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Entry version 103 (26 Feb 2020)
Sequence version 2 (06 Dec 2002)
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Protein

Vacuolar protein sorting-associated protein 13a

Gene

vps13a

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in recycling of membrane proteins between an endocytic compartment and the TGN.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 13a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:vps13a
Synonyms:vps1301
ORF Names:SPBC21C3.01c, SPBC31F10.18c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC21C3.01c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001168771 – 3011Vacuolar protein sorting-associated protein 13aAdd BLAST3011

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P87319

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P87319

PRoteomics IDEntifications database

More...
PRIDEi
P87319

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4896.SPBC21C3.01c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P87319

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS13 family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000135_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P87319

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P87319

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009543 SHR-BD
IPR026847 VPS13
IPR031645 VPS13_C
IPR017148 VPS13_fungi
IPR031642 VPS13_mid_rpt
IPR026854 VPS13_N
IPR031646 VPS13_N2

The PANTHER Classification System

More...
PANTHERi
PTHR16166 PTHR16166, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12624 Chorein_N, 1 hit
PF06650 SHR-BD, 1 hit
PF16908 VPS13, 1 hit
PF16909 VPS13_C, 1 hit
PF16910 VPS13_mid_rpt, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037235 VPS13_fungi, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P87319-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLEGLVAGLL NKILGSYVDN LDTKQLNIGV WGGHVSLHNL RIKPEALDKL
60 70 80 90 100
GIPIEITSGL IGTFTLEIPW SNLRNKSLTI NIEDIYLSIH PQAKNSLTRD
110 120 130 140 150
ELEQSQQALK QEQLDSFEIL RKNFRETLEE SSSNPNISRK QSFIEYLIAK
160 170 180 190 200
LTDNIQIYIE RIHLRFEDNL SDLEKPYSLG LTLYSLRVTS TDASFTEYLL
210 220 230 240 250
STDPIPSSCI HKIITVDYFS IYWISKCEIS KCTTTEDIFS YLKNLIPSAE
260 270 280 290 300
KSPAYNYILK PLRATAHVVL FRHPTDQIMQ LRGKLSVEEI SITLSDHMYY
310 320 330 340 350
SLLGVIDYFR VVMKQQYYLQ YRPKSTPKEK PLEWFKYAIL VVKDSVHESR
360 370 380 390 400
YHWTWKYFKR RRDDRIAYMH IIRKRYLNEQ ISKEEIDLQK KIEKRNSTYD
410 420 430 440 450
LIKYRSRVHT SLIEERNSIY LKPKTSAAHG LYDWFSGYIR KPQSQDEDTL
460 470 480 490 500
ASTDKTAADL TDQEQKEFFS AIEWSGQLYP DTVNLDPDMC MANVEVSIAK
510 520 530 540 550
GSFVIQSHIN GRVIPLIKQR FESFATECFI RPQSLKLKVS LKDLDMFDGI
560 570 580 590 600
TNPELEPARV IFAKPSVEES ESLQKIPEAY RTHLFFLLLD TKPVYKASST
610 620 630 640 650
LIVHLRTLVI IYNRVCIESL LAFFVPPRTK IEHVSEWGYS AAAKVMTLAR
660 670 680 690 700
QTRASLDYAL EMHKTSDMTI DLQAPLIVVR EECTDLKSPT LFLDVGRALV
710 720 730 740 750
HTQLVDDAII DKFRKLQSKK INNEQLKQLE NLMYDKFTIS LFNVRCLIGP
760 770 780 790 800
DYETGWRCLP KGCDYHILKE CSLDINFEIS ILQKATNLTK FKVSSHMKHA
810 820 830 840 850
EIMFSDVQYK VFINMMSNIL PTLPVAEIPF TYQQFLDAVK PPPFFDAPDN
860 870 880 890 900
FQITHTSLGS HANENTAAQF MAQQIFAFYF KVDYAICSLY RRSENYLIPV
910 920 930 940 950
VRAFTEFYID LVVRKFDYLV TSKLNDLVIK EFTYPSSLCD NVLVRSSPSP
960 970 980 990 1000
KNNFDDTVFI SYTSIDYDSP ELDSVYEGVR TTIAVVLSDL ILNVEPTGFS
1010 1020 1030 1040 1050
FVYDFIRATF TSLNDEYMIG EDPELTRKIS PVEGIIPEDA NVRFDNVDIF
1060 1070 1080 1090 1100
LYDCDQHFST VCLYSANMHM EFREKFFLQA RFYDLEVKNH MKSNNPPKTI
1110 1120 1130 1140 1150
VKIDDNDLFI FKYESYDIPK DISKPTCDCV YDISFGSLTF YFQKSYFNAI
1160 1170 1180 1190 1200
YDFLLKLKRF QELFSSIRYA IYYKLYGNKV SLTYPKFELR IKHPKVYFDD
1210 1220 1230 1240 1250
VLDEERNCRM QLIVKPQSFY AFSKCPIVEK NSKKSIFSCE ITKVEFHTAV
1260 1270 1280 1290 1300
PSSSHHDVLM EENNVHLDLT YDANYTTGAY VFKATGDLDP VILNMCQSHH
1310 1320 1330 1340 1350
VIFWDLIDVA TTFARVDSSF YTSENLRREL DKAFDRSGTA AKLKHPKKTV
1360 1370 1380 1390 1400
VETLDILTTF NLPEIRLNVH TDDFWIHGGD LTQLHSILSF FGFSLDYNFY
1410 1420 1430 1440 1450
SSGRCYAEFS IDSIQLKDCN PQDNVVFLDV LEYSENHNRL VNGCLEYDSQ
1460 1470 1480 1490 1500
NPRYNLVLDI DSPKIFVNLN YLYSIWSIFV HWHRAYYSHL DYLTEVEYFI
1510 1520 1530 1540 1550
MGNPNQNACG EESYWYYRIT FVDMTLLFFR NVSDANLYSL PMFFGELLIT
1560 1570 1580 1590 1600
QQSIFAVTAN NMKINACPLS ETANISNQLA DPFGFRYTYS QHTVNKIQII
1610 1620 1630 1640 1650
TNITLDFDSF VLRTTVNDFL FLQTILRKIY NFYYALYDVP TTDVELLKRT
1660 1670 1680 1690 1700
KDDQLATNPD FLQLSVDTGQ PSSVFGIRIC KEEFLLTVDG IRLLVISQLH
1710 1720 1730 1740 1750
DLPLLNINIK PFQVDLNDWS SELNSNAHLE LFMNFYNFSN SHWEPFLEPW
1760 1770 1780 1790 1800
KVGVHISRNP NTSKTAVHVF SREKLDLVIT PQLIETLHFG FTKVISTPFP
1810 1820 1830 1840 1850
IEFKCDAPYR IHNYTGHAVS VWADFENAAD SCVRHLENNE ETDWKFEEWR
1860 1870 1880 1890 1900
QMQDVVKQDQ DRSYIGFHFE NSKWESLRHV RVNRVGEHIY PLISYDQDEL
1910 1920 1930 1940 1950
KHYMVVDVNL GEDYIKHITL RSPLLLINET QMEIDVVFCD SDGIQRSQIY
1960 1970 1980 1990 2000
HMSPEESCSL PIETAYYYSI HIRPVSEFKF NWTSEAISWK DLVDNKQSLV
2010 2020 2030 2040 2050
TCQHSDNTFS TPACRFAANA ELKSQTISNH YPFMHITISA LLEVKNLLPI
2060 2070 2080 2090 2100
DLNIRIIDKD QEGVWMSNVG IGECAYVHSI NISHVLLLQA ESSESHYLPS
2110 2120 2130 2140 2150
SLATIITNDS AQERDEYMTI TLQGGRKTRL GLSYTEKYPG IYHIEIFSPY
2160 2170 2180 2190 2200
IIINKSGSFL FVGPKNDYNR ISFSSASLSS GEDGKVVPCM FSYSHNYGSR
2210 2220 2230 2240 2250
RCRLRADNSN WSEPVSFDAI GSVFEVELPS KEDHNKVYRL GIFVETGPDG
2260 2270 2280 2290 2300
YSKTNIVTIT SRFIVRNKTR WSLVIAEPYN DFIAEIAPEG EEFLTYLRKH
2310 2320 2330 2340 2350
SHPMLKLSSS DCYLWSSSFY IEEIGSTHVR LMTSEGEKLL RLEIVIKNAT
2360 2370 2380 2390 2400
IFISIFEETG DWPYYIKNES GVLLKFWQVN PIDASEGKNN TALLKYHDIP
2410 2420 2430 2440 2450
PHSEVKYSWD YPCCANKEIA LCYGDQKCLT TLAEIGPLSP FKFTDASNNT
2460 2470 2480 2490 2500
KFISRDIVAN GLSKILILKD YDPSKAVRKP KIYSKVSTEE RDFNLEQFDS
2510 2520 2530 2540 2550
GIDLSVKFLL EGIGISLVER NTQELAYLTF HGINLFFTDS HLIRTFKLDV
2560 2570 2580 2590 2600
RWIQIDNQLY GGIYPIILYP SILSQEDTMN DNSLLPTFHS MVAVVKNDTY
2610 2620 2630 2640 2650
GVTYVKYATI LLQELTIEID EDFAFAALEY IKDSVPRSKR NTGKMFDDSL
2660 2670 2680 2690 2700
ELVPENLGND LKVYFEVLNL QPTEMHLSFV RTERINNTDG TVVSSHNPFV
2710 2720 2730 2740 2750
FFVNVLSMAI GNINDAPVRL NALLMDNAHV SLRRLFELVK NHYSQELLSQ
2760 2770 2780 2790 2800
VHKIVGSADF LGNPVGLFTT ITSGFADIFY EPFHGFILNE GSYELGIGFA
2810 2820 2830 2840 2850
KGTASFIKKA VFGITDSISK VTGTISRSLS VITLDPKFQS RRRAARIRNR
2860 2870 2880 2890 2900
PVHILYGVTA GAASLYTGVR SGVRGLALQP IIGARRNGLP GLVKGLGKGL
2910 2920 2930 2940 2950
VGFTTKPLVG LFDFASSISE GARNTTTVFD ERHIEKLRLS RLMSDDGVVY
2960 2970 2980 2990 3000
PFQLREALGQ YWLKHLDNGR YFKDFYKAHI IIENKVLVIL TNNRILFVQP
3010
QQLNCKKEIH L
Length:3,011
Mass (Da):346,899
Last modified:December 6, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EE431CD9AA42018
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10094.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T50345

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10094.1
PIRiT50345

3D structure databases

SMRiP87319
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4896.SPBC21C3.01c.1

Proteomic databases

MaxQBiP87319
PaxDbiP87319
PRIDEiP87319

Organism-specific databases

PomBaseiSPBC21C3.01c

Phylogenomic databases

HOGENOMiCLU_000135_0_0_1
InParanoidiP87319
PhylomeDBiP87319

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P87319

Family and domain databases

InterProiView protein in InterPro
IPR009543 SHR-BD
IPR026847 VPS13
IPR031645 VPS13_C
IPR017148 VPS13_fungi
IPR031642 VPS13_mid_rpt
IPR026854 VPS13_N
IPR031646 VPS13_N2
PANTHERiPTHR16166 PTHR16166, 1 hit
PfamiView protein in Pfam
PF12624 Chorein_N, 1 hit
PF06650 SHR-BD, 1 hit
PF16908 VPS13, 1 hit
PF16909 VPS13_C, 1 hit
PF16910 VPS13_mid_rpt, 1 hit
PIRSFiPIRSF037235 VPS13_fungi, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVP13A_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P87319
Secondary accession number(s): Q9P7M2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: February 26, 2020
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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