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Protein
Submitted name:

Cathepsin D

Gene
N/A
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96PROSITE-ProRule annotation1
Active sitei283PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl proteasePROSITE-ProRule annotation, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.009

Names & Taxonomyi

Protein namesi
Submitted name:
Cathepsin DImported (EC:3.4.23.5Imported)
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)Imported
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501267791016 – 398Sequence analysisAdd BLAST383

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliP87370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 395Peptidase A1InterPro annotationAdd BLAST318

Sequence similaritiesi

Belongs to the peptidase A1 family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG000482

Family and domain databases

CDDicd05490 Cathepsin_D2, 1 hit
Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033144 Cathepsin_D
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PTHR13683:SF554 PTHR13683:SF554, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 2 hits
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

P87370-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLYLCLFA ALALASDALV RIPLRKFRSI RRTLTDSGRA AEELLAGQEH
60 70 80 90 100
TKYNNLGFPS SSNGPTPETL KNFMDAQYYG EIGLGTPVQT FTVVFDTGSS
110 120 130 140 150
NLWVPSVHCS FTDIACLLHH KYNGAKSSTY VKNGTAFAIQ YGSGSLSGYL
160 170 180 190 200
SQDTCTIGGL SIEDQGFGEA IKQPGVAFIA AKFDGILGMA YPRISVDGVA
210 220 230 240 250
PPFDNIMSQK KVEQNVFSFY LNRNPDSEPG GELLLGGTDP KYYSGDFQYL
260 270 280 290 300
DVSRQAYWQI HMDGMGVGSQ LSLCKGGCEA IVDTGTSLIT GPAAEVKALQ
310 320 330 340 350
RAIGATPLIQ GEYMVNCDKI PTMPVITFNL GGQSYSLTAE QYVLKESQAG
360 370 380 390
KTICLSGFMG LDIPAPAGPL WILGDVFIGQ YYTVFDRDNN RVGFAKSK
Length:398
Mass (Da):42,973
Last modified:May 1, 1997 - v1
Checksum:i23C94FB3F5EC99D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90321 mRNA Translation: AAC60301.1
RefSeqiNP_001118183.1, NM_001124711.1
UniGeneiOmy.11433

Genome annotation databases

GeneIDi100136761

Similar proteinsi

Entry informationi

Entry nameiP87370_ONCMY
AccessioniPrimary (citable) accession number: P87370
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 1997
Last sequence update: May 1, 1997
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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