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Entry version 160 (25 May 2022)
Sequence version 1 (01 Jul 1997)
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Protein

Protein hir1

Gene

hip1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein hir1
Alternative name(s):
Histone transcription regulator 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hip1
Synonyms:hir1
ORF Names:SPBC31F10.13c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPBC31F10.13c, hip1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPBC31F10.13c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000510231 – 932Protein hir1Add BLAST932

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P87314

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P87314

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P87314

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with his3 and slm9.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
276752, 299 interactors

Protein interaction database and analysis system

More...
IntActi
P87314, 2 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPBC31F10.13c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1932
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P87314

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P87314

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati16 – 55WD 1Add BLAST40
Repeati72 – 111WD 2Add BLAST40
Repeati132 – 171WD 3Add BLAST40
Repeati174 – 213WD 4Add BLAST40
Repeati222 – 265WD 5Add BLAST44
Repeati268 – 316WD 6Add BLAST49
Repeati320 – 361WD 7Add BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni405 – 470DisorderedSequence analysisAdd BLAST66
Regioni498 – 520DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi405 – 425Polar residuesSequence analysisAdd BLAST21
Compositional biasi438 – 452Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat HIR1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0973, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004372_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P87314

Identification of Orthologs from Complete Genome Data

More...
OMAi
RGSWDGD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P87314

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID50259

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031120, HIR1
IPR011494, Hira
IPR019015, HIRA_B_motif
IPR011659, PD40
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13831, PTHR13831, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07569, Hira, 1 hit
PF09453, HIRA_B, 1 hit
PF07676, PD40, 1 hit
PF00400, WD40, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 4 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P87314-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIKKIPWLG HFDDRGHRLS IFSIHIHPDG SRIATGGLDG TIRIWSTEAI
60 70 80 90 100
NRENENENEN EDLPKQLCCM STHTGTVTSV RFSPNGQYLA SGSDDRVVII
110 120 130 140 150
WHKEEAIPGL GSTFGSGEKH TENWRSYRRL LGHDNDIQDL CWSYDSQLVV
160 170 180 190 200
SVGLDSSIIV WNGTTFERLK RIEAHQSHVK GITFDPAGKY FATESDDRTI
210 220 230 240 250
KVWRVSDFSI EKTITGPFNN SPLSTYFRRP SWSPDGKHIA APNAMNGPVS
260 270 280 290 300
CVSIIERGTW TSEINLIGHE GPVEVTAFNP KLFRDKNDKL VCILACGGQD
310 320 330 340 350
RSLSIWSSAL PRPLLSCQNV FQKSIGDVCW SPDGLSLFLC SYDGNVLVCT
360 370 380 390 400
FEKEEFGDMV SDEEISKALA KYGHGRHGIV LPESAKQLEL EETAYAILKK
410 420 430 440 450
PSSLSTTDPT LVPQSSSTPK SAQKTPQKLP AFLPNRLTAE TVDTNKLTAS
460 470 480 490 500
KEQIASPKRP GPSDNGNEIP TKFVQKVTIT KEGKKRVAPQ LLTTLSATPS
510 520 530 540 550
TSRLASTQLQ HTGSSQLPPQ QFSQPINSLP KGGVPILIVG NKTKVNHEND
560 570 580 590 600
ESDQALQEEK IEEGLLKNYY SSLIDSSTSI SNINFEAPRY KTNIVHSLNN
610 620 630 640 650
EQKYVLEVKN GTSEKNPTRI VALENGNTKW MDYLPRPVIL VTGSIHFWSI
660 670 680 690 700
ACDDGSLHLY SLTGSRLLPP IMIESKASFL HCNNAYLLCI SSSGMVYAWN
710 720 730 740 750
VVNKTALFTA NSLAPILSRV SNNVTIENNS TDIPHVVIAS ISKEGVPSVT
760 770 780 790 800
LSTGETYVYS STMLCWQRIT EPWWAIGSRE WDSSGLLQSN TQTESQPLKI
810 820 830 840 850
YEHRTNNVLM DSGRGKLLQK MVADAITEEG YDDFETIVTI NHLENKIASA
860 870 880 890 900
RLLKLDDEFL VTSEVYVRLL MHHGLWQKLE EFLGELRTQT KCSIKLSGRE
910 920 930
VVAKMLVVLR QAVQTDNEFD RANKLIEKYA ST
Length:932
Mass (Da):103,686
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i09D527CDB9003D3E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10089.1
AB027992 Genomic DNA Translation: BAA87296.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40216

NCBI Reference Sequences

More...
RefSeqi
NP_596575.1, NM_001022496.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC31F10.13c.1; SPBC31F10.13c.1:pep; SPBC31F10.13c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540219

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC31F10.13c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB10089.1
AB027992 Genomic DNA Translation: BAA87296.1
PIRiT40216
RefSeqiNP_596575.1, NM_001022496.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z34X-ray2.40C/D469-497[»]
AlphaFoldDBiP87314
SMRiP87314
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi276752, 299 interactors
IntActiP87314, 2 interactors
STRINGi4896.SPBC31F10.13c.1

PTM databases

iPTMnetiP87314

Proteomic databases

MaxQBiP87314
PaxDbiP87314

Genome annotation databases

EnsemblFungiiSPBC31F10.13c.1; SPBC31F10.13c.1:pep; SPBC31F10.13c
GeneIDi2540219
KEGGispo:SPBC31F10.13c

Organism-specific databases

PomBaseiSPBC31F10.13c, hip1
VEuPathDBiFungiDB:SPBC31F10.13c

Phylogenomic databases

eggNOGiKOG0973, Eukaryota
HOGENOMiCLU_004372_3_0_1
InParanoidiP87314
OMAiRGSWDGD
PhylomeDBiP87314

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P87314

Family and domain databases

Gene3Di2.130.10.10, 2 hits
IDEALiIID50259
InterProiView protein in InterPro
IPR031120, HIR1
IPR011494, Hira
IPR019015, HIRA_B_motif
IPR011659, PD40
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR13831, PTHR13831, 1 hit
PfamiView protein in Pfam
PF07569, Hira, 1 hit
PF09453, HIRA_B, 1 hit
PF07676, PD40, 1 hit
PF00400, WD40, 4 hits
SMARTiView protein in SMART
SM00320, WD40, 6 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 4 hits
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIR1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P87314
Secondary accession number(s): Q9US78
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: May 25, 2022
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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