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UniProtKB - P88917 (P88917_HHV8)

Entry version 59 (12 Aug 2020)
Sequence version 1 (01 May 1997)
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Protein

Major capsid protein

Gene

MCP

Organism
Human herpesvirus 8 type M
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCPUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman herpesvirus 8 type MImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri435895 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiViruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus ›

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Capsid protein, Host nucleusUniRule annotation, T=16 icosahedral capsid proteinARBA annotation, Virion

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons.

Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2.

Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus.

Interacts with capsid vertex component 2/CVC2.

Interacts with the small capsomere-interacting protein/SCP.

UniRule annotation

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P88917, 1 interactor

Molecular INTeraction database

More...MINTi		P88917

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P88917

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_04016, HSV_MCP, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000912, Herpes_MCP
IPR023233, Herpes_MCP_upper_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03122, Herpes_MCP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00235, HSVCAPSIDMCP

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103417, SSF103417, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P88917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEATLEQRPF PYLATEANLL TQIKESAADG LFKSFQLLLG KDAREGSVRF 
        60         70         80         90        100
EALLGVYTNV VEFVKFLETA LAAACVNTEF KDLRRMIDGK IQFKISMPTI 
       110        120        130        140        150
AHGDGRRPNK QRQYIVMKAC NKHHIGAEIE LAAADIELLF AEKETPLDFT 
       160        170        180        190        200
EYAGAIKTIT SALQFGMDAL ERGLVDTVLA VKLRHAPPVF ILKTLGDPVY 
       210        220        230        240        250
SERGLKKAVK SDMVSMFKAH LIEHSFFLDK AELMTRGKQY VLTMLSDMLA 
       260        270        280        290        300
AVCEDTVFKG VSTYTTASGQ QVAGVLETTD SVMRRLMNLL GQVESAMSGP 
       310        320        330        340        350
AAYASYVVRG ANLVTAVSYG RAMRNFEQFM ARIVDHPNAL PSVEGDKAAL 
       360        370        380        390        400
ADGHDEIQRT RIAASLVKIG DKFVAIESLQ RMYNETQFPC PLNRRIQYTY 
       410        420        430        440        450
FFPVGLHLPV PRYSTSVSVR GVESPAIQST ETWVVNKNNV PLCFGYQNAL 
       460        470        480        490        500
KSICHPRMHN PTQSAQALNQ AFPDPDGGHG YGLRYEQTPN MNLFRTFHQY 
       510        520        530        540        550
YMGKNVAFVP DVAQKALVTT EDLLHPTSHR LLRLEVHPFF DFFVHPCPGA 
       560        570        580        590        600
RGSYRATHRT MVGNIPQPLA PREFQESRGA QFDAVTNMTH VIDQLTIDVI 
       610        620        630        640        650
QETAFDPAYP LFCYVIEAMI HGQEEKFVMN MPLIALVIQT YWVNSGKLAF 
       660        670        680        690        700
VNSYHMVRFI CTHMGNGSIP KEAHGHYRKI LGELIALEQA LLKLAGHETV 
       710        720        730        740        750
GRTPITHLVS ALLDPHLLPP FAYHDVFTDL MQKSSRQPII KIGDQNYDNP 
       760        770        780        790        800
QNRATFINLR GRMEDLVNNL VNIYQTRVNE DHDERHVLDV APLDENDYNP 
       810        820        830        840        850
VLEKLFYYVL MPVCSNGHMC GMGVDYQNVA LTLTYNGPVF ADVVNAQDDI 
       860        870        880        890        900
LLHLENGTLK DILQAGDIRP TVDMIRVLCT SFLTCPFVTQ AARVITKRDP 
       910        920        930        940        950
AQSFATHEYG KDVAQTVLVN GFGAFAVADR SREAAETMFY PVPFNKLYAD 
       960        970        980        990       1000
PLVAATLHPL LANYVTRLPN QRNAVVFNVP SNLMAEYEEW HKSPVAAYAA 
      1010       1020       1030       1040       1050
SCQATPGAIS AMVSMHQKLS APSFICQAKH RMHPGFAMTV VRTDEVLAEH 
      1060       1070       1080       1090       1100
ILYCSRASTS MFVGLPSVVR REVRSDAVTF EITHEIASLH TALGYSSVIA 
      1110       1120       1130       1140       1150
PAHVAAITTD MGVHCQDLFM IFPGDAYQDR QLHDYIKMKA GVQTGSPGNR 
      1160       1170       1180       1190       1200
MDHVGYTAGV PRCENLPGLS HGQLATCEII PTPVTSDVAY FQTPSNPRGR 
      1210       1220       1230       1240       1250
AACVVSCDAY SNESAERLLY DHSIPDPAYE CRSTNNPWAS QRGSLGDVLY 
      1260       1270       1280       1290       1300
NITFRQTALP GMYSPCRQFF HKEDIMRYNR GLYTLVNEYS ARLAGAPATS 
      1310       1320       1330       1340       1350
TTDLQYVVVN GTDVFLDQPC HMLQEAYPTL AASHRVMLDE YMSNKQTHAP 
      1360       1370 
VHMGQYLIEE VAPMKRLLKL GNKVVY
Length:1,376
Mass (Da):153,420
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i413E0CD4A7BB98D2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U75698 Genomic DNA Translation: AAC57106.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75698 Genomic DNA Translation: AAC57106.1

3D structure databases

SMRiP88917
ModBaseiSearch...

Protein-protein interaction databases

IntActiP88917, 1 interactor
MINTiP88917

Family and domain databases

HAMAPiMF_04016, HSV_MCP, 1 hit
InterProiView protein in InterPro
IPR000912, Herpes_MCP
IPR023233, Herpes_MCP_upper_sf
PfamiView protein in Pfam
PF03122, Herpes_MCP, 1 hit
PRINTSiPR00235, HSVCAPSIDMCP
SUPFAMiSSF103417, SSF103417, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP88917_HHV8
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P88917
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: August 12, 2020
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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