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Protein

Probable phosphoserine aminotransferase

Gene

F26H9.5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.By similarity

Catalytic activityi

O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate.
4-phosphonooxy-L-threonine + 2-oxoglutarate = (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate.

Cofactori

pyridoxal 5'-phosphateBy similarityNote: Binds 1 pyridoxal phosphate per subunit.By similarity

Pathwayi: L-serine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-serine from 3-phospho-D-glycerate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable phosphoserine aminotransferase (F26H9.5)
  3. no protein annotated in this organism
This subpathway is part of the pathway L-serine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-serine from 3-phospho-D-glycerate, the pathway L-serine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable phosphoserine aminotransferase (F26H9.5)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei45L-glutamateBy similarity1
Binding sitei105Pyridoxal phosphateBy similarity1
Binding sitei154Pyridoxal phosphateBy similarity1
Binding sitei175Pyridoxal phosphateBy similarity1
Binding sitei198Pyridoxal phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Serine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-CEL-977347 Serine biosynthesis
UniPathwayiUPA00135; UER00197
UPA00244; UER00311

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoserine aminotransferase (EC:2.6.1.52)
Short name:
PSAT
Alternative name(s):
Phosphohydroxythreonine aminotransferase
Gene namesi
ORF Names:F26H9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF26H9.5 ; CE09710 ; WBGene00009177

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001501381 – 370Probable phosphoserine aminotransferaseAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

EPDiP91856
PaxDbiP91856
PeptideAtlasiP91856
PRIDEiP91856

Expressioni

Gene expression databases

BgeeiWBGene00009177

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6239.F26H9.5

Structurei

3D structure databases

ProteinModelPortaliP91856
SMRiP91856
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 80Pyridoxal phosphate bindingBy similarity2
Regioni240 – 241Pyridoxal phosphate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2790 Eukaryota
COG1932 LUCA
GeneTreeiENSGT00390000015177
HOGENOMiHOG000088965
InParanoidiP91856
KOiK00831
OMAiGAQKNMG
OrthoDBiEOG091G0964
PhylomeDBiP91856

Family and domain databases

CDDicd00611 PSAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00160 SerC_aminotrans_5, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR020578 Aminotrans_V_PyrdxlP_BS
IPR022278 Pser_aminoTfrase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF000525 SerC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01364 serC_1, 1 hit
PROSITEiView protein in PROSITE
PS00595 AA_TRANSFER_CLASS_5, 1 hit

Sequencei

Sequence statusi: Complete.

P91856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGRKINF AAGPAKLPEE VLLKMQEEQL NFNNLGVSVI EMSHRSKEFG
60 70 80 90 100
ALLNETISLI RELMNVPDNF EILFMQGGGT GQFAAIPLNL KGDHEHADYI
110 120 130 140 150
VTGAWSSKAA DEAGKYINVK KVFQPSKPYV TVPDQENWVH DEKAAYLYYC
160 170 180 190 200
ANETVHGIEF TPTAPESHNV PLVADVSSNF MARPFDFKDH GVVFGGAQKN
210 220 230 240 250
LGAAGLTIVI VRKDLIGKQQ AITPSVFSYK EMIANNSLYN TPPTGGIYTT
260 270 280 290 300
NLVLKWIKSK GGLQAIYELN LQKSGMIYDI IDNSNGFYHC AVDKRYRSIM
310 320 330 340 350
NVCFRIGGPS GNDELEEKFL KGSIERNMIS LKGHRSVGGI RASLYNAISV
360 370
EETQVLATWM NEFQKLHNTN
Length:370
Mass (Da):41,002
Last modified:May 1, 1997 - v1
Checksum:i676735A56AEEAFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81516 Genomic DNA Translation: CAB04204.1
PIRiT21441
RefSeqiNP_492483.1, NM_060082.4
UniGeneiCel.18863

Genome annotation databases

EnsemblMetazoaiF26H9.5; F26H9.5; WBGene00009177
GeneIDi172756
KEGGicel:CELE_F26H9.5
UCSCiF26H9.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiSERC_CAEEL
AccessioniPrimary (citable) accession number: P91856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: February 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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