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Entry version 125 (11 Dec 2019)
Sequence version 1 (01 May 1997)
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Protein
Submitted name:

Nuclear Pore complex Protein

Gene

npp-12

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-159227 Transport of the SLBP independent Mature mRNA
R-CEL-159230 Transport of the SLBP Dependant Mature mRNA
R-CEL-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins
R-CEL-3232142 SUMOylation of ubiquitinylation proteins
R-CEL-3301854 Nuclear Pore Complex (NPC) Disassembly
R-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-4085377 SUMOylation of SUMOylation proteins
R-CEL-4551638 SUMOylation of chromatin organization proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear Pore complex ProteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:npp-12Imported
ORF Names:CELE_T23H2.1Imported, T23H2.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
T23H2.1 ; CE14106 ; WBGene00003798 ; npp-12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1753 – 1771HelicalSequence analysisAdd BLAST19

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500416191419 – 1847Sequence analysisAdd BLAST1829

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P91495

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P91495

PeptideAtlas

More...
PeptideAtlasi
P91495

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003798 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T23H2.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini436 – 513BIG2InterPro annotationAdd BLAST78
Domaini744 – 819BIG2InterPro annotationAdd BLAST76

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1833 Eukaryota
ENOG410XNNU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019782

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P91495

KEGG Orthology (KO)

More...
KOi
K14314

Identification of Orthologs from Complete Genome Data

More...
OMAi
DIICFDS

Database of Orthologous Groups

More...
OrthoDBi
843414at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P91495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003343 Big_2
IPR008964 Invasin/intimin_cell_adhesion

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02368 Big_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00635 BID_2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49373 SSF49373, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P91495-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIILRSLLVL ALVQITISYR LNVPRVLLPY HPTVPVSFVL EVTHPTGGCF
60 70 80 90 100
TWRSTRPDIV SVKRIETNEA GCSDKAEIRS VAKPGTVGSS ELSAVIFAED
110 120 130 140 150
KGSGTTLSCG VTVDEIATIS IETTTKVLFV DAAPARMTVD AFNADGDRFS
160 170 180 190 200
TLSEIALEWE LASTSSNKAK PLRIVPFEQS TYEAPSEIVK LEKNRKKGYL
210 220 230 240 250
ILIEGVGTGT ATLTTKFSDA YLQKVAAHNV ELAVVANLLL VPSQDVYLPV
260 270 280 290 300
HSVLPFQVLI VKQRGTEIVN MPNPSYELQI DGGDVASLDK KSSSVRALTI
310 320 330 340 350
GNTAVHLLSS HVDVRAKAGL RPPSTVIHVV DAESVQWHVS GDNWMLETGK
360 370 380 390 400
QYTINVELLD EHGNVMFVAD NSRFDTHIDE QFLHVDFKSE NGTWFLVTPL
410 420 430 440 450
KPSKTTLRTK FVAIIDAKGN RIAQSGKIGG EQRVTIVDPV RIVPPVIYLP
460 470 480 490 500
FVSEKRSQID LTATGGSGLF EWTSEDGHVA TVDLLTGRMT ANSLGSTKVK
510 520 530 540 550
ATDKRNDQLR DIASVHILEV SGIGFGETVR ETFVGDTLTL NIKATGLTSD
560 570 580 590 600
GLLVEMSDCR NIRAHVQITD NALLRHESSA DSSLPMMGTG CGTITFKGLS
610 620 630 640 650
SGDARVSISY LGHKASIDVA VYEKLSISEE SSSIALGSTH PLTVSGGPRP
660 670 680 690 700
WILDPANFYK TQETKQSQLQ VTFENEKVLF KCGSSEVTEA VRLRIGNLKS
710 720 730 740 750
STLPLPIHSE ITVSICCAKP TRLEIFDKKQ RPSKCPLNVH SMLINTNVEL
760 770 780 790 800
VLRGSGVCNG AATPLASING LSPKWTTSDS GLLTVNRHGI EADATSGKKE
810 820 830 840 850
GQVTIQAQAG SLSTKYEITV KKGLNVEPAR LVLWNEAVSK GTFTITGGSG
860 870 880 890 900
HFHVDNLPTS DSPVAIALRA RSLTVTPKNN GQVNLRISDA CLVGQHADAS
910 920 930 940 950
VRIADIHSLA IDAPQFVEIG QEVEVEILAQ DETGASFEKE HRPLADAQLD
960 970 980 990 1000
ASNNHVILTK VDGLRYTLRA NSIGTVSLSA SSKSSSGRVL SSRPHTVQIF
1010 1020 1030 1040 1050
SPIFLQPKRL TLIPDSKFQL EVVGGPQPTP PLDFSLNNSM IASIEPNALI
1060 1070 1080 1090 1100
TSSELGYTAI TGTVRVGDGH VTLDTVVLRV ASLGGIILSA SSRKVETGGR
1110 1120 1130 1140 1150
VNLRLRGVIA GAEDEEPFAF GGAIYPFKVT WSVSDPSVLF TTHPLGGDVV
1160 1170 1180 1190 1200
EPTDNQFAIW FNAIRGGSVT VKAVVELNEK ARKHFTGRTS TFTAETTITV
1210 1220 1230 1240 1250
EDGLSLVQPE MDINTVRVAP NSQLKMVTAW SQASFSVPSD FSSRIVISAD
1260 1270 1280 1290 1300
GHLITNGKEG SAAITVRNVN SPDNETVLIP VTVSRVASLD VHPTIELKSA
1310 1320 1330 1340 1350
FENSPLIHLP VGAQIQLNVV PRDARGRRLA AASNSINFRP HRFDLTDIVA
1360 1370 1380 1390 1400
TNSNQTLTIT LKTAGDTVLR IGDASNTHIA TFIRLSASES ILPRAAHKYA
1410 1420 1430 1440 1450
NDLVVSDVIC LQSNIFTVDG SRWSSQSSSE GRISWLDENL GVAQLTKAGN
1460 1470 1480 1490 1500
TFIRLHADKQ TIHSKISVVL PSSLRFPDGQ KPEFVSNDEH SVFVIPVIAA
1510 1520 1530 1540 1550
TNNTSGSKVS SIYGECTADQ IRSFDAIGAP FECQVAFTRR SKIISAVNWL
1560 1570 1580 1590 1600
TVSAVFSPVF GYGCEIRRFD SSVSTSSIVV PEELLKDQFD ARITAKWISD
1610 1620 1630 1640 1650
GTVQVNDATI DVPFHFAFIV EEKELVFSNM NQIEAALSIW APTYDSKHIV
1660 1670 1680 1690 1700
VSGCEGDIVS VEKTSRSSDK HSAKANVFYN IRLNIKSAAL FTEHAKKCQI
1710 1720 1730 1740 1750
SVENTLTGQV IRVPVTVQLL DETAKQVYNA LESRGVVDVL LILAHKYSHA
1760 1770 1780 1790 1800
IPTLLWTCLV GIIILVIGIY VKMNVFDKTG SFGDNTLNNT THQTSMASSL
1810 1820 1830 1840
SSTNVSLREP VFRSTPIAGS PQVSLPTARD RLRNQMGSGG DNRLWSY
Length:1,847
Mass (Da):199,639
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1A5BDAD1261D549A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD70770.1

Protein sequence database of the Protein Information Resource

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PIRi
T28969

NCBI Reference Sequences

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RefSeqi
NP_491855.1, NM_059454.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T23H2.1.1; T23H2.1.1; WBGene00003798

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172348

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_T23H2.1

UCSC genome browser

More...
UCSCi
T23H2.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CCD70770.1
PIRiT28969
RefSeqiNP_491855.1, NM_059454.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.T23H2.1

Proteomic databases

EPDiP91495
PaxDbiP91495
PeptideAtlasiP91495

Genome annotation databases

EnsemblMetazoaiT23H2.1.1; T23H2.1.1; WBGene00003798
GeneIDi172348
KEGGicel:CELE_T23H2.1
UCSCiT23H2.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172348
WormBaseiT23H2.1 ; CE14106 ; WBGene00003798 ; npp-12

Phylogenomic databases

eggNOGiKOG1833 Eukaryota
ENOG410XNNU LUCA
GeneTreeiENSGT00390000009491
HOGENOMiHOG000019782
InParanoidiP91495
KOiK14314
OMAiDIICFDS
OrthoDBi843414at2759
PhylomeDBiP91495

Enzyme and pathway databases

ReactomeiR-CEL-159227 Transport of the SLBP independent Mature mRNA
R-CEL-159230 Transport of the SLBP Dependant Mature mRNA
R-CEL-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-3108214 SUMOylation of DNA damage response and repair proteins
R-CEL-3232142 SUMOylation of ubiquitinylation proteins
R-CEL-3301854 Nuclear Pore Complex (NPC) Disassembly
R-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-4085377 SUMOylation of SUMOylation proteins
R-CEL-4551638 SUMOylation of chromatin organization proteins

Gene expression databases

BgeeiWBGene00003798 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR003343 Big_2
IPR008964 Invasin/intimin_cell_adhesion
PfamiView protein in Pfam
PF02368 Big_2, 1 hit
SMARTiView protein in SMART
SM00635 BID_2, 2 hits
SUPFAMiSSF49373 SSF49373, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP91495_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P91495
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: December 11, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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