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Protein

Probable glutathione S-transferase 6

Gene

gst-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8GlutathioneBy similarity1
Binding sitei39GlutathioneBy similarity1
Binding sitei43GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation
R-CEL-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase 6 (EC:2.5.1.18)
Alternative name(s):
GST class-sigma
Gene namesi
Name:gst-6
ORF Names:F11G11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF11G11.3 ; CE32622 ; WBGene00001754 ; gst-6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001859291 – 206Probable glutathione S-transferase 6Add BLAST206

Proteomic databases

EPDiP91252
PaxDbiP91252
PeptideAtlasiP91252
PRIDEiP91252

Expressioni

Gene expression databases

BgeeiWBGene00001754 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

STRINGi6239.F11G11.3

Structurei

3D structure databases

ProteinModelPortaliP91252
SMRiP91252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 79GST N-terminalAdd BLAST78
Domaini81 – 206GST C-terminalAdd BLAST126

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 51Glutathione bindingBy similarity3
Regioni63 – 64Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Sigma family.Curated

Phylogenomic databases

eggNOGiENOG410IN5B Eukaryota
ENOG4112BRZ LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
InParanoidiP91252
KOiK00799
OMAiLLISQHV
OrthoDBiEOG091G0MBB
PhylomeDBiP91252

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P91252-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVHYKLVYFP LRARAEIARQ IFAYAGQDYS EENLSFEQWP ARKNNTPFGQ
60 70 80 90 100
LPILEVDGKP LGQSYAIARY LAREFGIAGQ NDTEAAEVDA IADQFKDYLN
110 120 130 140 150
DVSPYLTVLA GFKPGDKDQL RTDVFVPAFK KNFEFFENIL ASNHSGFFVG
160 170 180 190 200
NSLTWVDLLI SQHVQDILDK DLAVVEEFKK VLAHRKKVQS IDRIQKYIAN

RPDYPF
Length:206
Mass (Da):23,617
Last modified:March 1, 2003 - v2
Checksum:i347CF944862A1571
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA Translation: CCD69256.1
PIRiT29984
RefSeqiNP_494882.2, NM_062481.7
UniGeneiCel.14875

Genome annotation databases

EnsemblMetazoaiF11G11.3; F11G11.3; WBGene00001754
GeneIDi173841
KEGGicel:CELE_F11G11.3
UCSCiF11G11.3 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081119 Genomic DNA Translation: CCD69256.1
PIRiT29984
RefSeqiNP_494882.2, NM_062481.7
UniGeneiCel.14875

3D structure databases

ProteinModelPortaliP91252
SMRiP91252
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F11G11.3

Proteomic databases

EPDiP91252
PaxDbiP91252
PeptideAtlasiP91252
PRIDEiP91252

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF11G11.3; F11G11.3; WBGene00001754
GeneIDi173841
KEGGicel:CELE_F11G11.3
UCSCiF11G11.3 c. elegans

Organism-specific databases

CTDi173841
WormBaseiF11G11.3 ; CE32622 ; WBGene00001754 ; gst-6

Phylogenomic databases

eggNOGiENOG410IN5B Eukaryota
ENOG4112BRZ LUCA
GeneTreeiENSGT00670000097856
HOGENOMiHOG000115733
InParanoidiP91252
KOiK00799
OMAiLLISQHV
OrthoDBiEOG091G0MBB
PhylomeDBiP91252

Enzyme and pathway databases

ReactomeiR-CEL-156590 Glutathione conjugation
R-CEL-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Miscellaneous databases

PROiPR:P91252

Gene expression databases

BgeeiWBGene00001754 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGST6_CAEEL
AccessioniPrimary (citable) accession number: P91252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: September 12, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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