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Entry version 154 (11 Dec 2019)
Sequence version 5 (18 Mar 2008)
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Protein
Submitted name:

Uncharacterized protein

Gene

che-11

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-5610787 Hedgehog 'off' state
R-CEL-5620924 Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:che-11Imported
ORF Names:C27A7.4Imported, CELE_C27A7.4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
C27A7.4 ; CE42072 ; WBGene00000490 ; che-11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P90757

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
WBGene00000490 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1289 Intraflagellar transport complex A

Database of interacting proteins

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DIPi
DIP-61855N

Protein interaction database and analysis system

More...
IntActi
P90757, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C27A7.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P90757

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni156 – 183DisorderedSequence analysisAdd BLAST28
Regioni1410 – 1437DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili884 – 904Sequence analysisAdd BLAST21
Coiled coili1303 – 1330Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1410 – 1430PolyampholyteSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3617 Eukaryota
ENOG410XSS4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153417

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000022469

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P90757

KEGG Orthology (KO)

More...
KOi
K19672

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVHAFEV

Database of Orthologous Groups

More...
OrthoDBi
41516at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P90757

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P90757-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPFLIEWAP HCGWICVVTQ DETTGEANVA FSDHSGSVQE KGPSKPGSVS
60 70 80 90 100
CVRWHPKKQF VVVGWKDGGV CFIPKGGNVS HTVVETYPFP NQGVDWSHDG
110 120 130 140 150
TVLMTLHNPS SVHLYSYMVI GEEISTSNIM QIELNDQITL WCKRLSYDKF
160 170 180 190 200
KPSKISVTDD DSGVDESPFG SKESLAERRD EKSTVPKGTE FLFAGKSGTI
210 220 230 240 250
YGVDNDRQRT IHKLDSEILF MGYCETISII IVFTRDCFIF HLAKGTSEMR
260 270 280 290 300
CAERVKVKLG GKSEKYSLEL DDGILVMCYG EKEIRVWDLI KEENGTIALD
310 320 330 340 350
VNKGFQPDET INVVTVNGKR GVITAATSLN NIAEWKRKRT DTNVESAWNL
360 370 380 390 400
SPSTHVDSQV SLIRWSPILS TAALITEEDL VLIGENSLTV KMRGKMAAIQ
410 420 430 440 450
TSSNSFTLLH ATSGVSQDLK LSIPSAKGIC LGEKQLVVWN EDTVVTYDVQ
460 470 480 490 500
TSLATIQCTS FSCNTTSVAI VNQNLYCIEK DKIFARTLQG TLRQEISLPE
510 520 530 540 550
IEGDPEILEV NRCWMAVATT NGFIRIYNLS AKDAQQEHNS KYIIENVKNF
560 570 580 590 600
YKFHTIRINH TGNKVAVSYL EDVSTVAERL LVYDAELDAV SYFSFDRGMT
610 620 630 640 650
DTQEYETQAE LAHTSSGRPV TAAARKMARE QSRFQMMNHR PGAFEWDEND
660 670 680 690 700
ARYLVVECIH VEPESTDQRV LTAFVTSEHG IQLQGMQQKN LHCGKLVSVS
710 720 730 740 750
VPNFYFVRKS GWDEEDNRDE RTIGKTLVAK CLREFLGNEN CDESTRKAMM
760 770 780 790 800
DFSFYLTIGS MDAAFKAIQF IKSDSVWDHM ASMSIKTRRL DVAMVCLGHM
810 820 830 840 850
KNVRGARAVR RSQQNGENDS MKCAALAIEL SMLEEALIIY AQNERYDLMN
860 870 880 890 900
KLYQSQNMWS SAFEIAETKD RIHLRNTHYN YAKYLEARRD QASIEAAIEN
910 920 930 940 950
YEKAGVHAFE VFRMLKDYPK QIEQYVRRKR EESLYSWWGA YLESVGELEG
960 970 980 990 1000
AISFYSSAKD YYCMVRVKCI QGKTDEAARL AEESKDKAAC YLIGRMYEND
1010 1020 1030 1040 1050
GDVVKAVKFF TKARALSSAI RLAKEHDMKD RLANLCLMAG GSELVSAARY
1060 1070 1080 1090 1100
YEDLPGYAHK AVMLYHKAGM IGRALDLAFR TEQFSALDLI TKDLDAGTDP
1110 1120 1130 1140 1150
KILRRAAEFF ENNQNYEKAV NFLCLAKEFS GAVQLCKNRN VRVSDKFAEL
1160 1170 1180 1190 1200
MTPTKDDMPN VQERKQVLET VAELCLQQGA YSAAAKKFTQ AGDKLSAMRA
1210 1220 1230 1240 1250
LLKSGDIQKI RFFANTARNK EIYILAANFL QTTDWQDNQQ TMKDIETFYT
1260 1270 1280 1290 1300
KSQSFEHLGN FYKSVAIIEA EHLRTLDKSM GALEMAAVCV LEAEQKNMST
1310 1320 1330 1340 1350
TGLDALKEDL KKYVVQLRKL QSVLEVMKND AADGMRQLTT LAEESIDDDI
1360 1370 1380 1390 1400
VPCTRLFALI IEDHASRKNW KPAYRAITGL QKKVPNVDLE TFVETSTLDK
1410 1420 1430
VCDEMRMERV TKKKKEEVES DGEEVDFSHS LRRQNVS
Length:1,437
Mass (Da):162,477
Last modified:March 18, 2008 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FC68CBF07C2A258
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB02787.5

NCBI Reference Sequences

More...
RefSeqi
NP_506047.5, NM_073646.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C27A7.4.1; C27A7.4.1; WBGene00000490

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
179666

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C27A7.4

UCSC genome browser

More...
UCSCi
C27A7.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB02787.5
RefSeqiNP_506047.5, NM_073646.5

3D structure databases

SMRiP90757
ModBaseiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-1289 Intraflagellar transport complex A
DIPiDIP-61855N
IntActiP90757, 2 interactors
STRINGi6239.C27A7.4

Proteomic databases

PaxDbiP90757

Genome annotation databases

EnsemblMetazoaiC27A7.4.1; C27A7.4.1; WBGene00000490
GeneIDi179666
KEGGicel:CELE_C27A7.4
UCSCiC27A7.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179666
WormBaseiC27A7.4 ; CE42072 ; WBGene00000490 ; che-11

Phylogenomic databases

eggNOGiKOG3617 Eukaryota
ENOG410XSS4 LUCA
GeneTreeiENSGT00940000153417
HOGENOMiHOG000022469
InParanoidiP90757
KOiK19672
OMAiGVHAFEV
OrthoDBi41516at2759
PhylomeDBiP90757

Enzyme and pathway databases

ReactomeiR-CEL-5610787 Hedgehog 'off' state
R-CEL-5620924 Intraflagellar transport

Gene expression databases

BgeeiWBGene00000490 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP90757_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P90757
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: March 18, 2008
Last modified: December 11, 2019
This is version 154 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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