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Entry version 60 (29 Sep 2021)
Sequence version 1 (01 May 1997)
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Protein

Larval cuticle protein 1

Gene

Lcp1

Organism
Drosophila miranda (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the larval cuticle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Larval cuticle protein 1
Alternative name(s):
Larval cuticle protein I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lcp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila miranda (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7229 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0013843, Dmir\Lcp1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cuticle

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 161 PublicationAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000638817 – 138Larval cuticle protein 1Add BLAST122

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 110Chitin-binding type R&RPROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Signal

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
HGNIQGK

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031311, CHIT_BIND_RR_consensus
IPR000618, Insect_cuticle

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00379, Chitin_bind_4, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00233, CHIT_BIND_RR_1, 1 hit
PS51155, CHIT_BIND_RR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P91627-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKFVMVFAV LGVAAAGVAH VPHPQVSHPV GRSEDVHAEV KSEHSDVRAD
60 70 80 90 100
GFDADLLVSN SIQQASSGDV HGNIHGSFSW ISPEGEHVEI KYVADENGYQ
110 120 130
PVGAVLPTPP PIPEAIARAV AWLEAHPQAP EPVHHSHH
Length:138
Mass (Da):14,746
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2641B0F51B05D2D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti13V → L in strain: 0101.3, 0101.4, 0101.5, 0101.7, 0101.9, MSH22, MA28, MA32, MSH38, SP138, SP235 and SP295. 1
Natural varianti29P → Q in strain: 0101.3, 0101.4, 0101.5, 0101.7, 0101.9, MSH22, MA28, MA32, MSH38, SP138, SP235 and SP295. 1
Natural varianti47V → I in strain: 0101.3, 0101.4, 0101.5, 0101.7, 0101.9, MSH22, MA28, MA32, MSH38, SP138, SP235 and SP295. 1
Natural varianti52F → Y in strain: SP235. 1
Natural varianti53D → H in strain: 0101.5. 1
Natural varianti56L → F in strain: MSH22. 1
Natural varianti129A → V in strain: 0101.3, 0101.4, 0101.5, 0101.7, 0101.9, MSH22, MA28, MA32, MSH38, SP138, SP235 and SP295. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X97809 Genomic DNA Translation: CAA66390.1
AF219246 Genomic DNA Translation: AAF74425.1
AF219247 Genomic DNA Translation: AAF74426.1
AF219253 Genomic DNA Translation: AAF74432.1
AF219254 Genomic DNA Translation: AAF74433.1
AF219255 Genomic DNA Translation: AAF74434.1
AF219256 Genomic DNA Translation: AAF74435.1
DQ867949 Genomic DNA Translation: ABJ74489.1
DQ867950 Genomic DNA Translation: ABJ74490.1
DQ867951 Genomic DNA Translation: ABJ74491.1
DQ867952 Genomic DNA Translation: ABJ74492.1
DQ867953 Genomic DNA Translation: ABJ74493.1
DQ867954 Genomic DNA Translation: ABJ74494.1
DQ867955 Genomic DNA Translation: ABJ74495.1
DQ867956 Genomic DNA Translation: ABJ74496.1
DQ867957 Genomic DNA Translation: ABJ74497.1
DQ867958 Genomic DNA Translation: ABJ74498.1
DQ867959 Genomic DNA Translation: ABJ74499.1
DQ867960 Genomic DNA Translation: ABJ74500.1
DQ867961 Genomic DNA Translation: ABJ74501.1
DQ867962 Genomic DNA Translation: ABJ74502.1
DQ867963 Genomic DNA Translation: ABJ74503.1
DQ867964 Genomic DNA Translation: ABJ74504.1
DQ867965 Genomic DNA Translation: ABJ74505.1
DQ867966 Genomic DNA Translation: ABJ74506.1
DQ867967 Genomic DNA Translation: ABJ74507.1
DQ867968 Genomic DNA Translation: ABJ74508.1
DQ867969 Genomic DNA Translation: ABJ74509.1
DQ867970 Genomic DNA Translation: ABJ74510.1
DQ867971 Genomic DNA Translation: ABJ74511.1
DQ867972 Genomic DNA Translation: ABJ74512.1

NCBI Reference Sequences

More...
RefSeqi
XP_017150715.1, XM_017295226.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
108160938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dmn:108160938

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97809 Genomic DNA Translation: CAA66390.1
AF219246 Genomic DNA Translation: AAF74425.1
AF219247 Genomic DNA Translation: AAF74426.1
AF219253 Genomic DNA Translation: AAF74432.1
AF219254 Genomic DNA Translation: AAF74433.1
AF219255 Genomic DNA Translation: AAF74434.1
AF219256 Genomic DNA Translation: AAF74435.1
DQ867949 Genomic DNA Translation: ABJ74489.1
DQ867950 Genomic DNA Translation: ABJ74490.1
DQ867951 Genomic DNA Translation: ABJ74491.1
DQ867952 Genomic DNA Translation: ABJ74492.1
DQ867953 Genomic DNA Translation: ABJ74493.1
DQ867954 Genomic DNA Translation: ABJ74494.1
DQ867955 Genomic DNA Translation: ABJ74495.1
DQ867956 Genomic DNA Translation: ABJ74496.1
DQ867957 Genomic DNA Translation: ABJ74497.1
DQ867958 Genomic DNA Translation: ABJ74498.1
DQ867959 Genomic DNA Translation: ABJ74499.1
DQ867960 Genomic DNA Translation: ABJ74500.1
DQ867961 Genomic DNA Translation: ABJ74501.1
DQ867962 Genomic DNA Translation: ABJ74502.1
DQ867963 Genomic DNA Translation: ABJ74503.1
DQ867964 Genomic DNA Translation: ABJ74504.1
DQ867965 Genomic DNA Translation: ABJ74505.1
DQ867966 Genomic DNA Translation: ABJ74506.1
DQ867967 Genomic DNA Translation: ABJ74507.1
DQ867968 Genomic DNA Translation: ABJ74508.1
DQ867969 Genomic DNA Translation: ABJ74509.1
DQ867970 Genomic DNA Translation: ABJ74510.1
DQ867971 Genomic DNA Translation: ABJ74511.1
DQ867972 Genomic DNA Translation: ABJ74512.1
RefSeqiXP_017150715.1, XM_017295226.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi108160938
KEGGidmn:108160938

Organism-specific databases

FlyBaseiFBgn0013843, Dmir\Lcp1

Phylogenomic databases

OMAiHGNIQGK

Family and domain databases

InterProiView protein in InterPro
IPR031311, CHIT_BIND_RR_consensus
IPR000618, Insect_cuticle
PfamiView protein in Pfam
PF00379, Chitin_bind_4, 1 hit
PROSITEiView protein in PROSITE
PS00233, CHIT_BIND_RR_1, 1 hit
PS51155, CHIT_BIND_RR_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCP1_DROMI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P91627
Secondary accession number(s): A1BWX7
, A1BWX9, A1BWY7, A1BWY9, A1BWZ7, P91628, Q9NCK7, Q9NCK8, Q9NCK9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 29, 2021
This is version 60 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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