Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 147 (16 Oct 2019)
Sequence version 1 (01 Jul 1997)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

DNA polymerase epsilon catalytic subunit A

Gene

pol2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA polymerase II participates in chromosomal DNA replication.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi2069ZincBy similarity1
Metal bindingi2072ZincBy similarity1
Metal bindingi2104ZincBy similarity1
Metal bindingi2107ZincBy similarity1
Metal bindingi2138Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2141Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2153Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi2155Iron-sulfur (4Fe-4S)By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri2069 – 2107CysA-typeBy similarityAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase
Biological processDNA replication
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SPO-174430 Telomere C-strand synthesis initiation
R-SPO-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-68952 DNA replication initiation
R-SPO-68962 Activation of the pre-replicative complex

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase epsilon catalytic subunit A (EC:2.7.7.7By similarity)
Alternative name(s):
DNA polymerase II subunit A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pol2
Synonyms:cdc20
ORF Names:SPBC25H2.13c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPBC25H2.13c

Schizosaccharomyces pombe database

More...
PomBasei
SPBC25H2.13c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000464641 – 2199DNA polymerase epsilon catalytic subunit AAdd BLAST2199

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P87154

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P87154

PRoteomics IDEntifications database

More...
PRIDEi
P87154

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P87154

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer. Consists of 4 subunits: pol2, dpb2, dpb3 and dpb4 (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
raf2O745602EBI-876811,EBI-904886

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
277153, 44 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2111 DNA polymerase epsilon heterotetramer

Database of interacting proteins

More...
DIPi
DIP-36490N

Protein interaction database and analysis system

More...
IntActi
P87154, 3 interactors

Molecular INTeraction database

More...
MINTi
P87154

STRING: functional protein association networks

More...
STRINGi
4896.SPBC25H2.13c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P87154

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2138 – 2155CysB motifBy similarityAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CysA-type zinc finger is required for PCNA-binding.By similarity
The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2069 – 2107CysA-typeBy similarityAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000196287

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P87154

KEGG Orthology (KO)

More...
KOi
K02324

Identification of Orthologs from Complete Genome Data

More...
OMAi
VYDLDMK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P87154

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.60, 1 hit
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR042087 DNA_pol_B_C
IPR013697 DNA_pol_e_suA_C
IPR029703 POL2
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10670 PTHR10670, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08490 DUF1744, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01159 DUF1744, 1 hit
SM00486 POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P87154-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLKTARGAS KYQFRKFNGN YNGKSKSNGR TFAKSTEEVG FNDPMKIVYK
60 70 80 90 100
KNEIDRMMGF DSYEGGQPRE AWLLNVHPTV IESTKGNSTL SAVDFYFIQD
110 120 130 140 150
DGDTFRCTIP YSPYFYIAAR EGKEALVDDY LKKKFVGLIK STTRIFKEDL
160 170 180 190 200
QLKNHIVGYQ KLYIKLVFDN LNDLQAVRKS LMSAVKANSS QQDAVDAYTN
210 220 230 240 250
LSSENLNGII ENAFEDPLNH VLDIREYDVP YHSRTLIDLN IRVGQWYTVS
260 270 280 290 300
YHEGHVQISL LASRIERAEP TIMAFDIETT KLPLKFPDSS FDKIMMISYM
310 320 330 340 350
IDGQGFLITN REIISQNIED FHYTPREEFE GPFIIFNEPD EVGLLHRFFK
360 370 380 390 400
HIRSAKPSVI VTYNGDFFDW PFVDARAAFH GLNLTEETGF FRDAEDEYKS
410 420 430 440 450
SYCSHMDAFR WVKRDSYLPQ GSQGLKAVTV SKLGYNPIEL DPELMTPYAS
460 470 480 490 500
EKPQVLAQYS VSDAVATYFL YMKYVHPFIF SLCNIIPLNP DEVLRKGTGT
510 520 530 540 550
LCETLLTVEA CTKNIILPNK HVDASQKFFD GHLLASETYV GGHVESLESG
560 570 580 590 600
VFRSDLPTNF NMDPKVYEEL ILQLDKALDF SLTVENNVNV DEIENYEEVR
610 620 630 640 650
DSILKKLSDL RDRPKRSEKP RIYHLDVASM YPNIMITNRL QPDSVKDESF
660 670 680 690 700
CATCDLNVPN KTCDRRMVWA WRGEYYPAKK GEYHMIYSAL QSERFPGPTP
710 720 730 740 750
FSPFRSFQEL SPSEQAAMVQ KRIADYSRKV YHRLYDNTVI ERETIICQKE
760 770 780 790 800
NSFYIDTVKS FRDRRYDFKG LQKKWVKQLA AIKEKGGLAE IEEAKKMVVL
810 820 830 840 850
YDSLQLAHKV ILNSFYGYVM RKGSRWYSIE MAGITCLTGA TIIQMARQIV
860 870 880 890 900
ERAGRPLELD TDGIWCILPE SFPENFEFKK KSGGKVFISY PCVMLNHLVH
910 920 930 940 950
EKFTNHQYSA LKDPEKLVYE TTSENSIFFE VDGPYRAMIL PASTEEGKNL
960 970 980 990 1000
KKRYAVFNFD GSLAELKGFE VKRRGELKLI KDFQSQIFKV FLKGDSLEEC
1010 1020 1030 1040 1050
YQEVAYVADT WLEILFTKGS NLTDDELIEL ISENRSMSKA LSEYGSQKST
1060 1070 1080 1090 1100
SITTARRLAD FLGDQMTKDK GLACRFIISA SPKGRPVAER AVPVAIFFAE
1110 1120 1130 1140 1150
ESVKRHFLRL WLKDNGLYDV DIRDIIDWDY YLKRLGSVVQ KLISIPAALQ
1160 1170 1180 1190 1200
RISNPVTRFP LPDWLQKRVA VLNSKYQQKK IDSIFSLAPT NPSTINNTKV
1210 1220 1230 1240 1250
TDIEDLGSVT HKDKRIVARV TKRKLLQQSG NSEAPVSFEV KPVSFMDGYS
1260 1270 1280 1290 1300
NWLKYAKKKW KYQKQVKLRR RHLIGFQSRQ FTNVLQSSAE VMFENLWHIL
1310 1320 1330 1340 1350
QIRETDVPGI LHAWVIIRNR LTSIRFIVNR KFFVCFKDET LPNVEIEGCL
1360 1370 1380 1390 1400
IEKSNAILPH GSTSDKLFLL EIPEKSYLTE KVSISMIFAH PSVSGIYETR
1410 1420 1430 1440 1450
IEPIERLILE MGSRKRFNNS VPGALGKGFE FGFESKMFTD PSDNDVSYLD
1460 1470 1480 1490 1500
GVEMNYLYAF HFSISNRFVF SLFMPHLKKV EAIIYDKLPG SDMSFPSISK
1510 1520 1530 1540 1550
IYEELRSKFD NLIKESSIEY PDTLSCNVIF SGNERKAYKL IDEKLLQYFS
1560 1570 1580 1590 1600
TKTKNSLLII ESSLPHILKA NVKQIEELPY IMIPRLESNI QSLSWKQHIA
1610 1620 1630 1640 1650
TKMIQHFLAI GSWLFHRIQL SRFSDIPLCN FESDDIQYSI DVVYSRKLKE
1660 1670 1680 1690 1700
HNIILWWNKG PTPDLGGIEK DSILQIASPK DPLEVNNPGA YSNACVDISL
1710 1720 1730 1740 1750
SNLALCSILN SALINDIEGI GDMAALNDNY MTAINDDLEE KLGIHDNIGL
1760 1770 1780 1790 1800
THSLPVLKAL VKTWWNEAAS GNNLADLIIQ HLARWISSSK SYLYSPLLSS
1810 1820 1830 1840 1850
HVEVIMRKTF LQLLSEIKRL GAHIIHASAN KILIKTSKLI VQNAVTYSNY
1860 1870 1880 1890 1900
LLKSIKTLPL FHFLDLNVTE YWDYLLWMDS VNYGGKMVAA NFSATNEEPQ
1910 1920 1930 1940 1950
TVVSWHIKSH LPPIIQPEFQ SWIVEFIEEV YKQKLEKSNT KVGFVRVKNN
1960 1970 1980 1990 2000
NADEDSEIVG SGILKSKLIH PLKRKVAQVR RCFQELQLDE NTREDLKFPK
2010 2020 2030 2040 2050
LPGSFLNYTD GALELVKSIC AVFELSHDLN LEVRFLKKSL LSLLQIQEFS
2060 2070 2080 2090 2100
TQAVFRYPSR RLSLDQIPCK QCGVHQDFDL CLHEHLWPTR DDMGTLVFSD
2110 2120 2130 2140 2150
GWSCSSCNLV YDRWVFEETL VDNLYHQLTL YQLQDLICSK CKTVKQWSLK
2160 2170 2180 2190
ERCSCSGEWV LQLSPTKFRE MLNVYQSVAD FYEFSILQNS VQSILSVLN
Length:2,199
Mass (Da):252,887
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA80A5D0865EEBC3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2116 – 2126FEETLVDNLYH → LRKLWWITYN in BAA13884 (PubMed:9501991).CuratedAdd BLAST11
Sequence conflicti2182Y → N in BAA13884 (PubMed:9501991).Curated1
Sequence conflicti2196 – 2199SVLN → FCAELTFLD in BAA13884 (PubMed:9501991).Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB08772.1
D89223 mRNA Translation: BAA13884.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40008
T43044

NCBI Reference Sequences

More...
RefSeqi
NP_596354.1, NM_001022274.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPBC25H2.13c.1; SPBC25H2.13c.1:pep; SPBC25H2.13c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2540627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPBC25H2.13c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA Translation: CAB08772.1
D89223 mRNA Translation: BAA13884.1
PIRiT40008
T43044
RefSeqiNP_596354.1, NM_001022274.2

3D structure databases

SMRiP87154
ModBaseiSearch...

Protein-protein interaction databases

BioGridi277153, 44 interactors
ComplexPortaliCPX-2111 DNA polymerase epsilon heterotetramer
DIPiDIP-36490N
IntActiP87154, 3 interactors
MINTiP87154
STRINGi4896.SPBC25H2.13c.1

PTM databases

iPTMnetiP87154

Proteomic databases

MaxQBiP87154
PaxDbiP87154
PRIDEiP87154

Genome annotation databases

EnsemblFungiiSPBC25H2.13c.1; SPBC25H2.13c.1:pep; SPBC25H2.13c
GeneIDi2540627
KEGGispo:SPBC25H2.13c

Organism-specific databases

EuPathDBiFungiDB:SPBC25H2.13c
PomBaseiSPBC25H2.13c

Phylogenomic databases

HOGENOMiHOG000196287
InParanoidiP87154
KOiK02324
OMAiVYDLDMK
PhylomeDBiP87154

Enzyme and pathway databases

ReactomeiR-SPO-110314 Recognition of DNA damage by PCNA-containing replication complex
R-SPO-174430 Telomere C-strand synthesis initiation
R-SPO-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-SPO-5656169 Termination of translesion DNA synthesis
R-SPO-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-SPO-5696400 Dual Incision in GG-NER
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SPO-68952 DNA replication initiation
R-SPO-68962 Activation of the pre-replicative complex

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P87154

Family and domain databases

Gene3Di1.10.132.60, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR042087 DNA_pol_B_C
IPR013697 DNA_pol_e_suA_C
IPR029703 POL2
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10670 PTHR10670, 1 hit
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08490 DUF1744, 1 hit
SMARTiView protein in SMART
SM01159 DUF1744, 1 hit
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOE_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P87154
Secondary accession number(s): P78873
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 1, 1997
Last modified: October 16, 2019
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again