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Entry version 125 (11 Dec 2019)
Sequence version 2 (01 Oct 2001)
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Protein

Spindle-defective protein 5

Gene

spd-5

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spindle-defective protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:spd-5
ORF Names:F56A3.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F56A3.4 ; CE28834 ; WBGene00004955 ; spd-5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi592R → K in OR213ts; induces defective centrosomes at restrictive temperature when homozygous. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000721131 – 1198Spindle-defective protein 5Add BLAST1198

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P91349

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P91349

PeptideAtlas

More...
PeptideAtlasi
P91349

PRoteomics IDEntifications database

More...
PRIDEi
P91349

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P91349

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryogenesis and during postembryonic meiotic divisions that produce sperm in males.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004955 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
37615, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1357 RSA centrosome-targeting complex

Database of interacting proteins

More...
DIPi
DIP-24727N

Protein interaction database and analysis system

More...
IntActi
P91349, 10 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F56A3.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P91349

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili67 – 381Sequence analysisAdd BLAST315
Coiled coili566 – 603Sequence analysisAdd BLAST38
Coiled coili694 – 916Sequence analysisAdd BLAST223
Coiled coili983 – 1035Sequence analysisAdd BLAST53
Coiled coili1127 – 1175Sequence analysisAdd BLAST49

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410K7VK Eukaryota
ENOG4110M0Z LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P91349

Identification of Orthologs from Complete Genome Data

More...
OMAi
CDEICRR

Database of Orthologous Groups

More...
OrthoDBi
421255at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P91349

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P91349-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDNSVLNED SNLEHVEGQP RRSMSQPVLN VEGDKRTSST SATQQQVLSG
60 70 80 90 100
AFSSADVRSI PIIQTWEENK ALKTKITILR GELQMYQRRY SEAKEASQKR
110 120 130 140 150
VKEVMDDYVD LKLGQENVQE KMEQYKLMEE DLLAMQSRIE TSEDNFARQM
160 170 180 190 200
KEFEAQKHAM EERIKELELS ATDANNTTVG SFRGTLDDIL KKNDPDFTLT
210 220 230 240 250
SGYEERKIND LEAKLLSEID KVAELEDHIQ QLRQELDDQS ARLADSENVR
260 270 280 290 300
AQLEAATGQG ILGAAGNAMV PNSTFMIGNG RESQTRDQLN YIDDLETKLA
310 320 330 340 350
DAKKENDKAR QALVEYMNKC SKLEHEIRTM VKNSTFDSSS MLLGGQTSDE
360 370 380 390 400
LKIQIGKVNG ELNVLRAENR ELRIRCDQLT GGDGNLSISL GQSRLMAGIA
410 420 430 440 450
TNDVDSIGQG NETGGTSMRI LPRESQLDDL EESKLPLMDT SSAVRNQQQF
460 470 480 490 500
ASMWEDFESV KDSLQNNHND TLEGSFNSSM PPPGRDATQS FLSQKSFKNS
510 520 530 540 550
PIVMQKPKSL HLHLKSHQSE GAGEQIQNNS FSTKTASPHV SQSHIPILHD
560 570 580 590 600
MQQILDSSAM FLEGQHDVAV NVEQMQEKMS QIREALARLF ERLKSSAALF
610 620 630 640 650
EEILERMGSS DPNADKIKKM KLAFETSIND KLNVSAILEA AEKDLHNMSL
660 670 680 690 700
NFSILEKSIV SQAAEASRRF TIAPDAEDVA SSSLLNASYS PLFKFTSNSD
710 720 730 740 750
IVEKLQNEVS ELKNELEMAR TRDMRSPLNG SSGRLSDVQI NTNRMFEDLE
760 770 780 790 800
VSEATLQKAK EENSTLKSQF AELEANLHQV NSKLGEVRCE LNEALARVDG
810 820 830 840 850
EQETRVKAEN ALEEARQLIS SLKHEENELK KTITDMGMRL NEAKKSDEFL
860 870 880 890 900
KSELSTALEE EKKSQNLADE LSEELNGWRM RTKEAENKVE HASSEKSEML
910 920 930 940 950
ERIVHLETEM EKLSTSEIAA DYCSTKMTER KKEIELAKYR EDFENAAIVG
960 970 980 990 1000
LERISKEISE LTKKTLKAKI IPSNISSIQL VCDELCRRLS REREQQHEYA
1010 1020 1030 1040 1050
KVMRDVNEKI EKLQLEKDAL EHELKMMSSN NENVPPVGTS VSGMPTKTSN
1060 1070 1080 1090 1100
QKCAQPHYTS PTRQLLHEST MAVDAIVQKL KKTHNMSGMG PELKETIGNV
1110 1120 1130 1140 1150
INESRVLRDF LHQKLILFKG IDMSNWKNET VDQLITDLGQ LHQDNLMLEE
1160 1170 1180 1190
QIKKYKKELK LTKSAIPTLG VEFQDRIKTE IGKIATDMGG AVKEIRKK
Length:1,198
Mass (Da):135,148
Last modified:October 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFDFE3AAB765EA2B9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080752 Genomic DNA Translation: CCD66432.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T29145

NCBI Reference Sequences

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RefSeqi
NP_491539.1, NM_059138.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F56A3.4.1; F56A3.4.1; WBGene00004955
F56A3.4.2; F56A3.4.2; WBGene00004955

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F56A3.4

UCSC genome browser

More...
UCSCi
F56A3.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080752 Genomic DNA Translation: CCD66432.1
PIRiT29145
RefSeqiNP_491539.1, NM_059138.4

3D structure databases

SMRiP91349
ModBaseiSearch...

Protein-protein interaction databases

BioGridi37615, 9 interactors
ComplexPortaliCPX-1357 RSA centrosome-targeting complex
DIPiDIP-24727N
IntActiP91349, 10 interactors
STRINGi6239.F56A3.4

PTM databases

iPTMnetiP91349

Proteomic databases

EPDiP91349
PaxDbiP91349
PeptideAtlasiP91349
PRIDEiP91349

Genome annotation databases

EnsemblMetazoaiF56A3.4.1; F56A3.4.1; WBGene00004955
F56A3.4.2; F56A3.4.2; WBGene00004955
GeneIDi172155
KEGGicel:CELE_F56A3.4
UCSCiF56A3.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172155
WormBaseiF56A3.4 ; CE28834 ; WBGene00004955 ; spd-5

Phylogenomic databases

eggNOGiENOG410K7VK Eukaryota
ENOG4110M0Z LUCA
InParanoidiP91349
OMAiCDEICRR
OrthoDBi421255at2759
PhylomeDBiP91349

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P91349

Gene expression databases

BgeeiWBGene00004955 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPD5_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P91349
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2001
Last modified: December 11, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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