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Entry version 69 (05 Jun 2019)
Sequence version 1 (01 May 1997)
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Protein

Major viral transcription factor ICP4 homolog

Gene

ICP4

Organism
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi319 – 547By similarityAdd BLAST229

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major viral transcription factor ICP4 homolog
Alternative name(s):
Alpha-4 protein
Infected cell protein 4
Transcriptional activator IE175
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ICP4
Synonyms:IE175
ORF Names:RS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10315 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001874 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003854601 – 1318Major viral transcription factor ICP4 homologAdd BLAST1318

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ADP-ribosylated.By similarity
The long stretch of Ser is a major site of phosphorylation. Only the phosphorylated forms are capable of interacting with beta or gamma genes.By similarity

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P90493

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Keywords - Developmental stagei

Early protein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with transcriptional regulator ICP27; this interaction is required for proper incorporation of ICP4 into virions.

Interacts with host TBP and host TAF1; these interactions help the stabilization of the pre-initiation complex on specific promoters.

Interacts with host GTF2B.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P90493

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 10Poly-Lys4
Compositional biasi11 – 15Poly-Thr5
Compositional biasi163 – 175Poly-AspAdd BLAST13
Compositional biasi210 – 216His-rich7
Compositional biasi217 – 220Poly-Arg4
Compositional biasi259 – 265Poly-Asp7
Compositional biasi378 – 381Poly-Pro4
Compositional biasi567 – 571Poly-Ala5
Compositional biasi614 – 620Poly-Asp7
Compositional biasi621 – 628Poly-Gly8
Compositional biasi752 – 757Poly-Ala6
Compositional biasi1310 – 1313Poly-Asp4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal and C-terminal domains are required for the transcriptional activation function of ICP4.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae ICP4 family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005205 Herpes_ICP4_C
IPR005206 Herpes_ICP4_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03585 Herpes_ICP4_C, 1 hit
PF03584 Herpes_ICP4_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P90493-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEQRKKKK TTTTTQGRGA EVAMADEDGG RLRAAAETTG GPGSPDPADG
60 70 80 90 100
PPPTPNPDRR PAARPGFGWH GGPEENEDEA DDAAADADAD EAAPASGEAV
110 120 130 140 150
DEPAADGVVS PRQLALLASM VDEAVRTIPS PPPERDGAQE EAARSPSPPR
160 170 180 190 200
TPSMRADYGE ENDDDDDDDD DDDRDAGRWV RGPETTSAVR GAYPDPMASL
210 220 230 240 250
SPRPPAPRRH HHHHHHRRRR APRRRSAASD SSKSGSSSSA SSASSSASSS
260 270 280 290 300
SSASASSSDD DDDDDAARAP ASAADHAAGG TLGADDEEAG VPARAPGAAP
310 320 330 340 350
RPSPPRAEPA PARTPAATAG RLERRRARAA VAGRDATGRF TAGRPRRVEL
360 370 380 390 400
DADAASGAFY ARYRDGYVSG EPWPGAGPPP PGRVLYGGLG DSRPGLWGAP
410 420 430 440 450
EAEEARARFE ASGAPAPVWA PELGDAAQQY ALITRLLYTP DAEAMGWLQN
460 470 480 490 500
PRVAPGDVAL DQACFRISGA ARNSSSFISG SVARAVPHLG YAMAAGRFGW
510 520 530 540 550
GLAHVAAAVA MSRRYDRAQK GFLLTSLRRA YAPLLARENA ALTGARTPDD
560 570 580 590 600
GGDANRHDGD DARGKPAAAA APLPSAAASP ADERAVPAGY GAAGVLAALG
610 620 630 640 650
RLSAAPASAP AGADDDDDDD GAGGGGGGRR AEAGRVAVEC LAACRGILEA
660 670 680 690 700
LAEGFDGDLA AVPGLAGARP AAPPRPGPAG AAAPPHADAP RLRAWLRELR
710 720 730 740 750
FVRDALVLMR LRGDLRVAGG SEAAVAAVRA VSLVAGALGP ALPRSPRLLS
760 770 780 790 800
SAAAAAADLL FQNQSLRPLL ADTVAAADSL AAPASAPREA RKRKSPAPAR
810 820 830 840 850
APPGGAPRPP KKSRADAPRP AAAPPAGAAP PAPPTPPPRP PRPAALTRRP
860 870 880 890 900
AEGPDPQGGW RRQPPGPSHT PAPSAAALEA YCAPRAVAEL TDHPLFPAPW
910 920 930 940 950
RPALMFDPRA LASLAARCAA PPPGGAPAAF GPLRASGPLR RAAAWMRQVP
960 970 980 990 1000
DPEDVRVVIL YSPLPGEDLA AGRAGGGPPP EWSAERGGLS CLLAALGNRL
1010 1020 1030 1040 1050
CGPATAAWAG NWTGAPDVSA LGAQGVLLLS TRDLAFAGAV EFLGLLAGAC
1060 1070 1080 1090 1100
DRRLIVVNAV RAADWPADGP VVSRQHAYLA CEVLPAVQCA VRWPAARDLR
1110 1120 1130 1140 1150
RTVLASGRVF GPGVFARVEA AHARLYPDAP PLRLCRGANV RYRVRTRFGP
1160 1170 1180 1190 1200
DTLVPMSPRE YRRAVLPALD GRAAASGAGD AMAPGAPDFC EDEAHSHRAC
1210 1220 1230 1240 1250
ARWGLGAPLR PVYVALGRDA VRGGPAELRG PRREFCARAL LEPDGDAPPL
1260 1270 1280 1290 1300
VLRDDADAGP PPQIRWASAA GRAGTVLAAA GGGVEVVGTA AGLATPPRRE
1310
PVDMDAELED DDDGLFGE
Length:1,318
Mass (Da):135,104
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C0EEAF76897D7B2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z86099 Genomic DNA Translation: CAB06701.1
Z86099 Genomic DNA Translation: CAB06707.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z86099 Genomic DNA Translation: CAB06701.1
Z86099 Genomic DNA Translation: CAB06707.1

3D structure databases

SMRiP90493
ModBaseiSearch...

Proteomic databases

PRIDEiP90493

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR005205 Herpes_ICP4_C
IPR005206 Herpes_ICP4_N
PfamiView protein in Pfam
PF03585 Herpes_ICP4_C, 1 hit
PF03584 Herpes_ICP4_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICP4_HHV2H
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P90493
Secondary accession number(s): O12645, O12646
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 1, 1997
Last modified: June 5, 2019
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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