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Protein

Transcription initiation factor TFIID subunit 2

Gene

taf2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by taf1), facilitation of DNA opening and initiation of transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-SPO-674695 RNA Polymerase II Pre-transcription Events
R-SPO-73776 RNA Polymerase II Promoter Escape
R-SPO-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SPO-75953 RNA Polymerase II Transcription Initiation
R-SPO-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 2
Alternative name(s):
TBP-associated factor 2
Gene namesi
Name:taf2
ORF Names:SPAC3A12.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3A12.05c
PomBaseiSPAC3A12.05c taf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003561811 – 1172Transcription initiation factor TFIID subunit 2Add BLAST1172

Proteomic databases

MaxQBiP87121
PaxDbiP87121
PRIDEiP87121

PTM databases

iPTMnetiP87121

Interactioni

Subunit structurei

Component of the DNA-binding general transcription factor complex TFIID.By similarity

Protein-protein interaction databases

BioGridi279539, 3 interactors
STRINGi4896.SPAC3A12.05c.1

Structurei

3D structure databases

ProteinModelPortaliP87121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF2 family.Curated

Phylogenomic databases

HOGENOMiHOG000157894
InParanoidiP87121
KOiK03128
OMAiSHGICPP
OrthoDBiEOG092C3V5H
PhylomeDBiP87121

Family and domain databases

InterProiView protein in InterPro
IPR037813 TAF2
PANTHERiPTHR15137 PTHR15137, 1 hit

Sequencei

Sequence statusi: Complete.

P87121-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQLVDVPAR GHQKVAIDID FASQTIIGRT DITVNPIDSN LQKIVLDCYQ
60 70 80 90 100
AEIHSVYVNG DLTKFSYSDA LKKLRIDEPN STVNQHHQLN LQYEALMNDL
110 120 130 140 150
GGINIFLSKP PGDELRPLIV SIDFSVHQPI FGITFVGIDP VDHRYPHVFT
160 170 180 190 200
NNSIIPYSTC SWLPCVDGIW ERSTWEFEIT LPKTLSSLMH REKTQPSDLN
210 220 230 240 250
NGANGVDGHD DNYENNRFDH QFNLSNEPDL LEDHDIEVIC CGDLLDQVTH
260 270 280 290 300
PKDMRKKTVY FSVTTPVAPN YIAFAAGPFK HINLTDFREP EDDDAMGSSA
310 320 330 340 350
IDITGYYLPK YAEEVENTCV FLYKAMDFFV REYGSYPFNS FKLCFVDETN
360 370 380 390 400
FPIISTPSLV ISSNSILYPK DSLDQIYDST KTLTWALASQ WIGVYLIPKA
410 420 430 440 450
WSDLWLIYGL SYYICGLFLK KLMGNNDYRF RLKKQVYRLL ELDIGKPPIS
460 470 480 490 500
QRNINIPIDP NTLDFIALKS PLVIHILERR LTKTGGSLGM SRVIPKLLLQ
510 520 530 540 550
VMSGDMLNGC LSTSHFLKTC EKASHMRLDV FAQQWIYGYG YPIFRVVQRF
560 570 580 590 600
NRKKMIIEMG IDQVQTKEAP RAPMSDKNFL SDAIRHLNNE SIPTGLPVFS
610 620 630 640 650
GPMTIRIHEA DGTPYEHVVE LKDSFTKLDI QYNTKYKRIS RNRSTKNVKR
660 670 680 690 700
DGDHNGDDSD YVIRSLGDVL QSDEDIERWH LYDYTKEEED TMATEAFEWI
710 720 730 740 750
RVDADFEWIC DLRVRQPEHM YVSQLQQDRD VVAQLETIRH FTSESFTVSQ
760 770 780 790 800
QVSTVLLRTL LDNRYYYGIR QEAARALARC AIPELDWVGY YHLRMAYLEK
810 820 830 840 850
FCFKDSTIPK SNDFSNITEY YVKCAMLESF PNIRDRKGVT PSSVKKLLLD
860 870 880 890 900
LLCYNDNANN EFSDAYFICL LIDSLVEGLI PRGETVQYAF SDPEHMEFVN
910 920 930 940 950
QVINEIDRYM RIDACMPSFK NIITCKSLKA KLRLAQTFHL EFGPKELLPY
960 970 980 990 1000
TQEGNYVLVR CIAFNLMLQA GALKYTPLIK YIFYILTNDL SPVVRRSLLY
1010 1020 1030 1040 1050
SVQDGLGALA RGGTKSDVAS EDLIVEEDIT KAVEKRIDIT SRASISGAIE
1060 1070 1080 1090 1100
ALRNDLGQNH DFATEIWNAI NNPKSDLLTK RNLLMICRVL YKAKSSLLVT
1110 1120 1130 1140 1150
LKIPSLIPRL RAIHLGKGKI VIKKAPLKQI TSKTKEKSTS PTPPSITINP
1160 1170
IKPKGPTLKI KLTNLRSTPP SH
Length:1,172
Mass (Da):133,909
Last modified:September 22, 2009 - v3
Checksum:iA05485B885286ED8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB08750.3
PIRiT38673
RefSeqiNP_593331.2, NM_001018762.3

Genome annotation databases

EnsemblFungiiSPAC3A12.05c.1; SPAC3A12.05c.1:pep; SPAC3A12.05c
GeneIDi2543107
KEGGispo:SPAC3A12.05c

Similar proteinsi

Entry informationi

Entry nameiTAF2_SCHPO
AccessioniPrimary (citable) accession number: P87121
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 22, 2009
Last modified: March 28, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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