UniProtKB - P91929 (NDUAA_DROME)
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
ND-42
Functioni
Cofactori
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: FlyBase
- NADH dehydrogenase activity Source: FlyBase
GO - Biological processi
- mitochondrial electron transport, NADH to ubiquinone Source: FlyBase
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
Reactomei | R-DME-611105, Respiratory electron transport R-DME-6799198, Complex I biogenesis |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialAlternative name(s): Complex I-42kD Short name: CI-42kD NADH-ubiquinone oxidoreductase 42 kDa subunit |
Gene namesi | ORF Names:CG6343Imported |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0019957, ND-42 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 2 Publications
Other locations
- Cytoplasm 1 Publication
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
- mitochondrial respiratory chain complex I Source: FlyBase
- mitochondrion Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, MitochondrionPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 1 – 47 | Missing : Localizes to cytoplasm. 1 PublicationAdd BLAST | 47 | |
Mutagenesisi | 281 | S → A: Does not rescue the phenotype of Pink1-null mutants which are unable to maintain neurotransmitter release at neuromuscular junctions (NMJ) during high-frequency stimulation (10 Hz). Rescues the climbing deficit of Pink1-null mutants. 2 Publications | 1 | |
Mutagenesisi | 281 | S → D: Rescues some phenotypes of Pink1-null mutants by re-enabling maintained neurotransmitter release at neuromuscular junctions (NMJ) during high-frequency stimulation (10 Hz), by restoring mitochondria cristae structural organization and by improving climbing activity; does not restore muscle morphology and rescues only partially flight defects in the same mutants. 2 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 60 | MitochondrionSequence analysis1 PublicationAdd BLAST | 60 | |
ChainiPRO_0000019990 | 61 – 407 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialAdd BLAST | 347 |
Proteomic databases
PaxDbi | P91929 |
PRIDEi | P91929 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | FBgn0019957, Expressed in mouthpart (Drosophila) and 53 other tissues |
ExpressionAtlasi | P91929, baseline and differential |
Genevisiblei | P91929, DM |
Interactioni
Subunit structurei
Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction (PubMed:28683319).
Forms a complex including sicily, ND-42 and Hsp83; the complex is necessary to chaperone ND-42 in the cytoplasm before mitochondrial import; the interaction between sicily and ND-42 is direct and occurs preferably between the unprocessed forms in the cytoplasm (PubMed:23509070).
2 PublicationsProtein-protein interaction databases
BioGRIDi | 67552, 17 interactors |
DIPi | DIP-21667N |
IntActi | P91929, 3 interactors |
STRINGi | 7227.FBpp0083570 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3877, Eukaryota |
GeneTreei | ENSGT00390000016151 |
HOGENOMi | CLU_050591_1_0_1 |
InParanoidi | P91929 |
OMAi | CHEKPDL |
OrthoDBi | 1147235at2759 |
PhylomeDBi | P91929 |
Family and domain databases
CDDi | cd02030, NDUO42, 1 hit |
InterProi | View protein in InterPro IPR031314, DNK_dom IPR015828, NDUFA10 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01712, dNK, 1 hit |
PIRSFi | PIRSF000543, NADH_UQ_42KD, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MTAVFRVGLV RLVSRATQSP NLLQAQTNAL PAAFQQRCSI SGKTMRGGPR
60 70 80 90 100
VPKAAPYPYK TKKYSVFNAI FDKTSKRFDE NSKVICVEGP IAAGKSKFAK
110 120 130 140 150
ELAEELDMEY YPAVDLDLIY INSYGYDMRK LDPQLPPSCR SYDVRNFCLD
160 170 180 190 200
PSHDLAAQFQ IRMYMLRYSQ YIDALQHVLS TGQGVVLERS PYSDFVFMEA
210 220 230 240 250
MFRQGYLSRG ARSVYNELRQ NTIGELLKPH LVIYLDLPVD AVKKQIKARN
260 270 280 290 300
VDYEVQSKVF SDAYLSDLEQ LYKQQYLKDI STHAELLIYD WTAGGETEVV
310 320 330 340 350
VEDIERIDFN QFEADIHNKK MLDWRFPLEA EWCEARIKYC HEKPDLMNYF
360 370 380 390 400
NVPRFDVPEL VRSADDGKVW RDVWFNAPGM KYRPGYNADM GDEGLLTKTK
IGINQGI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA4V383 | A4V383_DROME | NADH dehydrogenase [ubiquinone] 1 a... | ND-42 A10, Dmel\CG6343, ND42, NdufA10, NUDM | 407 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 177 | H → R in CAA71852 (PubMed:10071211).Curated | 1 | |
Sequence conflicti | 198 | M → L in CAA71852 (PubMed:10071211).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55947.1 AY051764 mRNA Translation: AAK93188.1 Y10911 mRNA Translation: CAA71852.1 |
RefSeqi | NP_001262821.1, NM_001275892.1 NP_524445.1, NM_079721.4 NP_732692.1, NM_169990.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0084172; FBpp0083570; FBgn0019957 FBtr0084173; FBpp0083571; FBgn0019957 FBtr0335194; FBpp0307181; FBgn0019957 |
GeneIDi | 42591 |
KEGGi | dme:Dmel_CG6343 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF55947.1 AY051764 mRNA Translation: AAK93188.1 Y10911 mRNA Translation: CAA71852.1 |
RefSeqi | NP_001262821.1, NM_001275892.1 NP_524445.1, NM_079721.4 NP_732692.1, NM_169990.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 67552, 17 interactors |
DIPi | DIP-21667N |
IntActi | P91929, 3 interactors |
STRINGi | 7227.FBpp0083570 |
Proteomic databases
PaxDbi | P91929 |
PRIDEi | P91929 |
Genome annotation databases
EnsemblMetazoai | FBtr0084172; FBpp0083570; FBgn0019957 FBtr0084173; FBpp0083571; FBgn0019957 FBtr0335194; FBpp0307181; FBgn0019957 |
GeneIDi | 42591 |
KEGGi | dme:Dmel_CG6343 |
Organism-specific databases
CTDi | 42591 |
FlyBasei | FBgn0019957, ND-42 |
Phylogenomic databases
eggNOGi | KOG3877, Eukaryota |
GeneTreei | ENSGT00390000016151 |
HOGENOMi | CLU_050591_1_0_1 |
InParanoidi | P91929 |
OMAi | CHEKPDL |
OrthoDBi | 1147235at2759 |
PhylomeDBi | P91929 |
Enzyme and pathway databases
Reactomei | R-DME-611105, Respiratory electron transport R-DME-6799198, Complex I biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 42591, 0 hits in 3 CRISPR screens |
GenomeRNAii | 42591 |
PROi | PR:P91929 |
Gene expression databases
Bgeei | FBgn0019957, Expressed in mouthpart (Drosophila) and 53 other tissues |
ExpressionAtlasi | P91929, baseline and differential |
Genevisiblei | P91929, DM |
Family and domain databases
CDDi | cd02030, NDUO42, 1 hit |
InterProi | View protein in InterPro IPR031314, DNK_dom IPR015828, NDUFA10 IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01712, dNK, 1 hit |
PIRSFi | PIRSF000543, NADH_UQ_42KD, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NDUAA_DROME | |
Accessioni | P91929Primary (citable) accession number: P91929 Secondary accession number(s): Q9VD54 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families