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Entry version 195 (07 Oct 2020)
Sequence version 1 (01 May 1997)
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Protein
Submitted name:

PI-3 kinase

Gene

Pi3K92E

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationImportedARBA annotation, Transferase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.1.137, 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-109704, PI3K Cascade
R-DME-110478, Insulin signaling pathway
R-DME-112399, IRS-mediated signalling
R-DME-114604, GPVI-mediated activation cascade
R-DME-1250342, PI3K events in ERBB4 signaling
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1433557, Signaling by SCF-KIT
R-DME-1660499, Synthesis of PIPs at the plasma membrane
R-DME-180292, GAB1 signalosome
R-DME-1963642, PI3K events in ERBB2 signaling
R-DME-198203, PI3K/AKT activation
R-DME-210993, Tie2 Signaling
R-DME-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-392451, G beta:gamma signalling through PI3Kgamma
R-DME-416476, G alpha (q) signalling events
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-5654689, PI-3K cascade:FGFR1
R-DME-5654695, PI-3K cascade:FGFR2
R-DME-5654710, PI-3K cascade:FGFR3
R-DME-5654720, PI-3K cascade:FGFR4
R-DME-5673001, RAF/MAP kinase cascade
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-912631, Regulation of signaling by CBL
R-DME-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PI-3 kinaseImported
Submitted name:
Phosphatidylinositol 3-kinase 92E, isoform AImported
Submitted name:
Phosphatidylinositol 3-kinase 92E, isoform BImported
Submitted name:
Phosphatidylinositol 3-kinase 92E, isoform CImported (EC:2.7.1.-Imported, EC:2.7.1.137Imported, EC:2.7.1.153Imported, EC:2.7.1.154Imported)
Submitted name:
Phosphoinositide 3-kinase, Dp110Imported
Submitted name:
SD05105pImported
Submitted name:
Uncharacterized protein Pi3K92EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pi3K92EImported
Synonyms:anon-92EdImported, Dmel\CG4141Imported, Dmp110Imported, DP110Imported, Dp110Imported, dP110Imported, dp110Imported, dp110alphaImported, dP13KImported, dPI3KImported, dPI3K[92E]Imported, Dpp110Imported, dpP110Imported, p110Imported, p120Imported, PI(3)KImported, PI-3 kinaseImported, PI-3-KImported, PI3'KImported, PI3KImported, PI3kImported, Pi3KImported, Pi3kImported, pi3kImported, PI3K-92DImported, PI3K-92EImported, PI3K-Dp110Imported, PI3K-dp110Imported, PI3K-IImported, Pi3K92DImported, PI3K92EImported, Pi3k92eImported, pi3k92EImported, pi3k92eImported, Pi3K92E|p110Imported, Pi3Kp110Imported, PI[[3]]KImported, PiK92EImported, reaImported, type-1 PI3KImported
ORF Names:CG4141Imported, Dmel_CG4141Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0015279, Pi3K92E

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0015279, Expressed in egg cell and 35 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-21625N

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083348

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P91634

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 129PI3K-ABDInterPro annotationAdd BLAST89
Domaini214 – 304PI3K-RBDInterPro annotationAdd BLAST91
Domaini344 – 522C2 PI3K-typeInterPro annotationAdd BLAST179
Domaini544 – 721PIK helicalInterPro annotationAdd BLAST178
Domaini816 – 1067PI3K/PI4KInterPro annotationAdd BLAST252

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0904, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171285

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002191_1_3_1

KEGG Orthology (KO)

More...
KOi
K00922

Identification of Orthologs from Complete Genome Data

More...
OMAi
LYTWTYA

Database of Orthologous Groups

More...
OrthoDBi
204282at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR003113, PI3K_adapt-bd_dom
IPR002420, PI3K_C2_dom
IPR000341, PI3K_Ras-bd_dom
IPR015433, PI_Kinase
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR10048, PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF02192, PI3K_p85B, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00142, PI3K_C2, 1 hit
SM00143, PI3K_p85B, 1 hit
SM00144, PI3K_rbd, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51544, PI3K_ABD, 1 hit
PS51547, PI3K_C2, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P91634-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNMMDNRALA YVAHQPKYET PPEEAEPPCM RFSVNLWKNE MLNWVDLICL
60 70 80 90 100
LPNGFLLELR VNPANTIQVI KVEMVNQAKQ MPLGYVIKEA CEYQVYGIST
110 120 130 140 150
FNIEPYTDET KRLSEVQPYF GILSLGERTD TTSFSSDYEL TKMVNGMIGT
160 170 180 190 200
TFDHNRTHGS PEIDDFRLYM TQTCDNIELE RSAYTWQQRL LYEHPLRLAN
210 220 230 240 250
STKMPELIRE RHPTRTFLIV VKNENDQSTF TLSVNEQDTP FSLTESTLQK
260 270 280 290 300
MNRSQMKMND RTSDYILKVS GRDEYLLGDY PLIQFLYIQE MLSDSAVPNV
310 320 330 340 350
VLQSVYRLES YINHHNEQAM VTKRPLPKKR TVHLHKSISS LWDMGNYFQL
360 370 380 390 400
TLHSISNVNF DKTRALKVGV HVCLYHGDKK LCAQRSTDSP NGNFDTFLFN
410 420 430 440 450
DLVMDFDIQM RNLPRMTRLC IVIFEVTKMS RSKKSSNNKD IALKDVPYNK
460 470 480 490 500
NPLAWVNTTI FDHKDILRTG RHTLYTWTYA DDIQSVEVFH PLGTIEPNPR
510 520 530 540 550
KEECALVDLT FLSSGTGTVR YPSEEVVLQY AADREQVNRL QRQLAGPEKP
560 570 580 590 600
IKELKELMAN YTGLDKIYEM VDQDRNAIWE RRNDILRELP EELSILLHCV
610 620 630 640 650
YWKERDDVAD MWYLLKQWPL ISIERSLELL DYAYPDPAVR RFAIRCLHFL
660 670 680 690 700
KDEDLLLYLL QLVQAIKHES YLESDLVVFL LERALRNQRI GHYFFWHLRS
710 720 730 740 750
EMQTPSMQTR FGLLLEVYLK GCKHHVAPLR KQLHVLEKLK QGSLIAKKGS
760 770 780 790 800
KEKVKTMLQD FLRDQRNSAV FQNIQNPLNP SFRCSGVTPD RCKVMDSKMR
810 820 830 840 850
PLWVVFENAD VNASDVHIIF KNGDDLRQDM LTLQMLRVMD QLWKRDGMDF
860 870 880 890 900
RMNIYNCISM EKSLGMIEVV RHAETIANIQ KEKGMFSATS PFKKGSLLSW
910 920 930 940 950
LKEHNKPADK LNKAINEFTL SCAGYCVATY VLGVADRHSD NIMVKRNGQL
960 970 980 990 1000
FHIDFGHILG HFKEKLGVRR ERVPFVLTHD FVYVINKGFN DRESKEFCHF
1010 1020 1030 1040 1050
QELCERAFLV LRKHGCLILS LFSMMISTGL PELSSEKDLD YLRETLVLDY
1060 1070 1080
TEEKAREHFR AKFSEALANS WKTSLNWASH NFSKNNKQ
Length:1,088
Mass (Da):127,006
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABDEF07902AAB81C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55792.1
AE014297 Genomic DNA Translation: AAN14359.1
BT003173 mRNA Translation: AAO24928.1
DQ792599 Genomic DNA Translation: ABG88073.1
DQ792600 Genomic DNA Translation: ABG88075.1
AE014297 Genomic DNA Translation: AGB96150.1
Y09070 mRNA Translation: CAA70291.1
FR870118 Genomic DNA Translation: CCB63076.1
FR870119 Genomic DNA Translation: CCB63077.1
FR870121 Genomic DNA Translation: CCB63079.1
FR870122 Genomic DNA Translation: CCB63080.1
FR870124 Genomic DNA Translation: CCB63082.1
FR870125 Genomic DNA Translation: CCB63083.1
FR870126 Genomic DNA Translation: CCB63084.1
FR870127 Genomic DNA Translation: CCB63085.1
FR870128 Genomic DNA Translation: CCB63086.1

Protein sequence database of the Protein Information Resource

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PIRi
T13950

NCBI Reference Sequences

More...
RefSeqi
NP_001262770.1, NM_001275841.1
NP_650902.1, NM_142645.3
NP_732536.1, NM_169910.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0083940; FBpp0083348; FBgn0015279
FBtr0083941; FBpp0083349; FBgn0015279
FBtr0334643; FBpp0306705; FBgn0015279

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
42446

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4141

UCSC genome browser

More...
UCSCi
CG4141-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014297 Genomic DNA Translation: AAF55792.1
AE014297 Genomic DNA Translation: AAN14359.1
BT003173 mRNA Translation: AAO24928.1
DQ792599 Genomic DNA Translation: ABG88073.1
DQ792600 Genomic DNA Translation: ABG88075.1
AE014297 Genomic DNA Translation: AGB96150.1
Y09070 mRNA Translation: CAA70291.1
FR870118 Genomic DNA Translation: CCB63076.1
FR870119 Genomic DNA Translation: CCB63077.1
FR870121 Genomic DNA Translation: CCB63079.1
FR870122 Genomic DNA Translation: CCB63080.1
FR870124 Genomic DNA Translation: CCB63082.1
FR870125 Genomic DNA Translation: CCB63083.1
FR870126 Genomic DNA Translation: CCB63084.1
FR870127 Genomic DNA Translation: CCB63085.1
FR870128 Genomic DNA Translation: CCB63086.1
PIRiT13950
RefSeqiNP_001262770.1, NM_001275841.1
NP_650902.1, NM_142645.3
NP_732536.1, NM_169910.2

3D structure databases

SMRiP91634
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-21625N
STRINGi7227.FBpp0083348

Genome annotation databases

EnsemblMetazoaiFBtr0083940; FBpp0083348; FBgn0015279
FBtr0083941; FBpp0083349; FBgn0015279
FBtr0334643; FBpp0306705; FBgn0015279
GeneIDi42446
KEGGidme:Dmel_CG4141
UCSCiCG4141-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
42446
FlyBaseiFBgn0015279, Pi3K92E

Phylogenomic databases

eggNOGiKOG0904, Eukaryota
GeneTreeiENSGT00940000171285
HOGENOMiCLU_002191_1_3_1
KOiK00922
OMAiLYTWTYA
OrthoDBi204282at2759

Enzyme and pathway databases

BRENDAi2.7.1.137, 1994
ReactomeiR-DME-109704, PI3K Cascade
R-DME-110478, Insulin signaling pathway
R-DME-112399, IRS-mediated signalling
R-DME-114604, GPVI-mediated activation cascade
R-DME-1250342, PI3K events in ERBB4 signaling
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1433557, Signaling by SCF-KIT
R-DME-1660499, Synthesis of PIPs at the plasma membrane
R-DME-180292, GAB1 signalosome
R-DME-1963642, PI3K events in ERBB2 signaling
R-DME-198203, PI3K/AKT activation
R-DME-210993, Tie2 Signaling
R-DME-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-392451, G beta:gamma signalling through PI3Kgamma
R-DME-416476, G alpha (q) signalling events
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-5654689, PI-3K cascade:FGFR1
R-DME-5654695, PI-3K cascade:FGFR2
R-DME-5654710, PI-3K cascade:FGFR3
R-DME-5654720, PI-3K cascade:FGFR4
R-DME-5673001, RAF/MAP kinase cascade
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-912631, Regulation of signaling by CBL
R-DME-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
42446, 1 hit in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pi3K68D, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
42446

Gene expression databases

BgeeiFBgn0015279, Expressed in egg cell and 35 other tissues

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR035892, C2_domain_sf
IPR011009, Kinase-like_dom_sf
IPR000403, PI3/4_kinase_cat_dom
IPR036940, PI3/4_kinase_cat_sf
IPR018936, PI3/4_kinase_CS
IPR001263, PI3K_accessory_dom
IPR042236, PI3K_accessory_sf
IPR003113, PI3K_adapt-bd_dom
IPR002420, PI3K_C2_dom
IPR000341, PI3K_Ras-bd_dom
IPR015433, PI_Kinase
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR10048, PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454, PI3_PI4_kinase, 1 hit
PF00792, PI3K_C2, 1 hit
PF02192, PI3K_p85B, 1 hit
PF00794, PI3K_rbd, 1 hit
PF00613, PI3Ka, 1 hit
SMARTiView protein in SMART
SM00142, PI3K_C2, 1 hit
SM00143, PI3K_p85B, 1 hit
SM00144, PI3K_rbd, 1 hit
SM00145, PI3Ka, 1 hit
SM00146, PI3Kc, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
SSF54236, SSF54236, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915, PI3_4_KINASE_1, 1 hit
PS00916, PI3_4_KINASE_2, 1 hit
PS50290, PI3_4_KINASE_3, 1 hit
PS51544, PI3K_ABD, 1 hit
PS51547, PI3K_C2, 1 hit
PS51546, PI3K_RBD, 1 hit
PS51545, PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP91634_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P91634
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: October 7, 2020
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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