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Entry version 152 (26 Feb 2020)
Sequence version 2 (01 May 1999)
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Protein

Proteasome subunit beta

Gene

pbs-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleavage of peptide bonds with very broad specificity.UniRule annotation EC:3.4.25.1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Threonine proteaseUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-CEL-195253 Degradation of beta-catenin by the destruction complex
R-CEL-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-CEL-350562 Regulation of ornithine decarboxylase (ODC)
R-CEL-382556 ABC-family proteins mediated transport
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-4641258 Degradation of DVL
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69017 CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
T01.A08

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pbs-7Imported
ORF Names:CELE_F39H11.5Imported, F39H11.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
F39H11.5 ; CE20761 ; WBGene00003953 ; pbs-7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation, ProteasomeImported

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P90868

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P90868

PeptideAtlas

More...
PeptideAtlasi
P90868

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003953 Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-26967N

Protein interaction database and analysis system

More...
IntActi
P90868, 8 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F39H11.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P90868

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0185 Eukaryota
ENOG410YAMA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000698

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_072435_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P90868

KEGG Orthology (KO)

More...
KOi
K02736

Identification of Orthologs from Complete Genome Data

More...
OMAi
NWDIAHL

Database of Orthologous Groups

More...
OrthoDBi
1228942at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P90868

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03760 proteasome_beta_type_4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.20.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR016295 Proteasome_beta4
IPR001353 Proteasome_sua/b

The PANTHER Classification System

More...
PANTHERi
PTHR11599:SF5 PTHR11599:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00227 Proteasome, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001213 Psome_endopept_beta, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56235 SSF56235, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P90868-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAHDEVQRT LNPTCTGTSV IALQYKTGVV VLTDRVVSYG KMARYKNVSR
60 70 80 90 100
QYKVNDNVLI AFGGDHADFH WLQNVIERQV LLWKRFDQDI GPKALHGYLT
110 120 130 140 150
SLLYAKRCKM NPVWNTLVVA GVEEEEKNNK ETSTPFIGVI TQKGCAYQVK
160 170 180 190 200
HIATGLGAFL LNQAVEDEWR KKGEDLSREE AEAVLRKSLE LTLYHDCVAD
210 220 230
NEFEIGRVDA TEGVVLGKEE KIIGDWSIAE TNCQYE
Length:236
Mass (Da):26,682
Last modified:May 1, 1999 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFA2C116C799DABB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB03081.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T22003

NCBI Reference Sequences

More...
RefSeqi
NP_492354.1, NM_059953.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F39H11.5.1; F39H11.5.1; WBGene00003953

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
172674

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F39H11.5

UCSC genome browser

More...
UCSCi
F39H11.5.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB03081.1
PIRiT22003
RefSeqiNP_492354.1, NM_059953.4

3D structure databases

SMRiP90868
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-26967N
IntActiP90868, 8 interactors
STRINGi6239.F39H11.5

Protein family/group databases

MEROPSiT01.A08

Proteomic databases

EPDiP90868
PaxDbiP90868
PeptideAtlasiP90868

Genome annotation databases

EnsemblMetazoaiF39H11.5.1; F39H11.5.1; WBGene00003953
GeneIDi172674
KEGGicel:CELE_F39H11.5
UCSCiF39H11.5.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172674
WormBaseiF39H11.5 ; CE20761 ; WBGene00003953 ; pbs-7

Phylogenomic databases

eggNOGiKOG0185 Eukaryota
ENOG410YAMA LUCA
GeneTreeiENSGT00390000000698
HOGENOMiCLU_072435_2_0_1
InParanoidiP90868
KOiK02736
OMAiNWDIAHL
OrthoDBi1228942at2759
PhylomeDBiP90868

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-CEL-195253 Degradation of beta-catenin by the destruction complex
R-CEL-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-CEL-350562 Regulation of ornithine decarboxylase (ODC)
R-CEL-382556 ABC-family proteins mediated transport
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-4641258 Degradation of DVL
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69017 CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiWBGene00003953 Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

CDDicd03760 proteasome_beta_type_4, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR016295 Proteasome_beta4
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF5 PTHR11599:SF5, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PIRSFiPIRSF001213 Psome_endopept_beta, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP90868_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P90868
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1999
Last modified: February 26, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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