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Entry version 112 (02 Jun 2021)
Sequence version 1 (01 May 1997)
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Protein

Sodium channel protein

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Sodium channelUniRule annotationARBA annotation, Voltage-gated channelUniRule annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.10.2, the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAplysia californica (California sea hare)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6500 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiidaAplysioideaAplysiidaeAplysia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei130 – 157HelicalUniRule annotationAdd BLAST28
Transmembranei201 – 220HelicalUniRule annotationAdd BLAST20
Transmembranei232 – 254HelicalUniRule annotationAdd BLAST23
Transmembranei260 – 279HelicalUniRule annotationAdd BLAST20
Transmembranei397 – 423HelicalUniRule annotationAdd BLAST27
Transmembranei746 – 770HelicalUniRule annotationAdd BLAST25
Transmembranei791 – 814HelicalUniRule annotationAdd BLAST24
Transmembranei820 – 844HelicalUniRule annotationAdd BLAST25
Transmembranei865 – 893HelicalUniRule annotationAdd BLAST29
Transmembranei958 – 984HelicalUniRule annotationAdd BLAST27
Transmembranei1179 – 1197HelicalUniRule annotationAdd BLAST19
Transmembranei1218 – 1240HelicalUniRule annotationAdd BLAST23
Transmembranei1246 – 1265HelicalUniRule annotationAdd BLAST20
Transmembranei1303 – 1325HelicalUniRule annotationAdd BLAST23
Transmembranei1415 – 1441HelicalUniRule annotationAdd BLAST27
Transmembranei1502 – 1519HelicalUniRule annotationAdd BLAST18
Transmembranei1531 – 1549HelicalUniRule annotationAdd BLAST19
Transmembranei1561 – 1581HelicalUniRule annotationAdd BLAST21
Transmembranei1618 – 1648HelicalUniRule annotationAdd BLAST31
Transmembranei1668 – 1689HelicalUniRule annotationAdd BLAST22
Transmembranei1710 – 1732HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini137 – 430Ion_transInterPro annotationAdd BLAST294
Domaini483 – 623Na_trans_cytoplInterPro annotationAdd BLAST141
Domaini755 – 990Ion_transInterPro annotationAdd BLAST236
Domaini998 – 1169Na_trans_assocInterPro annotationAdd BLAST172
Domaini1177 – 1451Ion_transInterPro annotationAdd BLAST275
Domaini1502 – 1742Ion_transInterPro annotationAdd BLAST241

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 77DisorderedSequence analysisAdd BLAST48
Regioni430 – 541DisorderedSequence analysisAdd BLAST112
Regioni588 – 636DisorderedSequence analysisAdd BLAST49
Regioni649 – 688DisorderedSequence analysisAdd BLAST40
Regioni1824 – 1851DisorderedSequence analysisAdd BLAST28
Regioni1870 – 1993DisorderedSequence analysisAdd BLAST124

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 77Basic and acidic residuesSequence analysisAdd BLAST25
Compositional biasi430 – 451Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi453 – 468Polar residuesSequence analysisAdd BLAST16
Compositional biasi472 – 487Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi488 – 510Polar residuesSequence analysisAdd BLAST23
Compositional biasi596 – 636Polar residuesSequence analysisAdd BLAST41
Compositional biasi1830 – 1851Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi1880 – 1894Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1916 – 1966Basic and acidic residuesSequence analysisAdd BLAST51

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
56920at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13433, Na_channel_gate, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005821, Ion_trans_dom
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037, PTHR10037, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00170, NACHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P90670-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDHELAEWTP FRLFTRESLF TIDRRIAEEE AAKHAEKAPP ESDDDDEELD
60 70 80 90 100
EPSHHEENLK PNPKLEAGRK LPPSLEDYPR EYVGKPLEDL DEFYHNQKTF
110 120 130 140 150
VVLKKDKAIF RFSATDAIFL LSPFNPIRRI AIYILVHPIF SLLVMMTILV
160 170 180 190 200
NCVFMAITSY TPPAFVEHIF LGIYTVEAVV KVLSRGFVLK PFTYLRDPWN
210 220 230 240 250
WLDFFVISIA YMTMTVKSFG NLQALRTFRV LRALKTISVI PGLKTIVGAL
260 270 280 290 300
LEAVRRLRDV MILTVFVLSI FALIGMQLYS GALRQKCVLN PVPELGTNIT
310 320 330 340 350
HDEWNDWVNN ESHWQKDFYD EWQVCGNGTG AGKCGNGTIN GTAEWLCLPN
360 370 380 390 400
IGQNPNHDFT SFDNFGMALL CAFRLMTQDF WESLYHLVLR AVGSAHCLYF
410 420 430 440 450
VLVILLGSFY LVNLILAIVA MSYDETQKQD QADAEEEAAE RQEEEARKEA
460 470 480 490 500
LSIMTKSPSN SSWNNDFEAG VRTAGDKAEE KERLSLTSDH SATSAHLKPS
510 520 530 540 550
RLNQKRHSLS LPGSPYIHRR NSRGSQYSWR KPVPTAKRSP YCPDRQPLVH
560 570 580 590 600
HTLENLPLPF ADDSAAVTPS SEDLCNFSFI RNMPNGRRFS FASQRRPDGT
610 620 630 640 650
GRSGSRRSSF ASNHSRASRT SRGSGQGDRT KTQTLLNFKK GKVPDVVLDK
660 670 680 690 700
SKLDDDQDSV SSGGSGHCPE KDKASESNPF LSHSPGGPNV EMKDVMVLKD
710 720 730 740 750
ILDQASGHRR SFVSMTSIHQ RTMKDIMWKY FCTWDCHPNF QKLQRLVSLF
760 770 780 790 800
IMDAFVDLFI TICILVNTAF MAMEHYDMED DLKAVSNAAN LVFTAIFAVE
810 820 830 840 850
AFLKILALSP VIYFKDGWNI FDSIIVALSL MELSMTKLPG LSVLRAFRLL
860 870 880 890 900
RVFKLAKSWP TLNMLIAIVG RTMGALGNLI IVLGIIIFIF AVMGQQLFSS
910 920 930 940 950
DYKTYEREID AWGNVTINKD KMPRWNFNDF LHSFMIVFRV LCGEWIESMW
960 970 980 990 1000
GCYLVSGWAC VPFFLLTYVV GNLVVLNLFL ALLLSSFGSE SLQRSESDDE
1010 1020 1030 1040 1050
PSKIAEAIDR FKRFGNWVKV KIIVCIKVKL QRQKNWRPPP TTGQSEVNGK
1060 1070 1080 1090 1100
DPAVVDGTVV SMEKTPDDFP DGPCCPAQAA ICSAKKDLKS PSGSHSNSGS
1110 1120 1130 1140 1150
SHCSSCSSLS ESAQTKKIDL EADHEINEVE IVYVKEPDDC FCYMCTKRCP
1160 1170 1180 1190 1200
WCVKVEKSKI GRAWWAVRCF FYRLTENKYF DSFIIAMILA SSCALALEDA
1210 1220 1230 1240 1250
YLHEKPILKE ILEYLDKVFT AIFIIEMLIK WLAFGFKTYF TDAWCWLDFT
1260 1270 1280 1290 1300
IVMLSIVMLV ADLTASEEGG GSMSWMKSMR TLRALRPLRA VSRWEGMRVV
1310 1320 1330 1340 1350
VNALFKAIPS ICNVLLVCLV FWLIFGIMGV QLFNGKFHAC RDEKGDKYPR
1360 1370 1380 1390 1400
EEVPNKTVCI DKGYNWTNAQ INFDHVLSAY LALFQVATYK GWIDIMNNAI
1410 1420 1430 1440 1450
DSTEIGQQPS REENVIMYLF FVLFIVFCSF FTLNLFIGVI IENFNSQKKK
1460 1470 1480 1490 1500
AGGSLEMFMT EDQKKYYNAM KRMQSKSPQK SIPRPKYKLA GLIFDITTDQ
1510 1520 1530 1540 1550
KFDIAIMVII ILNMLTMMFE HHGMSAQMKN ILGIFNLIFI TIFTAECVLK
1560 1570 1580 1590 1600
LIGLRWYYFK IPWNVFDFVV VVLSILASSL SEFEDSFFIS PTLLRVIRVF
1610 1620 1630 1640 1650
RVGRVLRLVK SAKGIRTLLF SMAVSLPALF NIGLLLGLIM FIYAIMGMNF
1660 1670 1680 1690 1700
FMGAEQKYGL DDAFNFDTFL RSFILLFQMC TSAGWSDVLN GLIARCAPEG
1710 1720 1730 1740 1750
TCKDYNVATI YLATYLVVSF LVVVNMYIAV ILENFSQATE DEQQGLTPDD
1760 1770 1780 1790 1800
FDMYYEKWEK YDPKASKYIP LDQLSDFVDY LEEPLRLPKP NHFILVKLDI
1810 1820 1830 1840 1850
PICENDRCYC RDILDALTKN FLGTGETSDI PQKETDKEKE EYKPISSTLR
1860 1870 1880 1890 1900
RQKEHYAARI IQKAYRNFKG ITFGDGTGSS GKDEDTRSSK SDDDNDDDNG
1910 1920 1930 1940 1950
GDGRGGGMNG TRGGRRHGAE NGEKTKDRDG SKRDGKDSPS KDSNDDSSQQ
1960 1970 1980 1990
AQDKPKETED EEQRLQDSGI VIVNETDADP KTVELGPDSG VVA
Length:1,993
Mass (Da):225,898
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33E174B9BF07E1A7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U66915 mRNA Translation: AAC47457.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T30902

NCBI Reference Sequences

More...
RefSeqi
NP_001191637.1, NM_001204708.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100533425

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66915 mRNA Translation: AAC47457.1
PIRiT30902
RefSeqiNP_001191637.1, NM_001204708.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.1.10.2, the voltage-gated ion channel (vic) superfamily

Genome annotation databases

GeneIDi100533425

Phylogenomic databases

OrthoDBi56920at2759

Family and domain databases

CDDicd13433, Na_channel_gate, 1 hit
Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR001696, Na_channel_asu
IPR044564, Na_chnl_inactivation_gate
IPR010526, Na_trans_assoc
IPR024583, Na_trans_cytopl
IPR043203, VGCC_Ca_Na
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR10037, PTHR10037, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 4 hits
PF06512, Na_trans_assoc, 1 hit
PF11933, Na_trans_cytopl, 1 hit
PRINTSiPR00170, NACHANNEL

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP90670_APLCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P90670
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: June 2, 2021
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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