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Protein

Translation initiation factor eIF-2B subunit epsilon

Gene

GCD6

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunit of the guanine nucleotide exchange factor for eIF-2.By similarity

GO - Molecular functioni

  • nucleotidyltransferase activity Source: InterPro
  • translation initiation factor activity Source: CGD

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor eIF-2B subunit epsilon
Alternative name(s):
GCD complex subunit GCD6
Guanine nucleotide exchange factor subunit GCD6
eIF-2B GDP-GTP exchange factor subunit epsilon
Gene namesi
Name:GCD6
Synonyms:TIF225
Ordered Locus Names:CAALFM_C108600CA
ORF Names:CaO19.407, CaO19.8037
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000183518 GCD6

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560761 – 732Translation initiation factor eIF-2B subunit epsilonAdd BLAST732

Proteomic databases

PRIDEiP87163

Interactioni

Subunit structurei

Complex of five different subunits; alpha (GCN3), beta (GCD7), gamma (GCD1), delta (GCD2) and epsilon (GCD6).By similarity

Structurei

3D structure databases

ProteinModelPortaliP87163
SMRiP87163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini559 – 726W2PROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Phylogenomic databases

InParanoidiP87163
KOiK03240
OrthoDBiEOG092C0S7J

Family and domain databases

CDDicd04197 eIF-2B_epsilon_N, 1 hit
Gene3Di1.25.40.180, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035543 eIF-2B_epsilon_N
IPR001451 Hexapep
IPR016021 MIF4-like_sf
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF00132 Hexapep, 2 hits
PF00483 NTP_transferase, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit

Sequencei

Sequence statusi: Complete.

P87163-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPKSKKQAA TQSKSKKSKD LVDERFQAIV LTDSFETRFM PLTAVHPRCL
60 70 80 90 100
LPLANVPLIE YTLEFLANAG VNEVYLMCSA HADQIQEYIE NSKWMGDNSP
110 120 130 140 150
FSVTTIMSIE SRSVGDTMRD LDNRGLIAGD FLLVSGDVVT NMDFSKALQF
160 170 180 190 200
HKQKKAQDKD HIATMVLNQA SPLHRTRSQI DPAAFVLDKE TNRCIFYQSI
210 220 230 240 250
PPVSGKKTCI SIDPELLEDF QGELQVRNDL IDCHVDICSP HVPQIFQENF
260 270 280 290 300
DYQYLRSDFL KGVLTSDLLK KTIYAYISKD SSEYAARVES WSTYDAISQD
310 320 330 340 350
ILARWCYPLV PDSNLVEGNS YSYELNNIYK EDKIILAQSC KIGTSTSIGR
360 370 380 390 400
NSSVGEGTQI KNSVIGRNCT IGKNVVIENS YIWDNAVIKD NSVLNRSIVA
410 420 430 440 450
ADAQIGNNVT LSPGSVIGFN VIIGDDKVIP HNVKIVETPI VTENEFGDFD
460 470 480 490 500
DESNSEDENE YEDGNAVPVL AVKDVELVGE TGKGFAYESE IESGDEDDEE
510 520 530 540 550
FVGNGTYSGI IYQMKSLNVS DDSIASVSNK KVKKHSHRRR LSMNSMISDN
560 570 580 590 600
GGAFESDEGE EEEDFGVEGL ATVTRAIENN HDIDTALLEL NTLRMSMNVT
610 620 630 640 650
YHDVRSVTTQ ALVNKIVDFI TTGTLTPQEA ATKIFTKWGI MFKRQVFSPE
660 670 680 690 700
EEVDLLNIVE EKSSVLDKAY NQIVLFLGVK SFYDMEVVEE ENILKWWNDG
710 720 730
ENDEVRTLAA KFITWLQEAD EEDSDEDDED SE
Length:732
Mass (Da):81,952
Last modified:March 15, 2017 - v3
Checksum:iA7C2E826A30376BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26498.1
U69674 Genomic DNA Translation: AAC49714.1
RefSeqiXP_711895.2, XM_706802.2

Genome annotation databases

EnsemblFungiiAOW26498; AOW26498; CAALFM_C108600CA
GeneIDi3646510
KEGGical:CAALFM_C108600CA

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26498.1
U69674 Genomic DNA Translation: AAC49714.1
RefSeqiXP_711895.2, XM_706802.2

3D structure databases

ProteinModelPortaliP87163
SMRiP87163
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP87163

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAOW26498; AOW26498; CAALFM_C108600CA
GeneIDi3646510
KEGGical:CAALFM_C108600CA

Organism-specific databases

CGDiCAL0000183518 GCD6

Phylogenomic databases

InParanoidiP87163
KOiK03240
OrthoDBiEOG092C0S7J

Miscellaneous databases

PROiPR:P87163

Family and domain databases

CDDicd04197 eIF-2B_epsilon_N, 1 hit
Gene3Di1.25.40.180, 1 hit
3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035543 eIF-2B_epsilon_N
IPR001451 Hexapep
IPR016021 MIF4-like_sf
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
IPR011004 Trimer_LpxA-like_sf
IPR003307 W2_domain
PfamiView protein in Pfam
PF00132 Hexapep, 2 hits
PF00483 NTP_transferase, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF51161 SSF51161, 1 hit
SSF53448 SSF53448, 2 hits
PROSITEiView protein in PROSITE
PS51363 W2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BE_CANAL
AccessioniPrimary (citable) accession number: P87163
Secondary accession number(s): A0A1D8PEB7, Q59QB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 15, 2017
Last modified: February 28, 2018
This is version 83 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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