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Entry version 138 (02 Dec 2020)
Sequence version 1 (01 May 1997)
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Protein

DNA-directed RNA polymerase 1, mitochondrial

Gene

RPOT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei677By similarity1
Active sitei752By similarity1
Active sitei909By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase 1, mitochondrial (EC:2.7.7.6)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPOT1
Synonyms:RPOMT
Ordered Locus Names:At1g68990
ORF Names:T6L1.17
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G68990

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 42MitochondrionSequence analysisAdd BLAST42
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003107043 – 976DNA-directed RNA polymerase 1, mitochondrialAdd BLAST934

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P92969

PRoteomics IDEntifications database

More...
PRIDEi
P92969

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
228233 [P92969-1]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P92969, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P92969, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G68990.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P92969

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1038, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003364_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P92969

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHEVRIQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P92969

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1320.10, 1 hit
1.10.287.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024075, DNA-dir_RNA_pol_helix_hairp_sf
IPR002092, DNA-dir_Rpol_phage-type
IPR043502, DNA/RNA_pol_sf
IPR037159, RNA_POL_N_sf
IPR029262, RPOL_N

The PANTHER Classification System

More...
PANTHERi
PTHR10102, PTHR10102, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00940, RNA_pol, 1 hit
PF14700, RPOL_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01311, RPOL_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00900, RNA_POL_PHAGE_1, 1 hit
PS00489, RNA_POL_PHAGE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. According to EST sequences.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P92969-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWRNILGRAS LRKVKFLSDS SSSGTHYPVN RVRGILSSVN LSGVRNGLSI
60 70 80 90 100
NPVNEMGGLS SFRHGQCYVF EGYATAAQAI DSTDPEDESS GSDEVNELIT
110 120 130 140 150
EMEKETERIR KKARLAAIPP KRVIAGMGAQ KFYMLKQRQV KMETEEWERA
160 170 180 190 200
ARECREILAD MCEQKLAPNL PYMKSLFLGW FEPVRNAIQD DLDTFKIKKG
210 220 230 240 250
KIPYAPFMEQ LPADKMAVIT MHKMMGLLMT NAEGVGIVKL VNAATQIGEA
260 270 280 290 300
VEQEVRINSF LQKKNKKNAT DKTINTEAEN VSEEIVAKET EKARKQVTVL
310 320 330 340 350
MEKNKLRQVK ALVRKHDSFK PWGQEAQVKV GARLIQLLME NAYIQPPAEQ
360 370 380 390 400
FDDGPPDIRP AFKQNFRTVT LENTKTSRRY GCIECDPLVL KGLDKSARHM
410 420 430 440 450
VIPYLPMLIP PQNWTGYDQG AHFFLPSYVM RTHGAKQQRT VMKRTPKEQL
460 470 480 490 500
EPVYEALDTL GNTKWKINKK VLSLVDRIWA NGGRIGGLVD REDVPIPEEP
510 520 530 540 550
EREDQEKFKN WRWESKKAIK QNNERHSQRC DIELKLEVAR KMKDEEGFYY
560 570 580 590 600
PHNVDFRGRA YPIHPYLNHL GSDLCRGILE FCEGKPLGKS GLRWLKIHIA
610 620 630 640 650
NLYAGGVDKL AYEDRIAFTE SHLEDIFDSS DRPLEGKRWW LNAEDPFQCL
660 670 680 690 700
AACINLSEAL RSPFPEAAIS HIPIHQDGSC NGLQHYAALG RDKLGADAVN
710 720 730 740 750
LVTGEKPADV YTEIAARVLK IMQQDAEEDP ETFPNATYAK LMLDQVDRKL
760 770 780 790 800
VKQTVMTSVY GVTYSGARDQ IKKRLKERGT FEDDSLTFHA SCYAAKITLK
810 820 830 840 850
ALEEMFEAAR AIKSWFGDCA KIIASENNAV CWTTPLGLPV VQPYRKPGRH
860 870 880 890 900
LVKTTLQVLT LSRETDKVMA RRQMTAFAPN FIHSLDGSHM MMTAVACNRA
910 920 930 940 950
GLSFAGVHDS FWTHACDVDV MNTILREKFV ELYEKPILEN LLESFQKSFP
960 970
DISFPPLPER GDFDLRKVLE STYFFN
Length:976
Mass (Da):110,930
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75DFCF64465450D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F4I0I3F4I0I3_ARATH
DNA-directed RNA polymerase
MGP3 male gametophyte defective 3, At1g68990, T6L1.17, T6L1_17
983Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti498E → V in CAA69331 (PubMed:9242608).Curated1
Sequence conflicti766G → S in CAA69331 (PubMed:9242608).Curated1
Sequence conflicti920V → I in CAA69331 (PubMed:9242608).Curated1
Sequence conflicti924I → V in CAA69331 (PubMed:9242608).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y08137 mRNA Translation: CAA69331.1
Y09006 Genomic DNA Translation: CAA70210.1
Y09432 Genomic DNA Translation: CAA70583.1
AC011665 Genomic DNA Translation: AAG51592.1
CP002684 Genomic DNA Translation: AEE34873.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D96714

NCBI Reference Sequences

More...
RefSeqi
NP_177063.1, NM_105571.4 [P92969-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G68990.1; AT1G68990.1; AT1G68990 [P92969-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
843232

Gramene; a comparative resource for plants

More...
Gramenei
AT1G68990.1; AT1G68990.1; AT1G68990 [P92969-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G68990

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08137 mRNA Translation: CAA69331.1
Y09006 Genomic DNA Translation: CAA70210.1
Y09432 Genomic DNA Translation: CAA70583.1
AC011665 Genomic DNA Translation: AAG51592.1
CP002684 Genomic DNA Translation: AEE34873.1
PIRiD96714
RefSeqiNP_177063.1, NM_105571.4 [P92969-1]

3D structure databases

SMRiP92969
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G68990.2

Proteomic databases

PaxDbiP92969
PRIDEiP92969
ProteomicsDBi228233 [P92969-1]

Genome annotation databases

EnsemblPlantsiAT1G68990.1; AT1G68990.1; AT1G68990 [P92969-1]
GeneIDi843232
GrameneiAT1G68990.1; AT1G68990.1; AT1G68990 [P92969-1]
KEGGiath:AT1G68990

Organism-specific databases

AraportiAT1G68990

Phylogenomic databases

eggNOGiKOG1038, Eukaryota
HOGENOMiCLU_003364_4_0_1
InParanoidiP92969
OMAiEHEVRIQ
PhylomeDBiP92969

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P92969

Gene expression databases

ExpressionAtlasiP92969, baseline and differential
GenevisibleiP92969, AT

Family and domain databases

Gene3Di1.10.1320.10, 1 hit
1.10.287.260, 1 hit
InterProiView protein in InterPro
IPR024075, DNA-dir_RNA_pol_helix_hairp_sf
IPR002092, DNA-dir_Rpol_phage-type
IPR043502, DNA/RNA_pol_sf
IPR037159, RNA_POL_N_sf
IPR029262, RPOL_N
PANTHERiPTHR10102, PTHR10102, 1 hit
PfamiView protein in Pfam
PF00940, RNA_pol, 1 hit
PF14700, RPOL_N, 1 hit
SMARTiView protein in SMART
SM01311, RPOL_N, 1 hit
SUPFAMiSSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS00900, RNA_POL_PHAGE_1, 1 hit
PS00489, RNA_POL_PHAGE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOT1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P92969
Secondary accession number(s): O23698
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: December 2, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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