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Protein

Nuclear hormone receptor family member nhr-69

Gene

nhr-69

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi3 – 78Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri6 – 26NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri42 – 66NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • DNA binding transcription factor activity Source: InterPro
  • sequence-specific DNA binding Source: InterPro
  • SMAD binding Source: WormBase
  • steroid hormone binding Source: WormBase
  • steroid hormone receptor activity Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: WormBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-69
Gene namesi
Name:nhr-69
ORF Names:T23H4.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT23H4.2 ; CE32501 ; WBGene00003659 ; nhr-69

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537951 – 373Nuclear hormone receptor family member nhr-69Add BLAST373

Proteomic databases

EPDiP91829
PaxDbiP91829
PeptideAtlasiP91829

Expressioni

Gene expression databases

BgeeiWBGene00003659

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
tag-260P920043EBI-322112,EBI-316398

GO - Molecular functioni

  • SMAD binding Source: WormBase

Protein-protein interaction databases

BioGridi38263, 6 interactors
DIPiDIP-24463N
IntActiP91829, 6 interactors
MINTiP91829
STRINGi6239.T23H4.2

Structurei

3D structure databases

ProteinModelPortaliP91829
SMRiP91829
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 344NR LBDPROSITE-ProRule annotationAdd BLAST252

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri6 – 26NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri42 – 66NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4215 Eukaryota
ENOG410XQT8 LUCA
GeneTreeiENSGT00760000118948
HOGENOMiHOG000260822
InParanoidiP91829
KOiK07295
OMAiKRMRYQV
OrthoDBiEOG091G0A89
PhylomeDBiP91829

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P91829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEEICHICN DKSTGKHYGA ISCDGCKGFF RRSIRKRYHY QCRFEQNCDV
60 70 80 90 100
TKNKRNACRA CRLQKCVKAG MKSNAIQNER DAIGKRKKTT GAEKEDLIDQ
110 120 130 140 150
LVAAETLCQQ LRSSVIKNTS SLAPYDCGKV KWNYEDARAA TLDDIGKSIH
160 170 180 190 200
QQLVLFIEWA KSLPQFSFLA QADQAALLKG GAASIIVLGV AYRSICLTVE
210 220 230 240 250
NTICLANDTL LPKEHATQVG DINCVVGRII DEIVNPMRRL NMDLIEYVAL
260 270 280 290 300
KAILFFNPVV REINDQSPVE NARYAFLRSL QRRCTDKALE NMEDESMDCR
310 320 330 340 350
SGKLLLLLPS LQAIAQQLVE DVQLARLFGL VNVDSLMEEL ILNDMKPSDP
360 370
QILQTSLASP VNSSVKAEVE LEE
Length:373
Mass (Da):41,778
Last modified:March 1, 2003 - v2
Checksum:i469B4471C8FB30F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY204178 mRNA Translation: AAO39182.1
Z83240 Genomic DNA Translation: CAB05815.2
PIRiT25211
RefSeqiNP_492615.2, NM_060214.4
UniGeneiCel.18404

Genome annotation databases

EnsemblMetazoaiT23H4.2; T23H4.2; WBGene00003659
GeneIDi172840
KEGGicel:CELE_T23H4.2
UCSCiT23H4.2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiNHR69_CAEEL
AccessioniPrimary (citable) accession number: P91829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: July 18, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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