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Protein

E4-ORF1

Gene

E4

Organism
Human adenovirus D serotype 9 (HAdV-9) (Human adenovirus 9)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in virus oncogenecity in animals. Binds and sequesters human MUPP1/MPDZ protein in the cytoplasm, preventing it from playing a role in cellular proliferation regulation. Induces cell transformation, probably by inactivating MPDZ protein.1 Publication

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHost-virus interaction, Nucleotide metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
E4-ORF1 (EC:3.6.1.23)
Alternative name(s):
Early E4 14.0 kDa protein
ORF1
Probable dUTPase E4 ORF1
Gene namesi
Name:E4
OrganismiHuman adenovirus D serotype 9 (HAdV-9) (Human adenovirus 9)
Taxonomic identifieri10527 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeMastadenovirusHuman mastadenovirus D
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000118285 Componenti: Genome

Subcellular locationi

  • Host cytoplasm 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi34 – 41FHIPPHGV → IHIPPQGA: Complete loss of transformation. 1 Publication8
Mutagenesisi89L → Q: Complete loss of transformation. 1 Publication1
Mutagenesisi91F → S: Complete loss of transformation. 1 Publication1
Mutagenesisi122A → D: Partial loss of transformation. Complete loss of binding to MPDZ. Localizes aberrantly in the nucleus. 2 Publications1
Mutagenesisi123 – 125TLV → P: Complete loss of transformation. Complete loss of binding to MPDZ. Localizes aberrantly in the nucleus. 2 Publications3
Mutagenesisi124L → P: Partial loss of transformation. Partial loss of binding to MPDZ. Localizes aberrantly in the nucleus. 1 Publication1

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002217841 – 125E4-ORF1Add BLAST125

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Binds to human MPDZ.

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg1Q626964EBI-7401124,EBI-389325From Rattus norvegicus.

Protein-protein interaction databases

DIPiDIP-44835N
ELMiP89079
IntActiP89079, 3 interactors
MINTiP89079

Structurei

3D structure databases

ProteinModelPortaliP89079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi122 – 125PDZ-bindingSequence analysis4

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit

Sequencei

Sequence statusi: Complete.

P89079-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESLYAFID SPGGIAPVQE GTSNRYTFFC PESFHIPPHG VVLLHLKVSV
60 70 80 90 100
LVPTGYQGRF MALNDYHARD ILTQSDVIFA GRRQELTVLL FNHTDRFLYV
110 120
RKGHPVGTLL LERVIFPSVK IATLV
Length:125
Mass (Da):14,041
Last modified:May 1, 1997 - v1
Checksum:i75792A75E484BC09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82508 Genomic DNA Translation: AAB37504.1
AJ854486 Genomic DNA Translation: CAI05991.1

Similar proteinsi

Entry informationi

Entry nameiE4OR1_ADE09
AccessioniPrimary (citable) accession number: P89079
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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