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Entry version 99 (02 Jun 2021)
Sequence version 2 (01 May 2000)
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Protein
Submitted name:

Voltage-dependent calcium channel

Gene
N/A
Organism
Heterololigo bleekeri (Spear squid) (Loligo bleekeri)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Voltage-dependent calcium channelImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHeterololigo bleekeri (Spear squid) (Loligo bleekeri)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1423826 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaCephalopodaColeoideaDecapodiformesTeuthidaMyopsinaLoliginidaeHeterololigo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei66 – 85HelicalSequence analysisAdd BLAST20
Transmembranei105 – 126HelicalSequence analysisAdd BLAST22
Transmembranei138 – 155HelicalSequence analysisAdd BLAST18
Transmembranei195 – 218HelicalSequence analysisAdd BLAST24
Transmembranei283 – 302HelicalSequence analysisAdd BLAST20
Transmembranei314 – 336HelicalSequence analysisAdd BLAST23
Transmembranei482 – 500HelicalSequence analysisAdd BLAST19
Transmembranei512 – 533HelicalSequence analysisAdd BLAST22
Transmembranei545 – 565HelicalSequence analysisAdd BLAST21
Transmembranei608 – 631HelicalSequence analysisAdd BLAST24
Transmembranei643 – 660HelicalSequence analysisAdd BLAST18
Transmembranei672 – 695HelicalSequence analysisAdd BLAST24
Transmembranei896 – 914HelicalSequence analysisAdd BLAST19
Transmembranei934 – 954HelicalSequence analysisAdd BLAST21
Transmembranei966 – 986HelicalSequence analysisAdd BLAST21
Transmembranei1030 – 1049HelicalSequence analysisAdd BLAST20
Transmembranei1140 – 1166HelicalSequence analysisAdd BLAST27
Transmembranei1223 – 1241HelicalSequence analysisAdd BLAST19
Transmembranei1253 – 1278HelicalSequence analysisAdd BLAST26
Transmembranei1284 – 1304HelicalSequence analysisAdd BLAST21
Transmembranei1346 – 1368HelicalSequence analysisAdd BLAST23
Transmembranei1433 – 1456HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1596 – 1630Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni768 – 864DisorderedSequence analysisAdd BLAST97
Regioni1737 – 1871DisorderedSequence analysisAdd BLAST135
Regioni1904 – 2093DisorderedSequence analysisAdd BLAST190
Regioni2147 – 2196DisorderedSequence analysisAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili344 – 364Sequence analysisAdd BLAST21
Coiled coili718 – 757Sequence analysisAdd BLAST40
Coiled coili1659 – 1686Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi777 – 802Polar residuesSequence analysisAdd BLAST26
Compositional biasi803 – 829Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi830 – 859Polar residuesSequence analysisAdd BLAST30
Compositional biasi1748 – 1770Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi1826 – 1842Polar residuesSequence analysisAdd BLAST17
Compositional biasi1955 – 1986Polar residuesSequence analysisAdd BLAST32

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167, CACHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P91744-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTFSADTGG RDDGDYTHDG SLQFVAKKAA TVSLPGMGSS TNRSLFIFSE
60 70 80 90 100
ENFIRKYAKI IIEWGPFEYM VLLTIIANCI VLALEEHLPN EDKTPLAVQL
110 120 130 140 150
EATEFYFLGI FCVEALLKIV ALGFALHKGS YLRNVWNIMD FVVVVTGFIS
160 170 180 190 200
IFPASNSFDL RTLRAVRVLR PLKLVSGIPS LQVVLKSIIR AMAPLLQVCL
210 220 230 240 250
LVLFAIVIFA IIGLEFYTGA FHKACFIKPN DDSEDNIEYG DEDTIRPCAN
260 270 280 290 300
EGSGYHCRAN IAKCRFNWAG PNYGITSFDN MGFAMLTVFQ CVTMEGWTQV
310 320 330 340 350
LYYTDDAVGD AYNWIYFVPL IVLGSFFMLN LVLGVLSGEF AKERERVENR
360 370 380 390 400
RAFLKLRRQQ QIERELNGYL EWICKAEEVI LDEERKKDDG TISDEDKLRI
410 420 430 440 450
IEGALGFNAR RLAAQKVKKM KENKELTIGD EDNDGDLLSG INVGGSFGRG
460 470 480 490 500
LKNRKAHGRC AGFWRAEKHL RFTIRKCVKT QGFYWFVIIL VFLNTLCVAS
510 520 530 540 550
EHYGQAEWHT EFLYVMEFAF LALFMSEMLI KMYGLGVRLY FQSSFNIFDC
560 570 580 590 600
VVILVSIIEV IWSAIKDGSS FGISTLRALR LLRMFKVTRY WSSLRNLVVS
610 620 630 640 650
LLSSMRSIVS LLFLLFLFIL IFALLGMQLF GGMMNFEEGR PPGHFDTFPI
660 670 680 690 700
ALLTVFQILT GEDWNEVMYS GIRARGGIAG GGMLYCSYFI ILVLFGNYTL
710 720 730 740 750
LNVFLAIAVD NLANAQELTA AEEIQEGVRQ EQEAAEKKKL AEEAAEKEKL
760 770 780 790 800
ARMEEIEKDL CPDQFGLTPP QVNICPPSPQ NNEDLKTGNF PYNTSRLDSN
810 820 830 840 850
LNQNNIKEER NKIGADKDLK KDRDPLDNVS LHESNANRNN AQPGSSSNLN
860 870 880 890 900
IQPQNGNSEE PAFGGPKPML PYSSMFIFGP TNPVRRFCHF VVNLRYFDLF
910 920 930 940 950
IMIVICASSI ALAAEDPVND ESVNNQILNY FDYVFTGVFT IEMLLKIVDL
960 970 980 990 1000
GIILHPGSYC RDAWNILDAT VVICALVAFA FGDAAGGNLN TIKSLRVLRV
1010 1020 1030 1040 1050
LRPLKTINRI PKLKAVFDCV VNSLKNVSNI LIVYLLFQFI FAVIAVQLFK
1060 1070 1080 1090 1100
GKFFYCTDMS KSNREECQGQ YFDYEDESDK PRVKNREWLR QDFHYDNVMF
1110 1120 1130 1140 1150
AMLTLFTVTT GEGWPMVLKN SMDSTSDDMG PKPGYRMEMA IYYVVFFIVF
1160 1170 1180 1190 1200
PFFFVNIFVA LIIITFQEQG ENELVDQDLD KNQKQCIEFS IEAKPSCRYV
1210 1220 1230 1240 1250
PKNKNSIKYK IWQVVVSPKF ECVVMVLIAL NTLVLMMKYY GSPTEYKLLL
1260 1270 1280 1290 1300
QNLNLAFSVL FTIECILKLM GFGIGNYFRD RWNMFDFIIV IGSIIDVVTT
1310 1320 1330 1340 1350
NVLPSASSFR TGSFRLFRAA RLVKLLRQGY TIRLLLWTFL QSFKALPYVC
1360 1370 1380 1390 1400
LLIAMLFFIY AIIGMQVFGN IRLDSKTSIN RHNNFRSFFY AVLLLFRCAT
1410 1420 1430 1440 1450
GESWQQIMLS CLSGRPCDPE SKMLDNSCGL DIAYIYFVTF IFLCSFLMLN
1460 1470 1480 1490 1500
LFVAVIMDNF DYLTRDTSIL GPHHLDEYSR VWAEYDPLAS GRVHYTDMYE
1510 1520 1530 1540 1550
MLRRMEPPVG FGRNCPYRLA CRKLIRMNMP LKEDGTVHFS TTLFALVRES
1560 1570 1580 1590 1600
LSIRMSSAEE MDKKDEEMRE VIKRVWPVQG KKIVDLLVPP NHELNNGKLT
1610 1620 1630 1640 1650
VGKVYGGLLI AENWRAYKAS QNQNNSLKTE KKEELFWEDD IKEYRDEEDY
1660 1670 1680 1690 1700
REYRDEEDYK DDYQEYQEYQ EDCKDYEEDY NQVETLEIES RNKYHSTPLH
1710 1720 1730 1740 1750
SPCIAINGQQ FQFQQLQYSD SEERPPSIFQ RIMGVMRTPS ARSSQGIDSE
1760 1770 1780 1790 1800
HSDNEMEGGH SIDKSHDKST WQRSFSFLRR GSSRRRKDST VQKSETASLQ
1810 1820 1830 1840 1850
PSEKQDFSWG LRPEHAAHPS APRPGSGSSR GLNFAQTVPL SPVSPRSPLP
1860 1870 1880 1890 1900
SQSPLGSPLA SPSMHRRSVS PRRGLDVGFA SAVSNIVDQA HSIAEHDRHR
1910 1920 1930 1940 1950
KHRAYFHPGK PDDSLSVPTS PQMRGRSRGR HRPPLQQQGQ VMGSPLPGPT
1960 1970 1980 1990 2000
SRRKEPTFYR STSLENRSRS PSPNLTPTST LHQHEYYGSA GLTDRSRSPS
2010 2020 2030 2040 2050
PTMTPPRKAT RKLPAVPSKP STLNLAQTRP RENMPRVMPS PTVPQPSKSP
2060 2070 2080 2090 2100
GSINFPRLNA SPTHIPRVGP TIGQAPPLGR LGRPEPYSPT ERNCISKLSP
2110 2120 2130 2140 2150
ERSRTLPIGQ RISNRDFSRG VDLYVSHRSR TFDPRINDRG RYFDDPSLDA
2160 2170 2180 2190
HMSDHRSETL PNGFKPKKRK PENLDMRGDG TGGPVRHESD EDDDWC
Length:2,196
Mass (Da):250,005
Last modified:May 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4A560CA12C9BB11
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86600 mRNA Translation: BAA13136.2

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5280

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86600 mRNA Translation: BAA13136.2
PIRiJC5280

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR002077, VDCCAlpha1
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 2 hits
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP91744_HETBL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P91744
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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