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Entry version 125 (16 Oct 2019)
Sequence version 1 (01 Jul 1997)
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Protein

Histone transcription regulator 3 homolog

Gene

hip3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Required for transcriptional silencing in the outer repeat (otr) region of centromeric repeats and the Tf2 long terminal repeat retrotransposons.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processChromosome partition, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone transcription regulator 3 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hip3
Synonyms:hir3
ORF Names:SPBC31F10.14c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC31F10.14c

Schizosaccharomyces pombe database

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PomBasei
SPBC31F10.14c hip3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002562031 – 1630Histone transcription regulator 3 homologAdd BLAST1630

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P87315

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P87315

PRoteomics IDEntifications database

More...
PRIDEi
P87315

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P87315

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hip1 and slm9.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
276759, 9 interactors

Protein interaction database and analysis system

More...
IntActi
P87315, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC31F10.14c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati8 – 42TPR 1Add BLAST35
Repeati1230 – 1263TPR 2Add BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HIR3 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P87315

Identification of Orthologs from Complete Genome Data

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OMAi
NVWKCDA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P87315

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033053 Hir3/CABIN1
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR15502 PTHR15502, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P87315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATFTPLNAA SEDLDKEKRT LEIRIEEAVQ IYQNALSAQK QGDDNAATKY
60 70 80 90 100
YDELLNVRIL RELPFTVNSN YKKNNALLLL HYLTRKNHGL FLLSKLQSLL
110 120 130 140 150
SLDPSTDPIP VYRDALLDFA IALACDYNDI ELWSFVAELA EKLEMPRIQR
160 170 180 190 200
FALESSFYTG YEPFDAERVF TNIDDLNPGK LISLQNLYNL LKKLGGIAEP
210 220 230 240 250
LPQLDLSISS LYTLPSFFPQ LPTPSFHRRS INLCPKIKKL QLSHDTLHGF
260 270 280 290 300
LDLVLYALQI NEKKTPTRGF PSTLIIHVHS LNLSTAESHD LESTDSELWS
310 320 330 340 350
EISDAGPDTN TINTAAKLSE PVYAKDIVPP PSDNLPKPQL LKRPIDDSDV
360 370 380 390 400
RISKRSRGRD LRTPSESNLF SLIASITSDI NEQIQKRFPD ATSPFSGESM
410 420 430 440 450
FREYSSIFED YHQLLVNFPS EGSIPDLDVS TDSAANGAFS KMILIDLAMH
460 470 480 490 500
SANRLEHMQV PDGYLLQLLS EVNSLNMVPA ELATFFVESM LRPRKLEPPF
510 520 530 540 550
YLQQCWGKIF KKKFTTICER IESTLHELVK ASLQTPEVFN ISQSLFELFL
560 570 580 590 600
DDYFLALKFS SNDQKDDNVS EIPTESLEYK KLRCLRWKSL TEQVVELQPS
610 620 630 640 650
CKSSSQRHLI IRNSWARNLL LRLTGCSSEA IVENFKQLRC LLQENSDSLE
660 670 680 690 700
LLNSQCMADL SVQVVDFELS KLQTVEFFNT LFMNTKNLDF NAVIKNLEPV
710 720 730 740 750
LSPENKFAED PQAKFISQFL EKTSTEFQIH LWYLLYQAYS SAHRPYNSLL
760 770 780 790 800
CAFQSLKIIL IRLCSSSFSI QDAGRRQAEL LGMLNFSSNL FRIIWQKLHE
810 820 830 840 850
QPDILSPCNE MTVIDCIRII LIYLRTFAIY VGIDEDISDQ RIPKPSNPEF
860 870 880 890 900
DSYAQTVKDS LMSGWCIFYT LFAHLLHYDF IKADAQKLLP QILTAIHSQY
910 920 930 940 950
SFRGYCSSSN QSFLELSQTE CQRLDAWENE NEILQCVCCR FNLIIGSEYY
960 970 980 990 1000
VPQSHQSDSV NLTSNDAIKI IPFILGFAVK RSHGWVMPRS DQKNALEIIC
1010 1020 1030 1040 1050
KVIRFPGENN ADVYFNKCAI KEFLERDISP QLTKMLLKSN DILGLREIGS
1060 1070 1080 1090 1100
KVVDDRVRGL YYAQSQVLFG YYRSRLKGSR CINDLLVIIK YFLLDLYLNP
1110 1120 1130 1140 1150
RRQDSWYTCS SVFSSLADEE LGWSAEQICL ADDVINEYRR KAILCNLMAL
1160 1170 1180 1190 1200
SLPFTQDKLF KANVYFDFAM NLYASARPPL EMAAFLPSET RVFSGASGLY
1210 1220 1230 1240 1250
NLSMKPIEVS KVIALAADYF GMSAELSNDW RALYMLGKAC RKCGDMENAL
1260 1270 1280 1290 1300
VHFEAAAALA PTKSGSGSQQ ALLIEPHYAL LSNLSKAAIE GSVEIVQILS
1310 1320 1330 1340 1350
YLRRIRHPPK DSGSLLEVKN EDVNIYKRNA LLFILKALAE MRILDKQSWH
1360 1370 1380 1390 1400
HRPTYRIAKI MEHLGNVQQA KEEMETLFSY KTSGKSLLNI WRTPNERPGR
1410 1420 1430 1440 1450
HFYYGATYSR YLLSLFYKTN DKVNFLQFLK RFRRSSSTIY EHRQIWLDIM
1460 1470 1480 1490 1500
IKYLEDLRLQ HSVKETQIND LPLVEFKYVY KEISLLDEQK LSLLHQVYEI
1510 1520 1530 1540 1550
RKLNNGLYPT IKVDDFLIDC FMSLYNEVKS SISPLDANIP NSPSTITAKP
1560 1570 1580 1590 1600
LNDEKAINNE NSVKQKTVIT RKDVVSKVLA LFRPHRETYY RETQNKILQK
1610 1620 1630
LASTSSSLVR SFTEDSSQAG ESPGIHEEIQ
Length:1,630
Mass (Da):186,701
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC641C83B1025E668
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10090.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40217

NCBI Reference Sequences

More...
RefSeqi
NP_596576.1, NM_001022497.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC31F10.14c.1; SPBC31F10.14c.1:pep; SPBC31F10.14c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540227

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC31F10.14c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10090.1
PIRiT40217
RefSeqiNP_596576.1, NM_001022497.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi276759, 9 interactors
IntActiP87315, 2 interactors
STRINGi4896.SPBC31F10.14c.1

PTM databases

iPTMnetiP87315

Proteomic databases

MaxQBiP87315
PaxDbiP87315
PRIDEiP87315

Genome annotation databases

EnsemblFungiiSPBC31F10.14c.1; SPBC31F10.14c.1:pep; SPBC31F10.14c
GeneIDi2540227
KEGGispo:SPBC31F10.14c

Organism-specific databases

EuPathDBiFungiDB:SPBC31F10.14c
PomBaseiSPBC31F10.14c hip3

Phylogenomic databases

InParanoidiP87315
OMAiNVWKCDA
PhylomeDBiP87315

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P87315

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR033053 Hir3/CABIN1
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR15502 PTHR15502, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIR3_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P87315
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 1, 1997
Last modified: October 16, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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