UniProtKB - P90795 (GPDM_CAEEL)
Protein
Probable glycerol-3-phosphate dehydrogenase, mitochondrial
Gene
gpdh-3
Organism
Caenorhabditis elegans
Status
Functioni
Catalytic activityi
- EC:1.1.5.3
Cofactori
FADBy similarity
Activity regulationi
Calcium-binding enhances the activity of the enzyme.By similarity
: glycerol degradation via glycerol kinase pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).Proteins known to be involved in this subpathway in this organism are:
- Probable glycerol-3-phosphate dehydrogenase, mitochondrial (gpdh-3)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 76 – 104 | FADSequence analysisAdd BLAST | 29 | |
Calcium bindingi | 673 – 684 | PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC
GO - Biological processi
- glycerol-3-phosphate metabolic process Source: InterPro
- glycerol catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Calcium, FAD, Flavoprotein, Metal-binding |
Enzyme and pathway databases
Reactomei | R-CEL-1483166, Synthesis of PA R-CEL-163560, Triglyceride catabolism |
UniPathwayi | UPA00618;UER00673 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)Short name: GPD-M Short name: GPDH-M |
Gene namesi | Name:gpdh-3Imported ORF Names:T25G3.4Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | T25G3.4 ; CE14180 ; WBGene00012031 ; gpdh-3 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: GO_Central
Other locations
- glycerol-3-phosphate dehydrogenase complex Source: InterPro
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 43 | MitochondrionAdd BLAST | 43 | |
ChainiPRO_0000010432 | 44 – 722 | Probable glycerol-3-phosphate dehydrogenase, mitochondrialAdd BLAST | 679 |
Proteomic databases
EPDi | P90795 |
PaxDbi | P90795 |
PeptideAtlasi | P90795 |
Expressioni
Gene expression databases
Bgeei | WBGene00012031, Expressed in adult organism and 5 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 624 – 659 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 660 – 695 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.Curated
Keywords - Domaini
Repeat, Transit peptidePhylogenomic databases
eggNOGi | KOG0042, Eukaryota |
GeneTreei | ENSGT00390000001718 |
HOGENOMi | CLU_015740_3_1_1 |
InParanoidi | P90795 |
OMAi | AHGFSKT |
OrthoDBi | 669193at2759 |
PhylomeDBi | P90795 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit PF13499, EF-hand_7, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00977, FAD_G3PDH_1, 1 hit PS00978, FAD_G3PDH_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P90795-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWVRFTKTG VAVVATSAAA VLALDMTNER RFQRQVKDHF RTVHADRLAE
60 70 80 90 100
LNKRAPSALP TRKDILTNLS KGEEFDVLII GGGATGAGVA LDAQTRGLKT
110 120 130 140 150
ALVELDDFSS GTSSRSTKLI HGGVRYLQAA IMKLDLEQYR MVKEALFERH
160 170 180 190 200
NLLEIAPHLS SPLPIMLPIY KLWQVPYYWS GIKAYDFVSG KRVLKNSFFI
210 220 230 240 250
NKSQALERFP MLRNESLKGA LIYYDGQHND ARMNLAIILT AIRHGAACAN
260 270 280 290 300
HVRVEKLNKD ETGKVIGAHV RDMVTGGEWD IKAKAVINAT GPFTDSIRLM
310 320 330 340 350
GDPETARPIC APSSGVHITL PGYYSPSNTG LLDPDTSDGR VIFFLPWERM
360 370 380 390 400
TIAGTTDAPS DVTLSPQPTD HDIEFILQEI RGYLSKDVSV RRGDVMSAWS
410 420 430 440 450
GLRPLVRDPN KKDTKSLARN HIIEVGKSGL ITIAGGKWTT YRHMAEETVD
460 470 480 490 500
RVVEVHGLKT ENGCVTPGLL LEGAHDWNSL QYIHLVQDYG MEVDVAQHLS
510 520 530 540 550
NTYGDRAFVV ARMCKMTGKR WPIVGQRLHP EFPYLDAEVR YAVREYACTA
560 570 580 590 600
IDVIARRMRL AFLNTYAAHE VLPDVVRVMG QELGWSSAEQ RAQLEKARTF
610 620 630 640 650
IDMEMGQNAK QTAVSNVALN LTKEEMQRAK ERFQQLDKDR KGHITVNDLR
660 670 680 690 700
KHFREHNQKI DERVLHELLN EVDLNKNGEI EIAEFFQLYS GLKGGQLTGN
710 720
RLVGYLDEIH GTPSVNRACG GI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284601, Z73906 Genomic DNA Translation: CAA96690.1 |
PIRi | T20362 |
RefSeqi | NP_492115.1, NM_059714.4 |
Genome annotation databases
EnsemblMetazoai | T25G3.4.1; T25G3.4.1; WBGene00012031 |
GeneIDi | 172509 |
KEGGi | cel:CELE_T25G3.4 |
UCSCi | T25G3.4, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284601, Z73906 Genomic DNA Translation: CAA96690.1 |
PIRi | T20362 |
RefSeqi | NP_492115.1, NM_059714.4 |
3D structure databases
SMRi | P90795 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 37951, 9 interactors |
STRINGi | 6239.T25G3.4 |
Proteomic databases
EPDi | P90795 |
PaxDbi | P90795 |
PeptideAtlasi | P90795 |
Genome annotation databases
EnsemblMetazoai | T25G3.4.1; T25G3.4.1; WBGene00012031 |
GeneIDi | 172509 |
KEGGi | cel:CELE_T25G3.4 |
UCSCi | T25G3.4, c. elegans |
Organism-specific databases
CTDi | 172509 |
WormBasei | T25G3.4 ; CE14180 ; WBGene00012031 ; gpdh-3 |
Phylogenomic databases
eggNOGi | KOG0042, Eukaryota |
GeneTreei | ENSGT00390000001718 |
HOGENOMi | CLU_015740_3_1_1 |
InParanoidi | P90795 |
OMAi | AHGFSKT |
OrthoDBi | 669193at2759 |
PhylomeDBi | P90795 |
Enzyme and pathway databases
UniPathwayi | UPA00618;UER00673 |
Reactomei | R-CEL-1483166, Synthesis of PA R-CEL-163560, Triglyceride catabolism |
Miscellaneous databases
PROi | PR:P90795 |
Gene expression databases
Bgeei | WBGene00012031, Expressed in adult organism and 5 other tissues |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.10.8.870, 1 hit 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR031656, DAO_C IPR038299, DAO_C_sf IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR006076, FAD-dep_OxRdtase IPR036188, FAD/NAD-bd_sf IPR000447, G3P_DH_FAD-dep |
PANTHERi | PTHR11985, PTHR11985, 1 hit |
Pfami | View protein in Pfam PF01266, DAO, 1 hit PF16901, DAO_C, 1 hit PF13499, EF-hand_7, 1 hit |
PRINTSi | PR01001, FADG3PDH |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF51905, SSF51905, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS00977, FAD_G3PDH_1, 1 hit PS00978, FAD_G3PDH_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPDM_CAEEL | |
Accessioni | P90795Primary (citable) accession number: P90795 Secondary accession number(s): Q22793 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families