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Entry version 150 (10 Feb 2021)
Sequence version 5 (13 Sep 2004)
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Protein

Protein madd-4

Gene

madd-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of an extracellular matrix cue that is involved in the guidance of dorsoventral midline migrations and in the specification of postsynaptic domains at neuromuscular junctions (NMJs) (PubMed:22014523, PubMed:24896188, PubMed:25122090, PubMed:26028575, PubMed:26028574). Acts as a ligand for the netrin receptor unc-40 and the neuroligin receptor nlg-1 (PubMed:22014523, PubMed:26028575, PubMed:25122090, PubMed:24896188). Secreted by the dorsal and ventral nerve cords to attract sensory axons and muscle membrane extensions called muscle arms (PubMed:22014523). In parallel with unc-6 and slt-1, involved in the netrin receptor unc-40 dependent guidance of the AVM and PVM mechanosensory axons along the dorsal-ventral axis (PubMed:22014523). The unc-40 coreceptor eva-1 is enhancing the responsiveness of unc-40 to the madd-4 guidance cue to attract the muscle arm extensions and AVM mechanosensory axons towards the dorsoventral midline (PubMed:25122090). Acts as a synaptic organizer and is required for the specification of inhibitory GABAergic and excitatory cholinergic identities of postsynaptic domains at neuromuscular junctions (NMJs) (PubMed:24896188, PubMed:26028575, PubMed:26028574). Required for the recruitment of unc-40 to both cholinergic and GABAergic NMJs (PubMed:26028575). Promotes the clustering of ACh receptors and GABA(A) receptors at postsynaptic sites during synaptogenesis (PubMed:24896188). The binding to the presynaptic adhesion protein nrx-1 and to the neuroligin nlg-1 at postsynaptic sites promotes clustering of GABAergic receptors at postsynaptic NMJs, thereby contributing to normal GABAergic synaptic transmission (PubMed:26028574).5 Publications
Isoform a and isoform c: Promotes the clustering of acetylcholine receptors (AChR) at excitatory cholinergic synapses of NMJs via the netrin receptor unc-40.1 Publication
Acts as a guidance cue in the attraction of muscle membrane extensions (muscle arms) to the dorsal cord and in cooperation with unc-6 to the ventral cord via the netrin receptor unc-40 and via the unc-40 coreceptor eva-1 (PubMed:22014523, PubMed:25122090). Together with nrx-1, clusters netrin receptor unc-40 and neuroligin nlg-1 at postsynaptic sites of GABAergic NMJs, thereby promoting the recruitment of GABA(A) receptors at GABAergic synapses (PubMed:24896188, PubMed:26028575, PubMed:26028574). Prevents the recruitment of GABAergic receptors to cholinergic synapses (PubMed:24896188).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • dorsal/ventral axon guidance Source: WormBase
  • extracellular matrix organization Source: GO_Central
  • synapse organization Source: WormBase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5173214, O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein madd-4Curated
Alternative name(s):
Punctin1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:madd-4Imported
ORF Names:F53B6.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F53B6.2a ; CE36859 ; WBGene00009958 ; madd-4
F53B6.2b ; CE32429 ; WBGene00009958 ; madd-4
F53B6.2c ; CE32428 ; WBGene00009958 ; madd-4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projection, Extracellular matrix, Secreted, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Disrupts the clustering of the cholinergic receptor subunits unc-29, unc-38 and acr-16 and the GABAergic receptor subunit unc-49 at postsynaptic domains of neuromuscular junctions (NMJs), and the receptors are redistributed to extrasynaptic areas (PubMed:24896188, PubMed:26028575). Loss of neuroligin receptor nlg-1 and netrin receptor unc-40 localization to NMJs (PubMed:26028575). Isoform a and isoform c: Defects in AChR localization to cholinergic synapses (PubMed:24896188). Decreased AChR-dependent currents triggered by motoneuron stimulation (PubMed:24896188). Isoform b: Extensive dorsal muscle arm extension defects and weaker ventral muscle arm extension defects (PubMed:24896188, PubMed:22014523). Relocalization of GABAergic receptors from GABAergic to cholinergic synapses (PubMed:24896188, PubMed:26028575). Redistribution of the neuroligin receptor nlg-1 from GABAergic to cholinergic NMJs (PubMed:26028575). In a unc-6 mutant background, extensive ventral muscle arm extension defects (PubMed:22014523). Loss of unc-40 localization at GABAergic NMJs (PubMed:26028575).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi398R → H: Disrupts the attraction of the muscle arm extensions. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500416177524 – 1045Protein madd-4Sequence analysisAdd BLAST1022

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi35 ↔ 65PROSITE-ProRule annotation
Disulfide bondi39 ↔ 70PROSITE-ProRule annotation
Disulfide bondi50 ↔ 55PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi268N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi280N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi674 ↔ 722PROSITE-ProRule annotation
Glycosylationi730N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi781N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi899N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi906N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P90884

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform a: Expressed in the commissural GABAergic and cholinergic motor neurons in the first larval stage but only in the cholinergic motor neurons in later larval stages and in adult animals (PubMed:22014523). At the L1 larval stage, mainly localized at the nerve ring and at the dorsal cord (PubMed:24896188). Isoform b: Expressed in the commissural GABAergic and cholinergic motor neurons whose cell bodies reside in the ventral nerve cord and which extend axons into the ventral and dorsal nerve cord (PubMed:22014523, PubMed:24896188). Also expressed in the head neurons RIA, RIC, lateral IL1s, lateral IL2s, OLLs, RMEs and SABs, all of which extend axons into the nerve ring (PubMed:22014523, PubMed:24896188). Expressed in the embryogenic blast cells and the corresponding terminally differentiated ventral cord motor neurons and head neurons (PubMed:22014523).2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform a: Expressed in larval stages L1 and L2 and in adult animals. Isoform b: Expressed in embryos, larval stages L1 and L2 and in adult animals.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00009958, Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with eva-1 (via the SUEL-type lectin domain) (PubMed:25122090).

Interacts with unc-5 (PubMed:25122090).

Interacts with unc-40; the interaction is required for the localization of unc-40 to postsynaptic domains (PubMed:25122090, PubMed:26028575). Isoform a forms homodimers and heterodimers with isoform b (PubMed:24896188). Isoform b forms homodimers and heterodimers with isoform a (PubMed:24896188). Isoform b interacts with nlg-1 (via extracellular domain); the interaction is required for nlg-1 localization to postsynaptic domains (PubMed:26028574, PubMed:26028575). Isoform b interacts (via the Ig-like C2-type domain) with nrx-1 (via C-terminus) (PubMed:26028574).

4 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F53B6.2a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P90884

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 71TSP type-1 1PROSITE-ProRule annotationAdd BLAST48
Domaini236 – 292TSP type-1 2PROSITE-ProRule annotationAdd BLAST57
Domaini294 – 510TSP type-1 3PROSITE-ProRule annotationAdd BLAST217
Domaini512 – 572TSP type-1 4PROSITE-ProRule annotationAdd BLAST61
Domaini576 – 635TSP type-1 5Sequence analysisAdd BLAST60
Domaini637 – 732Ig-like C2-typePROSITE-ProRule annotationAdd BLAST96
Domaini811 – 873TSP type-1 6Sequence analysisAdd BLAST63
Domaini932 – 990TSP type-1 7PROSITE-ProRule annotationAdd BLAST59
Domaini1004 – 1041PLACPROSITE-ProRule annotationAdd BLAST38

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Ig-like C2-type domain is required for the attraction of the muscle arm extensions.1 Publication

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3538, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P90884

Identification of Orthologs from Complete Genome Data

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OMAi
STGIHCD

Database of Orthologous Groups

More...
OrthoDBi
38261at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P90884

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 9 hits
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013273, ADAMTS/ADAMTS-like
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 1 hit
PF00090, TSP_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857, ADAMTSFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00209, TSP1, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit
SSF82895, SSF82895, 9 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
Isoform aImported (identifier: P90884-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKCSYTVVFL LFYLLIASFH VDALSWAAWS PWSSCTKTCG GGVSRQLRRC
60 70 80 90 100
LTSKCSGESV RFKVCAQKTC ESKSRLARDT ICGGEEIVSR GQCEVVCRSR
110 120 130 140 150
LTGANFLWRV DDGTPCQAAT SRAVCSKGSC QIVGCDGLIS SSFRFDACGV
160 170 180 190 200
CGGRGDTCDN GKFIWKVSEE YTACASNCDD IVDWSGAGRS IASTSQPIVV
210 220 230 240 250
CVNAITGRVV PEKLCADKLR PKVEARPCPM LICPSRCRWM AADWTECVPH
260 270 280 290 300
CGEGTRKREV YCVQTAHNVT VHVPDTFCEN GTRPAAEENC VSTSCGRWEA
310 320 330 340 350
GKWSKCTASC GQGVRRRHVA CVGGSDCDEG GRPRQETTCY AGIPCSIATN
360 370 380 390 400
SLDWNDRAYL DGNTFGSMDN HNDWQAPRLV AGEWSTCSST CGTGVMSRTV
410 420 430 440 450
ECVAVNPISS APIKLPMSEC QDQEQPKLFE SCEVRSCPLQ EDSKLSEDEA
460 470 480 490 500
PYQWRYGDWT QCSASCLGGK QKAALKCIQV STGKSVQWSQ CDARRRPPEK
510 520 530 540 550
SRPCNQHPCP PFWLTSKYSD CSMSCGSGTA RRSVKCAQTV SKTDGADAHI
560 570 580 590 600
VLRDDRCHFK KPQETETCNV VACPATWVTA QWTECSRSCD SGERRRQVWC
610 620 630 640 650
EIRDSRGKTQ RRPDVECDAN TKPQTVEVCS FGSCSRPELL SNRVFEQNAE
660 670 680 690 700
QKKLTLGIGG VATLYQGTSI KIKCPAKKFD KKKIYWKKNG KKIKNDAHIK
710 720 730 740 750
VSANGNLRVF HARMEDAGVY ECFTDRLQGN VTLNFKYRDF PASRVDLAPK
760 770 780 790 800
PQIPSTKNRQ RVQVSKEDVL REQASVLHKM NVSLIEALLT APNDEKAREQ
810 820 830 840 850
LRKYGNELVA RWDIGHWSEC RQKTCHVAGY QARGISCKVT FHGEIRNVDN
860 870 880 890 900
SICESLASVR PPETRPCHRE DCPRWEASQW SECSSQRCVS SMLAQKRRNV
910 920 930 940 950
TCRFTNGTSV DIQHCDITNR PATTMDCPNQ NCKAEWRTSD WGSCSSECGT
960 970 980 990 1000
GGVQLRLLSC VWISSGRPAG RNCEQMRRPH SARACVADEP LPPCMPTASA
1010 1020 1030 1040
LYQRDASCQD QSRFCDIIKL FHSCDSLEVR QKCCSTCTFV ERKKF
Length:1,045
Mass (Da):116,125
Last modified:September 13, 2004 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF78269D1D50228B1
GO
Isoform bImported (identifier: P90884-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-351: MKCSYTVVFL...GIPCSIATNS → MLPLLLILSAPLGVSAF

Note: Produced by alternative promoter usage.Curated
Show »
Length:711
Mass (Da):79,946
Checksum:i9695028B9636AE94
GO
Isoform cImported (identifier: P90884-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-238: Missing.

Note: Produced by alternative splicing of isoform a.Curated
Show »
Length:1,043
Mass (Da):115,865
Checksum:iA670346A1DBF1AF0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0592741 – 351MKCSY…IATNS → MLPLLLILSAPLGVSAF in isoform b. CuratedAdd BLAST351
Alternative sequenceiVSP_059275237 – 238Missing in isoform c. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB03121.3
BX284601 Genomic DNA Translation: CAD56586.1
BX284601 Genomic DNA Translation: CCH63796.1

Protein sequence database of the Protein Information Resource

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PIRi
T22545

NCBI Reference Sequences

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RefSeqi
NP_001250933.1, NM_001264004.1 [P90884-3]
NP_492405.3, NM_060004.4 [P90884-1]
NP_871884.1, NM_182084.5 [P90884-2]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F53B6.2a.1; F53B6.2a.1; WBGene00009958 [P90884-1]
F53B6.2b.1; F53B6.2b.1; WBGene00009958 [P90884-2]
F53B6.2c.1; F53B6.2c.1; WBGene00009958 [P90884-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
172706

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F53B6.2

UCSC genome browser

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UCSCi
F53B6.2b, c. elegans [P90884-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB03121.3
BX284601 Genomic DNA Translation: CAD56586.1
BX284601 Genomic DNA Translation: CCH63796.1
PIRiT22545
RefSeqiNP_001250933.1, NM_001264004.1 [P90884-3]
NP_492405.3, NM_060004.4 [P90884-1]
NP_871884.1, NM_182084.5 [P90884-2]

3D structure databases

SMRiP90884
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F53B6.2a

Proteomic databases

PaxDbiP90884

Genome annotation databases

EnsemblMetazoaiF53B6.2a.1; F53B6.2a.1; WBGene00009958 [P90884-1]
F53B6.2b.1; F53B6.2b.1; WBGene00009958 [P90884-2]
F53B6.2c.1; F53B6.2c.1; WBGene00009958 [P90884-3]
GeneIDi172706
KEGGicel:CELE_F53B6.2
UCSCiF53B6.2b, c. elegans [P90884-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
172706
WormBaseiF53B6.2a ; CE36859 ; WBGene00009958 ; madd-4
F53B6.2b ; CE32429 ; WBGene00009958 ; madd-4
F53B6.2c ; CE32428 ; WBGene00009958 ; madd-4

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
InParanoidiP90884
OMAiSTGIHCD
OrthoDBi38261at2759
PhylomeDBiP90884

Enzyme and pathway databases

ReactomeiR-CEL-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

Protein Ontology

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PROi
PR:P90884

Gene expression databases

BgeeiWBGene00009958, Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

Gene3Di2.20.100.10, 9 hits
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013273, ADAMTS/ADAMTS-like
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF07679, I-set, 1 hit
PF00090, TSP_1, 1 hit
PRINTSiPR01857, ADAMTSFAMILY
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00209, TSP1, 9 hits
SUPFAMiSSF48726, SSF48726, 1 hit
SSF82895, SSF82895, 9 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS50900, PLAC, 1 hit
PS50092, TSP1, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMADD4_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P90884
Secondary accession number(s): I2HA89, Q8I4I1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2017
Last sequence update: September 13, 2004
Last modified: February 10, 2021
This is version 150 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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