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UniProtKB - P87314 (HIR1_SCHPO)
Protein
Protein hir1
Gene
hip1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.
2 PublicationsGO - Biological processi
- chromatin organization Source: PomBase
- DNA replication-independent chromatin assembly Source: PomBase
- nucleosome organization Source: PomBase
- regulation of transcription, DNA-templated Source: InterPro
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Chromatin regulator, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein hir1Alternative name(s): Histone transcription regulator 1 homolog |
Gene namesi | Name:hip1 Synonyms:hir1 ORF Names:SPBC31F10.13c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPBC31F10.13c, hip1 |
VEuPathDBi | FungiDB:SPBC31F10.13c |
Subcellular locationi
Cytosol
- cytosol Source: PomBase
Nucleus
- nucleus Source: PomBase
Other locations
- chromatin Source: PomBase
- HIR complex Source: PomBase
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051023 | 1 – 932 | Protein hir1Add BLAST | 932 |
Proteomic databases
MaxQBi | P87314 |
PaxDbi | P87314 |
PTM databases
iPTMneti | P87314 |
Interactioni
Subunit structurei
Interacts with his3 and slm9.
2 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGRIDi | 276752, 299 interactors |
IntActi | P87314, 2 interactors |
STRINGi | 4896.SPBC31F10.13c.1 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P87314 |
SMRi | P87314 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 16 – 55 | WD 1Add BLAST | 40 | |
Repeati | 72 – 111 | WD 2Add BLAST | 40 | |
Repeati | 132 – 171 | WD 3Add BLAST | 40 | |
Repeati | 174 – 213 | WD 4Add BLAST | 40 | |
Repeati | 222 – 265 | WD 5Add BLAST | 44 | |
Repeati | 268 – 316 | WD 6Add BLAST | 49 | |
Repeati | 320 – 361 | WD 7Add BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 405 – 470 | DisorderedSequence analysisAdd BLAST | 66 | |
Regioni | 498 – 520 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 405 – 425 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 438 – 452 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the WD repeat HIR1 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0973, Eukaryota |
HOGENOMi | CLU_004372_3_0_1 |
InParanoidi | P87314 |
OMAi | RGSWDGD |
PhylomeDBi | P87314 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
IDEALi | IID50259 |
InterProi | View protein in InterPro IPR031120, HIR1 IPR011494, Hira IPR019015, HIRA_B_motif IPR011659, PD40 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR13831, PTHR13831, 1 hit |
Pfami | View protein in Pfam PF07569, Hira, 1 hit PF09453, HIRA_B, 1 hit PF07676, PD40, 1 hit PF00400, WD40, 4 hits |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
P87314-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKIKKIPWLG HFDDRGHRLS IFSIHIHPDG SRIATGGLDG TIRIWSTEAI
60 70 80 90 100
NRENENENEN EDLPKQLCCM STHTGTVTSV RFSPNGQYLA SGSDDRVVII
110 120 130 140 150
WHKEEAIPGL GSTFGSGEKH TENWRSYRRL LGHDNDIQDL CWSYDSQLVV
160 170 180 190 200
SVGLDSSIIV WNGTTFERLK RIEAHQSHVK GITFDPAGKY FATESDDRTI
210 220 230 240 250
KVWRVSDFSI EKTITGPFNN SPLSTYFRRP SWSPDGKHIA APNAMNGPVS
260 270 280 290 300
CVSIIERGTW TSEINLIGHE GPVEVTAFNP KLFRDKNDKL VCILACGGQD
310 320 330 340 350
RSLSIWSSAL PRPLLSCQNV FQKSIGDVCW SPDGLSLFLC SYDGNVLVCT
360 370 380 390 400
FEKEEFGDMV SDEEISKALA KYGHGRHGIV LPESAKQLEL EETAYAILKK
410 420 430 440 450
PSSLSTTDPT LVPQSSSTPK SAQKTPQKLP AFLPNRLTAE TVDTNKLTAS
460 470 480 490 500
KEQIASPKRP GPSDNGNEIP TKFVQKVTIT KEGKKRVAPQ LLTTLSATPS
510 520 530 540 550
TSRLASTQLQ HTGSSQLPPQ QFSQPINSLP KGGVPILIVG NKTKVNHEND
560 570 580 590 600
ESDQALQEEK IEEGLLKNYY SSLIDSSTSI SNINFEAPRY KTNIVHSLNN
610 620 630 640 650
EQKYVLEVKN GTSEKNPTRI VALENGNTKW MDYLPRPVIL VTGSIHFWSI
660 670 680 690 700
ACDDGSLHLY SLTGSRLLPP IMIESKASFL HCNNAYLLCI SSSGMVYAWN
710 720 730 740 750
VVNKTALFTA NSLAPILSRV SNNVTIENNS TDIPHVVIAS ISKEGVPSVT
760 770 780 790 800
LSTGETYVYS STMLCWQRIT EPWWAIGSRE WDSSGLLQSN TQTESQPLKI
810 820 830 840 850
YEHRTNNVLM DSGRGKLLQK MVADAITEEG YDDFETIVTI NHLENKIASA
860 870 880 890 900
RLLKLDDEFL VTSEVYVRLL MHHGLWQKLE EFLGELRTQT KCSIKLSGRE
910 920 930
VVAKMLVVLR QAVQTDNEFD RANKLIEKYA ST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB10089.1 AB027992 Genomic DNA Translation: BAA87296.1 |
PIRi | T40216 |
RefSeqi | NP_596575.1, NM_001022496.2 |
Genome annotation databases
EnsemblFungii | SPBC31F10.13c.1; SPBC31F10.13c.1:pep; SPBC31F10.13c |
GeneIDi | 2540219 |
KEGGi | spo:SPBC31F10.13c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329671 Genomic DNA Translation: CAB10089.1 AB027992 Genomic DNA Translation: BAA87296.1 |
PIRi | T40216 |
RefSeqi | NP_596575.1, NM_001022496.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Z34 | X-ray | 2.40 | C/D | 469-497 | [»] | |
AlphaFoldDBi | P87314 | |||||
SMRi | P87314 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 276752, 299 interactors |
IntActi | P87314, 2 interactors |
STRINGi | 4896.SPBC31F10.13c.1 |
PTM databases
iPTMneti | P87314 |
Proteomic databases
MaxQBi | P87314 |
PaxDbi | P87314 |
Genome annotation databases
EnsemblFungii | SPBC31F10.13c.1; SPBC31F10.13c.1:pep; SPBC31F10.13c |
GeneIDi | 2540219 |
KEGGi | spo:SPBC31F10.13c |
Organism-specific databases
PomBasei | SPBC31F10.13c, hip1 |
VEuPathDBi | FungiDB:SPBC31F10.13c |
Phylogenomic databases
eggNOGi | KOG0973, Eukaryota |
HOGENOMi | CLU_004372_3_0_1 |
InParanoidi | P87314 |
OMAi | RGSWDGD |
PhylomeDBi | P87314 |
Miscellaneous databases
PROi | PR:P87314 |
Family and domain databases
Gene3Di | 2.130.10.10, 2 hits |
IDEALi | IID50259 |
InterProi | View protein in InterPro IPR031120, HIR1 IPR011494, Hira IPR019015, HIRA_B_motif IPR011659, PD40 IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR13831, PTHR13831, 1 hit |
Pfami | View protein in Pfam PF07569, Hira, 1 hit PF09453, HIRA_B, 1 hit PF07676, PD40, 1 hit PF00400, WD40, 4 hits |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 1 hit PS50082, WD_REPEATS_2, 4 hits PS50294, WD_REPEATS_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HIR1_SCHPO | |
Accessioni | P87314Primary (citable) accession number: P87314 Secondary accession number(s): Q9US78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families