UniProtKB - P87123 (RPB11_SCHPO)
Protein
DNA-directed RNA polymerase II subunit RPB11
Gene
rpb11
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).By similarity
GO - Molecular functioni
- DNA binding Source: InterPro
- protein dimerization activity Source: InterPro
- RNA polymerase II activity Source: InterPro
GO - Biological processi
- transcription by RNA polymerase II Source: PomBase
Keywordsi
Biological process | Transcription |
Enzyme and pathway databases
Reactomei | R-SPO-113418, Formation of the Early Elongation Complex R-SPO-5578749, Transcriptional regulation by small RNAs R-SPO-674695, RNA Polymerase II Pre-transcription Events R-SPO-6781823, Formation of TC-NER Pre-Incision Complex R-SPO-6782135, Dual incision in TC-NER R-SPO-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-SPO-6796648, TP53 Regulates Transcription of DNA Repair Genes R-SPO-6807505, RNA polymerase II transcribes snRNA genes R-SPO-72086, mRNA Capping R-SPO-73776, RNA Polymerase II Promoter Escape R-SPO-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-SPO-75953, RNA Polymerase II Transcription Initiation R-SPO-75955, RNA Polymerase II Transcription Elongation R-SPO-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-SPO-77075, RNA Pol II CTD phosphorylation and interaction with CE R-SPO-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-directed RNA polymerase II subunit RPB11Short name: RNA polymerase II subunit B11 Alternative name(s): DNA-directed RNA polymerase II 14.1 kDa polypeptide |
Gene namesi | Name:rpb11 ORF Names:SPAC3A12.07 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC3A12.07, rpb11 |
VEuPathDBi | FungiDB:SPAC3A12.07 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: PomBase
Nucleus
- nucleus Source: PomBase
- RNA polymerase II, core complex Source: PomBase
Keywords - Cellular componenti
DNA-directed RNA polymerase, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000149314 | 1 – 123 | DNA-directed RNA polymerase II subunit RPB11Add BLAST | 123 |
Proteomic databases
MaxQBi | P87123 |
PaxDbi | P87123 |
PTM databases
iPTMneti | P87123 |
Interactioni
Subunit structurei
Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 279544, 11 interactors |
IntActi | P87123, 2 interactors |
STRINGi | 4896.SPAC3A12.07.1 |
Structurei
3D structure databases
SMRi | P87123 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P87123 |
Family & Domainsi
Sequence similaritiesi
Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.Curated
Phylogenomic databases
eggNOGi | KOG4392, Eukaryota |
HOGENOMi | CLU_090381_2_1_1 |
InParanoidi | P87123 |
OMAi | HKFVLRI |
PhylomeDBi | P87123 |
Family and domain databases
CDDi | cd06926, RNAP_II_RPB11, 1 hit |
Gene3Di | 3.30.1360.10, 1 hit |
InterProi | View protein in InterPro IPR037685, RBP11 IPR036603, RBP11-like IPR009025, RBP11-like_dimer IPR008193, RNA_pol_Rpb11_13-16kDa_CS |
Pfami | View protein in Pfam PF13656, RNA_pol_L_2, 1 hit |
SUPFAMi | SSF55257, SSF55257, 1 hit |
PROSITEi | View protein in PROSITE PS01154, RNA_POL_L_13KD, 1 hit |
i Sequence
Sequence statusi: Complete.
P87123-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNQPERYELI ELMGLPKVTY ELDSKSPNAA VVTLEKEDHT LANMLANQLL
60 70 80 90 100
SDERVLFAGY KVPHPLNHNF ILRVQTVEDC SPKQVIVDAA KSLITHLEEI
110 120
KVNFMREWEL KMISVEGVEM EFS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89597 Genomic DNA Translation: BAA22806.1 D85902 mRNA Translation: BAA22801.1 AF027822 mRNA Translation: AAB92517.1 CU329670 Genomic DNA Translation: CAB08752.1 |
PIRi | T38675 |
RefSeqi | NP_593333.1, NM_001018765.2 |
Genome annotation databases
EnsemblFungii | SPAC3A12.07.1; SPAC3A12.07.1:pep; SPAC3A12.07 |
GeneIDi | 2543112 |
KEGGi | spo:SPAC3A12.07 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D89597 Genomic DNA Translation: BAA22806.1 D85902 mRNA Translation: BAA22801.1 AF027822 mRNA Translation: AAB92517.1 CU329670 Genomic DNA Translation: CAB08752.1 |
PIRi | T38675 |
RefSeqi | NP_593333.1, NM_001018765.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3H0G | X-ray | 3.65 | K/W | 1-123 | [»] | |
5U0S | electron microscopy | 7.80 | k | 1-123 | [»] | |
SMRi | P87123 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 279544, 11 interactors |
IntActi | P87123, 2 interactors |
STRINGi | 4896.SPAC3A12.07.1 |
PTM databases
iPTMneti | P87123 |
Proteomic databases
MaxQBi | P87123 |
PaxDbi | P87123 |
Genome annotation databases
EnsemblFungii | SPAC3A12.07.1; SPAC3A12.07.1:pep; SPAC3A12.07 |
GeneIDi | 2543112 |
KEGGi | spo:SPAC3A12.07 |
Organism-specific databases
PomBasei | SPAC3A12.07, rpb11 |
VEuPathDBi | FungiDB:SPAC3A12.07 |
Phylogenomic databases
eggNOGi | KOG4392, Eukaryota |
HOGENOMi | CLU_090381_2_1_1 |
InParanoidi | P87123 |
OMAi | HKFVLRI |
PhylomeDBi | P87123 |
Enzyme and pathway databases
Reactomei | R-SPO-113418, Formation of the Early Elongation Complex R-SPO-5578749, Transcriptional regulation by small RNAs R-SPO-674695, RNA Polymerase II Pre-transcription Events R-SPO-6781823, Formation of TC-NER Pre-Incision Complex R-SPO-6782135, Dual incision in TC-NER R-SPO-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER R-SPO-6796648, TP53 Regulates Transcription of DNA Repair Genes R-SPO-6807505, RNA polymerase II transcribes snRNA genes R-SPO-72086, mRNA Capping R-SPO-73776, RNA Polymerase II Promoter Escape R-SPO-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-SPO-75953, RNA Polymerase II Transcription Initiation R-SPO-75955, RNA Polymerase II Transcription Elongation R-SPO-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance R-SPO-77075, RNA Pol II CTD phosphorylation and interaction with CE R-SPO-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
EvolutionaryTracei | P87123 |
PROi | PR:P87123 |
Family and domain databases
CDDi | cd06926, RNAP_II_RPB11, 1 hit |
Gene3Di | 3.30.1360.10, 1 hit |
InterProi | View protein in InterPro IPR037685, RBP11 IPR036603, RBP11-like IPR009025, RBP11-like_dimer IPR008193, RNA_pol_Rpb11_13-16kDa_CS |
Pfami | View protein in Pfam PF13656, RNA_pol_L_2, 1 hit |
SUPFAMi | SSF55257, SSF55257, 1 hit |
PROSITEi | View protein in PROSITE PS01154, RNA_POL_L_13KD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RPB11_SCHPO | |
Accessioni | P87123Primary (citable) accession number: P87123 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 1, 1997 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families