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Protein

Probable manganese-transporting ATPase catp-8

Gene

catp-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4834-aspartylphosphate intermediateBy similarity1
Metal bindingi822MagnesiumBy similarity1
Metal bindingi826MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: InterPro
  • cellular calcium ion homeostasis Source: GO_Central

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-transporting ATPase catp-8Curated (EC:3.6.3.-)
Alternative name(s):
Cation transporting ATPase 8Imported
Gene namesi
Name:catp-8Imported
ORF Names:C10C6.6Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiC10C6.6 ; CE30858 ; WBGene00007514 ; catp-8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 43ExtracellularSequence analysis6
Transmembranei44 – 69HelicalSequence analysisAdd BLAST26
Topological domaini70 – 185CytoplasmicSequence analysisAdd BLAST116
Transmembranei186 – 207HelicalSequence analysisAdd BLAST22
Topological domaini208 – 211ExtracellularSequence analysis4
Transmembranei212 – 230HelicalSequence analysisAdd BLAST19
Topological domaini231 – 394CytoplasmicSequence analysisAdd BLAST164
Transmembranei395 – 414HelicalSequence analysisAdd BLAST20
Topological domaini415 – 428ExtracellularSequence analysisAdd BLAST14
Transmembranei429 – 450HelicalSequence analysisAdd BLAST22
Topological domaini451 – 970CytoplasmicSequence analysisAdd BLAST520
Transmembranei971 – 990HelicalSequence analysisAdd BLAST20
Topological domaini991 – 997ExtracellularSequence analysis7
Transmembranei998 – 1014HelicalSequence analysisAdd BLAST17
Topological domaini1015 – 1032CytoplasmicSequence analysisAdd BLAST18
Transmembranei1033 – 1056HelicalSequence analysisAdd BLAST24
Topological domaini1057 – 1076ExtracellularSequence analysisAdd BLAST20
Transmembranei1077 – 1099HelicalSequence analysisAdd BLAST23
Topological domaini1100 – 1110CytoplasmicSequence analysisAdd BLAST11
Transmembranei1111 – 1130HelicalSequence analysisAdd BLAST20
Topological domaini1131 – 1147ExtracellularSequence analysisAdd BLAST17
Transmembranei1148 – 1170HelicalSequence analysisAdd BLAST23
Topological domaini1171 – 1178CytoplasmicSequence analysis8

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463571 – 1178Probable manganese-transporting ATPase catp-8CuratedAdd BLAST1178

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP90747
PaxDbiP90747
PeptideAtlasiP90747
PRIDEiP90747

Expressioni

Gene expression databases

BgeeiWBGene00007514 Expressed in 5 organ(s), highest expression level in adult organism

Interactioni

Protein-protein interaction databases

STRINGi6239.C10C6.6.1

Structurei

3D structure databases

ProteinModelPortaliP90747
SMRiP90747
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0209 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00550000075064
HOGENOMiHOG000199432
InParanoidiP90747
KOiK14950
OMAiQVSTFAI
OrthoDBiEOG091G00UD
PhylomeDBiP90747

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
TIGR01657 P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

P90747-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVDQLVETI IPYNLRSIAT HLYVPPFTII TAIWTYVWLN IFGYEEYYEL
60 70 80 90 100
GMLGYAAIFV ILALVLLFCH WMMPVRCFLM CSKQEDVRIA SHVCVIPTQN
110 120 130 140 150
NGWPELVKLM RTTRDKQTKL WFEFQRVHYT WDEESREFQT KTLDTAKPMV
160 170 180 190 200
FFQKSHGFEV EEHVKDAKYL LGDNKTEMIV PQFLEMFIER ATAPFFVFQV
210 220 230 240 250
FCVGLWCLED MWYYSLFTLF MLMTFEATLV KQQMKNMSEI RNMGNKTYMI
260 270 280 290 300
NVLRGKKWQK IKIEELVAGD IVSIGRGAEE ECVPCDLLLL RGPCIVDESM
310 320 330 340 350
LTGESVPQMK EPIEDVEKDK IFDIETDSRL HVIFGGTKIV QHTAPGKAAE
360 370 380 390 400
GMVKSPDGNC ICYVIRTGFN TSQGKLLRTI MFGVKKATAN NLETFCFILF
410 420 430 440 450
LLIFAIAAAA YLWIKGSVDE TRSKYKLFLE CTLILTSVIP PELPIELSLA
460 470 480 490 500
VNSSLMALQK LGIFCTEPFR IPFAGKVDIC CFDKTGTLTT DNLVVEGVAL
510 520 530 540 550
NNQKEGMIRN AEDLPHESLQ VLASCHSLVR FEEDLVGDPL EKACLSWCGW
560 570 580 590 600
NLTKGDAVMP PKTAAKGISG IKIFHRYHFS SAMKRMTVVA GYQSPGTSDT
610 620 630 640 650
TFIVAVKGAP EVLRNMYADL PSDYDETYTR LTRQGSRVLA MGIRKLGETR
660 670 680 690 700
VGELRDKKRE NFENDLAFAG FVVISCPLKS DTKTMIREIM DSSHVVAMIT
710 720 730 740 750
GDNPLTACHV SKVLKFTKKS LPTLVLDEPA DGVDWMWKSV DGTIELPLKP
760 770 780 790 800
ETKNKMERKA FFNSHEFCLT GSAFHHLVHN EHTFLRELIL HVKVFARMAP
810 820 830 840 850
KQKERIINEL KSLGKVTLMC GDGTNDVGAL KHANVGVALL TNPYDAEKAA
860 870 880 890 900
EKEKEKKAKI EEARSLVRSG AQLPQRPGAP GAPPAANAAR RDAPPGARAR
910 920 930 940 950
APLPPMANAA QARLDNLMKE LEEEEKAQVI KLGDASIAAP FTSKYTSIAS
960 970 980 990 1000
ICHVIKQGRC TLVTTLQMFK ILALNALVSA YSLSALYLDG VKFSDTQATI
1010 1020 1030 1040 1050
QGLLLAACFL FISKSKPLKT LSRQRPMANI FNAYTLLTVT LQFIVHFSCL
1060 1070 1080 1090 1100
LYIVGLAHEA NTEKAPVDLE AKFTPNILNT TVYIISMALQ VCTFAVNYRG
1110 1120 1130 1140 1150
RPFMESLFEN KAMLYSIMFS GGAVFTLASG QATDLMIQFE LVVLPEALRN
1160 1170
ALLMCVTADL VICYIIDRGL NFLLGDMF
Length:1,178
Mass (Da):131,973
Last modified:January 17, 2003 - v3
Checksum:i8394E3E368BE0488
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83217 Genomic DNA Translation: CAB05683.2
PIRiT19187
RefSeqiNP_502165.2, NM_069764.5
UniGeneiCel.17131

Genome annotation databases

EnsemblMetazoaiC10C6.6; C10C6.6; WBGene00007514
GeneIDi178070
KEGGicel:CELE_C10C6.6
UCSCiC10C6.6 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83217 Genomic DNA Translation: CAB05683.2
PIRiT19187
RefSeqiNP_502165.2, NM_069764.5
UniGeneiCel.17131

3D structure databases

ProteinModelPortaliP90747
SMRiP90747
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C10C6.6.1

Proteomic databases

EPDiP90747
PaxDbiP90747
PeptideAtlasiP90747
PRIDEiP90747

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC10C6.6; C10C6.6; WBGene00007514
GeneIDi178070
KEGGicel:CELE_C10C6.6
UCSCiC10C6.6 c. elegans

Organism-specific databases

CTDi178070
WormBaseiC10C6.6 ; CE30858 ; WBGene00007514 ; catp-8

Phylogenomic databases

eggNOGiKOG0209 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00550000075064
HOGENOMiHOG000199432
InParanoidiP90747
KOiK14950
OMAiQVSTFAI
OrthoDBiEOG091G00UD
PhylomeDBiP90747

Enzyme and pathway databases

ReactomeiR-CEL-936837 Ion transport by P-type ATPases

Miscellaneous databases

PROiPR:P90747

Gene expression databases

BgeeiWBGene00007514 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006544 P-type_TPase_V
IPR001757 P_typ_ATPase
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01494 ATPase_P-type, 2 hits
TIGR01657 P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAT131_CAEEL
AccessioniPrimary (citable) accession number: P90747
Secondary accession number(s): O02620
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 17, 2003
Last modified: November 7, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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