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Entry version 142 (18 Sep 2019)
Sequence version 2 (01 Jan 1998)
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Protein

Leucine-rich repeat-containing protein egg-6

Gene

egg-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for apical extracellular matrix organization and epithelial junction maintenance.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein egg-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:egg-6Imported
ORF Names:K07A12.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
K07A12.2 ; CE11866 ; WBGene00010621 ; egg-6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 854ExtracellularSequence analysisAdd BLAST836
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei855 – 875HelicalSequence analysisAdd BLAST21
Topological domaini876 – 961CytoplasmicSequence analysisAdd BLAST86

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Lethal at early L1 larval stage due to excretory defects. Maternal copy required for survival.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042239419 – 961Leucine-rich repeat-containing protein egg-6Sequence analysisAdd BLAST943

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P90920

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P90920

PeptideAtlas

More...
PeptideAtlasi
P90920

PRoteomics IDEntifications database

More...
PRIDEi
P90920

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In L1 larvae, expressed in a subset of epithelial cells including epidermal, vulval and rectal cells and the excretory duct and pore. Also detected in some neurons. Absent from internal epithelia such as the gut and pharyngeal tubes.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression begins around the ventral closure stage of embryogenesis, continues throughout larval development and decreases in adulthood.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00010621 Expressed in 5 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
38103, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-24762N

STRING: functional protein association networks

More...
STRINGi
6239.K07A12.2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati60 – 78LRR 1Sequence analysisAdd BLAST19
Repeati79 – 101LRR 2Sequence analysisAdd BLAST23
Repeati103 – 124LRR 3Sequence analysisAdd BLAST22
Repeati125 – 148LRR 4Sequence analysisAdd BLAST24
Repeati150 – 172LRR 5Sequence analysisAdd BLAST23
Repeati174 – 197LRR 6Sequence analysisAdd BLAST24
Repeati199 – 222LRR 7Sequence analysisAdd BLAST24
Repeati223 – 245LRR 8Sequence analysisAdd BLAST23
Repeati247 – 269LRR 9Sequence analysisAdd BLAST23
Repeati270 – 294LRR 10Sequence analysisAdd BLAST25
Repeati305 – 316LRR 11Sequence analysisAdd BLAST12
Repeati317 – 339LRR 12Sequence analysisAdd BLAST23
Repeati340 – 363LRR 13Sequence analysisAdd BLAST24
Repeati364 – 387LRR 14Sequence analysisAdd BLAST24
Repeati388 – 411LRR 15Sequence analysisAdd BLAST24
Repeati413 – 435LRR 16Sequence analysisAdd BLAST23
Repeati437 – 455LRR 17Sequence analysisAdd BLAST19

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000020436

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P90920

Identification of Orthologs from Complete Genome Data

More...
OMAi
KMLPPGY

Database of Orthologous Groups

More...
OrthoDBi
189363at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P90920

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P90920-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRWLTLIAVA HLIAFLSSAE ITCPRIPEKC DCKISKSMII LSCNGEDVKT
60 70 80 90 100
IAQTVGTSQI DELHILNGTD VKIESLPFNG LRTIAILNST LQSFSPTAWR
110 120 130 140 150
HVEATIEHIT INGNELKTVP VFGNLSTLMS MNLNSNQISS IPDKAFNGLS
160 170 180 190 200
ALTQLRLENN AICDFPPKSL DAVKASLVLL DVSGNCLDAI PAQILRNAAN
210 220 230 240 250
LMYLDLGSNN ISEINNFELM NLPFLRELRV QNNTLRRIHP MAFMNVPQLQ
260 270 280 290 300
YLYLQDNIIS TLDGNRLQGF KNLEVLDVSN NALYALPSLK DLPNLKQVRV
310 320 330 340 350
DGNLITKIET LAFSNNPNLQ LISVQNNNIV QISRNSFESL DKLVVLLVGN
360 370 380 390 400
NSLAKIERGM FDGMKNLQQL SIRNNTLTAL DASSFAQLAH LTTLDLGHNK
410 420 430 440 450
IHDIEEGTFD KLSKLFWLDL SNNKISGFKT SVFKKKISNI LLDGNQLICD
460 470 480 490 500
ESFNEFLTYL IANKVRTFLP FQQEIMCHGP EKYAGVRLKD LMMKKANETL
510 520 530 540 550
SEGSRLLGVP QGSNQHSLLS SFLPSLGPLG TLNGAGGAAI PLVNTLTNTI
560 570 580 590 600
PALRSIPGFG GNIPVGTGAS SVPNKNLNDA IEGFTGPLVR FATGGQPVAS
610 620 630 640 650
DIEQLIRSIP NMVVNVPGFG DIDLSKMDPT MIQYVLNGGQ IPGIDKATLD
660 670 680 690 700
KIVKQTMNKM HTAAAANLAG NPVEGQEKVL PPLDKLPSGL VTQVMSGEPL
710 720 730 740 750
PGLNENQTKI IMEYYTHQMP GMDGIPARPV ESQGNTTANN MFNPAMFDLL
760 770 780 790 800
KMLPPGYNLS KIPMEVIAAV TRGEVPDMRL LPEDLLEHFK QHTTSLTSMF
810 820 830 840 850
AGATAKNISI EEILEKLPVF VRPELSTFVP YDINELTSEM VLEQEQNERH
860 870 880 890 900
RNIRIITAIA LAFVGAVTVV VIIFFVNYTK KQRRLRKSLV YRSSPSSSGS
910 920 930 940 950
SGQNAANESG RSSAAPSPIR PPLMNIPKTP NNRTMESTFG QPQLCSTLLE
960
NPQAVSHRSR H
Length:961
Mass (Da):105,365
Last modified:January 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i486ABFEA9A5AAF4B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JQ292908 mRNA Translation: AEZ55700.1
Z81098 Genomic DNA Translation: CAB03182.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T23395

NCBI Reference Sequences

More...
RefSeqi
NP_492348.1, NM_059947.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K07A12.2.1; K07A12.2.1; WBGene00010621

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172670

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_K07A12.2

UCSC genome browser

More...
UCSCi
K07A12.2 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ292908 mRNA Translation: AEZ55700.1
Z81098 Genomic DNA Translation: CAB03182.1
PIRiT23395
RefSeqiNP_492348.1, NM_059947.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi38103, 1 interactor
DIPiDIP-24762N
STRINGi6239.K07A12.2

Proteomic databases

EPDiP90920
PaxDbiP90920
PeptideAtlasiP90920
PRIDEiP90920

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK07A12.2.1; K07A12.2.1; WBGene00010621
GeneIDi172670
KEGGicel:CELE_K07A12.2
UCSCiK07A12.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172670
WormBaseiK07A12.2 ; CE11866 ; WBGene00010621 ; egg-6

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000159318
HOGENOMiHOG000020436
InParanoidiP90920
OMAiKMLPPGY
OrthoDBi189363at2759
PhylomeDBiP90920

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P90920

Gene expression databases

BgeeiWBGene00010621 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 12 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEGG6_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P90920
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: January 1, 1998
Last modified: September 18, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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