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Protein

Proteasome subunit beta type-2

Gene

pbs-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.984

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-2 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit beta 4
Gene namesi
Name:pbs-4
ORF Names:T20F5.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT20F5.2 ; CE13818 ; WBGene00003950 ; pbs-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480461 – 199Proteasome subunit beta type-2Add BLAST199

Proteomic databases

EPDiP91477
PaxDbiP91477
PeptideAtlasiP91477
PRIDEiP91477

Expressioni

Gene expression databases

BgeeiWBGene00003950

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi6239.T20F5.2.1

Structurei

3D structure databases

ProteinModelPortaliP91477
SMRiP91477
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0177 Eukaryota
COG0638 LUCA
HOGENOMiHOG000188743
InParanoidiP91477
KOiK02734
OrthoDBiEOG091G0K9M
PhylomeDBiP91477

Family and domain databases

CDDicd03758 proteasome_beta_type_2, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR035206 Proteasome_beta2
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF6 PTHR11599:SF6, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P91477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHFLVGISTE NYVILAADKA TFAYGAILAD SENDKEYRLG KKLTMMCIGE
60 70 80 90 100
EGDVAQFGDW TKRNLQLYSV RNGYEVSPSC AHHFVRRSIA EGLRSQDHYT
110 120 130 140 150
VDVLIGGYDD KEDKAFLGSV DYLANGLGQQ PYLFRGFCGR FCYAIMDREY
160 170 180 190
KKDMTEAEGL ALMNKCIGEA KRRFVANIPG YKVVIIDKKG YRKLDDVLF
Length:199
Mass (Da):22,549
Last modified:October 18, 2001 - v2
Checksum:i27510AF7CBA8DEBF
GO

Sequence cautioni

The sequence CCD67779 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080916 Genomic DNA Translation: CCD67779.1 Different initiation.
PIRiT29206
RefSeqiNP_491261.1, NM_058860.6
UniGeneiCel.20577

Genome annotation databases

GeneIDi171975
KEGGicel:CELE_T20F5.2
UCSCiT20F5.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSB2_CAEEL
AccessioniPrimary (citable) accession number: P91477
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 18, 2001
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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