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Entry version 130 (18 Sep 2019)
Sequence version 1 (01 May 1997)
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Protein

alpha-1,2-Mannosidase

Gene

CELE_F10C2.5

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidaseUniRule annotation, Hydrolase

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH47 Glycoside Hydrolase Family 47

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
alpha-1,2-MannosidaseUniRule annotation (EC:3.2.1.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CELE_F10C2.5Imported, F10C2.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F10C2.5 ; CE09309 ; WBGene00008646

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500416176619 – 781alpha-1,2-MannosidaseSequence analysisAdd BLAST763

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P90830

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P90830

PeptideAtlas

More...
PeptideAtlasi
P90830

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00008646 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.F10C2.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P90830

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili551 – 571Sequence analysisAdd BLAST21
Coiled coili607 – 641Sequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 47 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2429 Eukaryota
ENOG410XS6F LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167182

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000022476

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P90830

KEGG Orthology (KO)

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KOi
K10085

Identification of Orthologs from Complete Genome Data

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OMAi
MVESLMY

Database of Orthologous Groups

More...
OrthoDBi
434316at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P90830

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.50.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR001382 Glyco_hydro_47
IPR036026 Seven-hairpin_glycosidases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01532 Glyco_hydro_47, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00747 GLYHDRLASE47

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48225 SSF48225, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P90830-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITRKAIFFL ALASIIQASD DSEAPDNKKS SIRFTPSVID SYREKVQKMF
60 70 80 90 100
YHAYNGYLDH AFPLDELKPI TCVGQDTWGS FSLSLIDALD TLLVMGNTTE
110 120 130 140 150
FRRAVSLVLE KARDDANVNV SVFETNIRVV GGLISAHMLA GRHKDLVVDW
160 170 180 190 200
EGYPCDSPLL KLAVKMADRL MPAFNTETGM PYGTVNLKYG VHKDETPITC
210 220 230 240 250
TAGVGTFLIE FGTLSRLTGD DKYEKVALKA LDALWSTRSP IGLVGNHINV
260 270 280 290 300
QTGQWTATDS GIGAGVDSYF EYLAKGAYLF RRPSLMKQFH EHATSINKHV
310 320 330 340 350
RKGEWFMWVS MAKGSVSLPI FQSLEAFWPG TLTMVGDVQD ASRIMLTYSE
360 370 380 390 400
VIRKYGFPPE FYNIHNEEPG EKRAAFPLRP EMVESLMYLY RATKDETWLE
410 420 430 440 450
LGAEMIDAIE SSARTKCGYA TINNVKEHSI EDRMESFFLA ETTKYLYLLF
460 470 480 490 500
DPTNFIHSKG DQARILTSPK NLTCVIYGGG YIFNTEAHPV DPGMLDCCSV
510 520 530 540 550
QAKRDQEVGV KQVNNGDEHE KMNRTEKGGE KYFENQYGKN ENLIEFEVDE
560 570 580 590 600
KLKKESEKRK IELEAEKVKE NSHKAMLKVR EILVRAHQKD EAMQRNGETS
610 620 630 640 650
DSARKLMDQL YKAYPNHTAE LENLNKEAII EFEELQHLED IRELVREIPI
660 670 680 690 700
PEVFCEKCCV PLHEIVDSVV LRVLMADVYE YHFYPTRKTK FLHGPVCWLE
710 720 730 740 750
ETPRIEDDYK NEPPSVNTEK WNSPLFTSDQ ASLNDFIGDD LETVRKFGFK
760 770 780
TLLAPGYKKL DKLIAGQNIA LRRKKSWYYE V
Length:781
Mass (Da):89,050
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD006B1CC85E86859
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB04078.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20699

NCBI Reference Sequences

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RefSeqi
NP_506018.1, NM_073617.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F10C2.5.1; F10C2.5.1; WBGene00008646

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179653

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F10C2.5

UCSC genome browser

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UCSCi
F10C2.5 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB04078.1
PIRiT20699
RefSeqiNP_506018.1, NM_073617.3

3D structure databases

SMRiP90830
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.F10C2.5

Protein family/group databases

CAZyiGH47 Glycoside Hydrolase Family 47

Proteomic databases

EPDiP90830
PaxDbiP90830
PeptideAtlasiP90830

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF10C2.5.1; F10C2.5.1; WBGene00008646
GeneIDi179653
KEGGicel:CELE_F10C2.5
UCSCiF10C2.5 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179653
WormBaseiF10C2.5 ; CE09309 ; WBGene00008646

Phylogenomic databases

eggNOGiKOG2429 Eukaryota
ENOG410XS6F LUCA
GeneTreeiENSGT00940000167182
HOGENOMiHOG000022476
InParanoidiP90830
KOiK10085
OMAiMVESLMY
OrthoDBi434316at2759
PhylomeDBiP90830

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P90830

Gene expression databases

BgeeiWBGene00008646 Expressed in 5 organ(s), highest expression level in germ line (C elegans)

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR012341 6hp_glycosidase-like_sf
IPR001382 Glyco_hydro_47
IPR036026 Seven-hairpin_glycosidases
PfamiView protein in Pfam
PF01532 Glyco_hydro_47, 1 hit
PRINTSiPR00747 GLYHDRLASE47
SUPFAMiSSF48225 SSF48225, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP90830_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P90830
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: September 18, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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