UniProtKB - P89102 (SEC5_YEAST)
Protein
Exocyst complex component SEC5
Gene
SEC5
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Miscellaneous
Present with 3400 molecules/cell in log phase SD medium.1 Publication
GO - Biological processi
- endoplasmic reticulum inheritance Source: SGD
- exocyst assembly Source: SGD
- exocytosis Source: SGD
- Golgi to plasma membrane transport Source: SGD
- protein transport Source: UniProtKB-KW
- vesicle-mediated transport Source: GO_Central
- vesicle tethering involved in exocytosis Source: SGD
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-SCE-264876, Insulin processing |
Protein family/group databases
TCDBi | 1.F.2.1.1, the octameric exocyst (exocyst) family |
Names & Taxonomyi
Protein namesi | Recommended name: Exocyst complex component SEC5 |
Gene namesi | Name:SEC5 Ordered Locus Names:YDR166C ORF Names:YD8358.20C, YD9489.01C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000002573, SEC5 |
VEuPathDBi | FungiDB:YDR166C |
Subcellular locationi
Other locations
- cell periphery Source: SGD
- cellular bud neck Source: SGD
- cellular bud tip Source: SGD
- exocyst Source: SGD
- incipient cellular bud site Source: SGD
- mating projection tip Source: SGD
- prospore membrane Source: SGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000118924 | 1 – 971 | Exocyst complex component SEC5Add BLAST | 971 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 184 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P89102 |
PaxDbi | P89102 |
PRIDEi | P89102 |
PTM databases
iPTMneti | P89102 |
Interactioni
Subunit structurei
The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 32217, 124 interactors |
ComplexPortali | CPX-1890, Exocyst |
DIPi | DIP-2579N |
IntActi | P89102, 15 interactors |
MINTi | P89102 |
STRINGi | 4932.YDR166C |
Miscellaneous databases
RNActi | P89102, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 123 – 182 | Sequence analysisAdd BLAST | 60 |
Sequence similaritiesi
Belongs to the SEC5 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2347, Eukaryota |
GeneTreei | ENSGT00390000010872 |
HOGENOMi | CLU_339546_0_0_1 |
InParanoidi | P89102 |
OMAi | WEKLAFW |
Family and domain databases
InterProi | View protein in InterPro IPR029175, EXOC2/Sec5 IPR039481, EXOC2/Sec5_N_dom |
PANTHERi | PTHR13043, PTHR13043, 1 hit |
Pfami | View protein in Pfam PF15469, Sec5, 1 hit |
i Sequence
Sequence statusi: Complete.
P89102-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRFQIGDEQ LLRFYQLKTI NPTHSWAQDS SKLNNEEATS NELGVETSFD
60 70 80 90 100
ILKDFKYGNQ ISIDKESRAY LNDESLSYIR DPLNGQEMSK ELQHLPNDSM
110 120 130 140 150
RLNYLVNSKQ FNVKAFLRDM HKQDSFNDLN NSLDRLDSDI QDQSIHLKQL
160 170 180 190 200
VGKNFTKYVK IKNKLDQIYK EFDEKTNEKN QCDSPKENQI NVESLNKKVD
210 220 230 240 250
EVIRTTTFKL KPLMDNYQKI LNYQATKKFI ELNKFYFNLP KSLKRCLTNN
260 270 280 290 300
DFNEFIIEYS KGLTLRRRFN QSSDASQSLV IKRIWTQIEN LLVTYKDLIW
310 320 330 340 350
NSLINSNFNI DQPQETILSL FSKLLNLENF INNNQRESES GNKNTTSSSN
360 370 380 390 400
ENPILRWMSI KMNGFQNELN ELSGHMISKI IHSQRLILQN NTNQDKSQGC
410 420 430 440 450
VELSYYLKIN QLFQIISDTG KDSEGLKSTV EPNKVNTISG TSYLNLNCQP
460 470 480 490 500
SSQGLTDSPT IIEMWLLILK YINDLWKICD QFIEFWEHIE KFLDGTYQNS
510 520 530 540 550
IINEKRKENI LIGDSNIIES YQKSLILKEE QINEVRLKGE EFITSVSQNL
560 570 580 590 600
ISFFTSSQSS LPSSLKDSTG DITRSNKDSG SPLDYGFIPP NCNGLSCLRY
610 620 630 640 650
LPKIVEPILK FSTELAQLNI TTNGITICRN TLSTIINRCV GAISSTKLRD
660 670 680 690 700
ISNFYQLENW QVYETVTFSS KSQDSSKNLT FEYGVTQFPE IVTSFQEVSI
710 720 730 740 750
KTTRDLLFAY EKLPIINGIS VVSYPSKQLL TGIEIQQIIS MEAVLEAILK
760 770 780 790 800
NAAKDKDNPR NSHTILTLTN LQYFRECAFP NILQYFDDAF EWNLASKNLE
810 820 830 840 850
LFSLLSKMES SIFGNYLSDL KINLRDTLEE KFHEINWPMY TSNSFRVGDY
860 870 880 890 900
IIEALMILIV VHSECFRIGP QLIHKILIET QIFIARYLFE AFKPYVGNLS
910 920 930 940 950
NDGSLQIIVD LEFFQKVMGP LLEKDTEATL RACLQNCFQN DTNRLQKCIN
960 970
EINPIVSANL KRTAIQFAAF S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08788 Genomic DNA Translation: CAA70040.1 Z47813 Genomic DNA Translation: CAA87797.1 Z50046 Genomic DNA Translation: CAA90386.1 BK006938 Genomic DNA Translation: DAA12006.1 |
PIRi | S50912 |
RefSeqi | NP_010450.3, NM_001180473.3 |
Genome annotation databases
EnsemblFungii | YDR166C_mRNA; YDR166C; YDR166C |
GeneIDi | 851744 |
KEGGi | sce:YDR166C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08788 Genomic DNA Translation: CAA70040.1 Z47813 Genomic DNA Translation: CAA87797.1 Z50046 Genomic DNA Translation: CAA90386.1 BK006938 Genomic DNA Translation: DAA12006.1 |
PIRi | S50912 |
RefSeqi | NP_010450.3, NM_001180473.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5YFP | electron microscopy | 4.40 | B | 1-971 | [»] | |
6VKL | electron microscopy | 4.40 | B | 1-971 | [»] | |
SMRi | P89102 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32217, 124 interactors |
ComplexPortali | CPX-1890, Exocyst |
DIPi | DIP-2579N |
IntActi | P89102, 15 interactors |
MINTi | P89102 |
STRINGi | 4932.YDR166C |
Protein family/group databases
TCDBi | 1.F.2.1.1, the octameric exocyst (exocyst) family |
PTM databases
iPTMneti | P89102 |
Proteomic databases
MaxQBi | P89102 |
PaxDbi | P89102 |
PRIDEi | P89102 |
Genome annotation databases
EnsemblFungii | YDR166C_mRNA; YDR166C; YDR166C |
GeneIDi | 851744 |
KEGGi | sce:YDR166C |
Organism-specific databases
SGDi | S000002573, SEC5 |
VEuPathDBi | FungiDB:YDR166C |
Phylogenomic databases
eggNOGi | KOG2347, Eukaryota |
GeneTreei | ENSGT00390000010872 |
HOGENOMi | CLU_339546_0_0_1 |
InParanoidi | P89102 |
OMAi | WEKLAFW |
Enzyme and pathway databases
Reactomei | R-SCE-264876, Insulin processing |
Miscellaneous databases
PROi | PR:P89102 |
RNActi | P89102, protein |
Family and domain databases
InterProi | View protein in InterPro IPR029175, EXOC2/Sec5 IPR039481, EXOC2/Sec5_N_dom |
PANTHERi | PTHR13043, PTHR13043, 1 hit |
Pfami | View protein in Pfam PF15469, Sec5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SEC5_YEAST | |
Accessioni | P89102Primary (citable) accession number: P89102 Secondary accession number(s): D6VSE6, Q03775, Q04128 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast chromosome IV
Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names