: AAC39410.1 AF037229 mRNA Translation: AAC60794.1 AC007797 Genomic DNA Translation: AAG12546.1 Sequence problems. CP002684 Genomic DNA Translation: AEE29906.1 AF334716 mRNA Translation: AAG50094.1 BT002050 mRNA Translation: AAN72061.1 BT008805 mRNA Translation: AAP68244.1 AB199792 mRNA Translation: BAE48152.1 U79557 mRNA Translation: AAB92476.1 EF598523 Genomic DNA Translation: ABR09007.1 EF598524 Genomic DNA Translation: ABR09008.1 EF598525 Genomic DNA Translation: ABR09009.1 EF598526 Genomic DNA Translation: ABR09010.1 EF598527 Genomic DNA Translation: ABR09011.1 EF598528 Genomic DNA Translation: ABR09012.1 EF598529 Genomic DNA Translation: ABR09013.1 EF598530 Genomic DNA Translation: ABR09014.1 EF598531 Genomic DNA Translation: ABR09015.1 EF598532 Genomic DNA Translation: ABR09016.1 EF598533 Genomic DNA Translation: ABR09017.1 EF598534 Genomic DNA Translation: ABR09018.1 EF598535 Genomic DNA Translation: ABR09019.1 EF598536 Genomic DNA Translation: ABR09020.1 EF598537 Genomic DNA Translation: ABR09021.1 EF598538 Genomic DNA Translation: ABR09022.1 EF598539 Genomic DNA Translation: ABR09023.1 EF598540 Genomic DNA Translation: ABR09024.1 EF598541 Genomic DNA Translation: ABR09025.1 EF598542 Genomic DNA Translation: ABR09026.1 EF598543 Genomic DNA Translation: ABR09027.1 EF598544 Genomic DNA Translation: ABR09028.1 EF598545 Genomic DNA Translation: ABR09029.1 EF598546 Genomic DNA Translation: ABR09030.1 |
PIRi | G86331 T51807 |
RefSeqi | NP_173414.1, NM_101840.3 |
Genome annotation databases
EnsemblPlantsi | AT1G19850.1; AT1G19850.1; AT1G19850 |
GeneIDi | 838573 |
Gramenei | AT1G19850.1; AT1G19850.1; AT1G19850 |
KEGGi | ath:AT1G19850 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF037228 Genomic DNA Translation: AAC39410.1 AF037229 mRNA Translation: AAC60794.1 AC007797 Genomic DNA Translation: AAG12546.1 Sequence problems. CP002684 Genomic DNA Translation: AEE29906.1 AF334716 mRNA Translation: AAG50094.1 BT002050 mRNA Translation: AAN72061.1 BT008805 mRNA Translation: AAP68244.1 AB199792 mRNA Translation: BAE48152.1 U79557 mRNA Translation: AAB92476.1 EF598523 Genomic DNA Translation: ABR09007.1 EF598524 Genomic DNA Translation: ABR09008.1 EF598525 Genomic DNA Translation: ABR09009.1 EF598526 Genomic DNA Translation: ABR09010.1 EF598527 Genomic DNA Translation: ABR09011.1 EF598528 Genomic DNA Translation: ABR09012.1 EF598529 Genomic DNA Translation: ABR09013.1 EF598530 Genomic DNA Translation: ABR09014.1 EF598531 Genomic DNA Translation: ABR09015.1 EF598532 Genomic DNA Translation: ABR09016.1 EF598533 Genomic DNA Translation: ABR09017.1 EF598534 Genomic DNA Translation: ABR09018.1 EF598535 Genomic DNA Translation: ABR09019.1 EF598536 Genomic DNA Translation: ABR09020.1 EF598537 Genomic DNA Translation: ABR09021.1 EF598538 Genomic DNA Translation: ABR09022.1 EF598539 Genomic DNA Translation: ABR09023.1 EF598540 Genomic DNA Translation: ABR09024.1 EF598541 Genomic DNA Translation: ABR09025.1 EF598542 Genomic DNA Translation: ABR09026.1 EF598543 Genomic DNA Translation: ABR09027.1 EF598544 Genomic DNA Translation: ABR09028.1 EF598545 Genomic DNA Translation: ABR09029.1 EF598546 Genomic DNA Translation: ABR09030.1 |
PIRi | G86331 T51807 |
RefSeqi | NP_173414.1, NM_101840.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4CHK | X-ray | 2.85 | A/B/C/D/E/F/G/H | 779-902 | [»] | |
4LDU | X-ray | 2.15 | A | 1-390 | [»] | |
6L5K | X-ray | 2.91 | A | 788-885 | [»] | |
SMRi | P93024 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 23812, 38 interactors |
IntActi | P93024, 36 interactors |
STRINGi | 3702.AT1G19850.1 |
PTM databases
iPTMneti | P93024 |
MetOSitei | P93024 |
Proteomic databases
PaxDbi | P93024 |
ProteomicsDBi | 246991 |
Genome annotation databases
EnsemblPlantsi | AT1G19850.1; AT1G19850.1; AT1G19850 |
GeneIDi | 838573 |
Gramenei | AT1G19850.1; AT1G19850.1; AT1G19850 |
KEGGi | ath:AT1G19850 |
Organism-specific databases
Araporti | AT1G19850 |
TAIRi | locus:2035454, AT1G19850 |
Phylogenomic databases
eggNOGi | ENOG502QQ0Y, Eukaryota |
HOGENOMi | CLU_002626_2_1_1 |
InParanoidi | P93024 |
OrthoDBi | 155049at2759 |
PhylomeDBi | P93024 |
Miscellaneous databases
PROi | PR:P93024 |
Gene expression databases
ExpressionAtlasi | P93024, baseline and differential |
Genevisiblei | P93024, AT |
Family and domain databases
CDDi | cd10017, B3_DNA, 1 hit |
Gene3Di | 2.40.330.10, 1 hit |
InterProi | View protein in InterPro IPR010525, ARF_dom IPR044835, ARF_plant IPR033389, AUX/IAA_dom IPR003340, B3_DNA-bd IPR015300, DNA-bd_pseudobarrel_sf IPR000270, PB1_dom |
PANTHERi | PTHR31384, PTHR31384, 1 hit |
Pfami | View protein in Pfam PF02309, AUX_IAA, 1 hit PF06507, Auxin_resp, 1 hit PF02362, B3, 1 hit |
SMARTi | View protein in SMART SM01019, B3, 1 hit |
SUPFAMi | SSF101936, SSF101936, 1 hit |
PROSITEi | View protein in PROSITE PS50863, B3, 1 hit PS51745, PB1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARFE_ARATH | |
Accessioni | P93024Primary (citable) accession number: P93024 Secondary accession number(s): A5YYU1 Q9FXI3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 27, 2002 |
Last sequence update: | May 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families