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Protein

Apoptosis regulator Bcl-2 homolog

Gene

vBCL2

Organism
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the protection against apoptosis mediated by cytotoxic cells during the immune response to acute and persistent viral infection. Contributes therefore to latency establishment. Plays also a role in the inhibition of host starvation-induced autophagy which ultimately contributes to the viral chronic infection.5 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host apoptosis by viral BCL2-like protein, Inhibition of host autophagy by virus, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis regulator Bcl-2 homolog
Short name:
vBcl-2
Alternative name(s):
Protein M11
Gene namesi
Name:vBCL2
OrganismiMurid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68)
Taxonomic identifieri33708 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiApodemus sylvaticus (European woodmouse) [TaxID: 10129]
Proteomesi
  • UP000099649 Componenti: Genome
  • UP000175018 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004432261 – 171Apoptosis regulator Bcl-2 homologAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29Interchain (with C-104)
Disulfide bondi104Interchain (with C-29)

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Interacts with host BECN1; this interaction inhibits host autophagy. Interacts with host BAK1 and BAX.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BECN1Q144574EBI-8849581,EBI-949378From Homo sapiens.

Protein-protein interaction databases

DIPiDIP-47218N
IntActiP89884, 13 interactors
MINTiP89884

Structurei

Secondary structure

1171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 22Combined sources16
Helixi27 – 29Combined sources3
Helixi32 – 55Combined sources24
Turni61 – 63Combined sources3
Helixi64 – 66Combined sources3
Helixi67 – 80Combined sources14
Helixi85 – 101Combined sources17
Beta strandi105 – 107Combined sources3
Helixi110 – 125Combined sources16
Helixi128 – 131Combined sources4

3D structure databases

SMRiP89884
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR029450 Apo_reg_M11
IPR036834 Blc2-like_sf
PfamiView protein in Pfam
PF15286 Bcl-2_3, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit

Sequencei

Sequence statusi: Complete.

P89884-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHKKSGTYW ATLITAFLKT VSKVEELDCV DSAVLVDVSK IITLTQEFRR
60 70 80 90 100
HYDSVYRADY GPALKNWKRD LSKLFTSLFV DVINSGRIVG FFDVGRYVCE
110 120 130 140 150
EVLCPGSWTE DHELLNDCMT HFFIENNLMN HFPLEDIFLA QRKFQTTGFT
160 170
FLLHALAKVL PRIYSGNVIY V
Length:171
Mass (Da):19,743
Last modified:May 1, 1997 - v1
Checksum:i43937262635E3446
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91858 Genomic DNA Translation: AAB50016.1
U97553 Genomic DNA Translation: AAB66423.1
AF105037 Genomic DNA Translation: AAF19336.1
GQ421301 Genomic DNA Translation: ACV65512.1
RefSeqiNP_044912.1, NC_001826.2

Genome annotation databases

GeneIDi1497180
KEGGivg:1497180

Similar proteinsi

Entry informationi

Entry nameiARBH_MHV68
AccessioniPrimary (citable) accession number: P89884
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2018
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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