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Protein

Soluble guanylate cyclase gcy-34

Gene

gcy-34

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP (PubMed:23874221).By similarity1 Publication

Miscellaneous

There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

Cofactori

hemeBy similarityNote: Binds 1 or 2 heme groups per heterodimer.By similarity

Enzyme regulationi

May be regulated by molecular oxygen. Probably not activated by nitric oxide (NO) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi105Iron (heme proximal ligand)By similarity1
Metal bindingi460MagnesiumBy similarity1
Metal bindingi504MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cGMP biosynthetic process Source: GO_Central
  • chemosensory behavior Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • sensory perception of bitter taste Source: UniProtKB
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionLyase
Biological processcGMP biosynthesis
LigandGTP-binding, Heme, Iron, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble guanylate cyclase gcy-34 (EC:4.6.1.2)
Gene namesi
Name:gcy-34
ORF Names:M04G12.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiM04G12.3 ; CE12426 ; WBGene00001554 ; gcy-34

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000741251 – 686Soluble guanylate cyclase gcy-34Add BLAST686

Proteomic databases

PaxDbiP92006
PRIDEiP92006

Expressioni

Tissue specificityi

Expressed in a small number of neurons, corresponding to URX, AQR and PQR neurons.1 Publication

Gene expression databases

BgeeiWBGene00001554

Interactioni

Subunit structurei

Heterodimer; with other soluble guanylate cyclases.By similarity

Protein-protein interaction databases

STRINGi6239.M04G12.3

Structurei

3D structure databases

ProteinModelPortaliP92006
SMRiP92006
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini455 – 583Guanylate cyclasePROSITE-ProRule annotationAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili306 – 335Sequence analysisAdd BLAST30
Coiled coili398 – 432Sequence analysisAdd BLAST35

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4171 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000118959
HOGENOMiHOG000220903
InParanoidiP92006
KOiK01769
OMAiGCHLKLK
OrthoDBiEOG091G07GF
PhylomeDBiP92006

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
3.90.1520.10, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR038158 H-NOX_domain_sf
IPR011644 Heme_NO-bd
IPR011645 HNOB_dom_associated
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
PF07700 HNOB, 1 hit
PF07701 HNOBA, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P92006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGFIHESIR QLVIRKYGED VWLQVLERSG FENGKENIVN HYYSDTDTYV
60 70 80 90 100
LVDSVSIVLK VTKDQIWEMY GGFLITYSME IGWDELVRSM SPNLKGFLDN
110 120 130 140 150
LDSLHYFIDH VVYKANLRGP SFRCEENPDG TLMLHYFTGR PGLYHIVKGV
160 170 180 190 200
VKEVAKLVFN LDISLVVQGR TQRSVHMNNG ERVEEHVIFL IKNVEEPRRD
210 220 230 240 250
SDTSTTSALT SVEPDFGEII DDNLKVSLQD FSRALPYHFV LDESCRLVQC
260 270 280 290 300
GDELYNHIPN ELLQPGTPIL RIFEINRPQI PLDFENICNF INAVFVLQVK
310 320 330 340 350
TSPLRKKHMN AMTKEEREQE VEAMEEEVES NELTQGCHLK LKGQMMMLST
360 370 380 390 400
KKHIIYLCSP YVTSINELMQ FGMRLTAMPL HDATRDLILL NQQRLSDVEV
410 420 430 440 450
NLQLEANNEQ LETMTHELEV ERQKTDSILK DMLPRKIAKQ LLSGEHLEPC
460 470 480 490 500
EYEATVMFCD LPAFQQIIPV CQPKNIVKLL NEVFFKLDRI VVLRGVYKVE
510 520 530 540 550
TVSDSYMTVS GIPDYTSEHA ENMCHVALGM MWEARSVMDP VNKTPFLLRI
560 570 580 590 600
GLHSGTIIAG VVGTKMPRYC LFGETVTLAS QMESLGVAGK IQCSSWTYSK
610 620 630 640 650
AMETGRFEFS PRGRINVKGR GDVETYFLMR SLKKSIWEIT DHERDVNVNS
660 670 680
IEGYEELEIF IENAQTVKHD GHPKANQNHS ATCTIA
Length:686
Mass (Da):78,588
Last modified:May 1, 1997 - v1
Checksum:i65AE352DB53CBA57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY652943 mRNA Translation: AAT73710.1
Z81103 Genomic DNA Translation: CAB03210.1
PIRiT23721
RefSeqiNP_506319.1, NM_073918.5
UniGeneiCel.36199

Genome annotation databases

EnsemblMetazoaiM04G12.3; M04G12.3; WBGene00001554
GeneIDi191656
KEGGicel:CELE_M04G12.3
UCSCiM04G12.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiGCY34_CAEEL
AccessioniPrimary (citable) accession number: P92006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: May 1, 1997
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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