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Entry version 125 (16 Oct 2019)
Sequence version 1 (01 Jul 1997)
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Protein

RNA cytidine acetyltransferase

Gene

nat10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N4-acetylcytidine (ac4C) at positions 1297 and 1815 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25402480). Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein tan1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (By similarity).UniRule annotationBy similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei465ATPUniRule annotation1
Binding sitei727Acetyl-CoAUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi285 – 294ATPUniRule annotation10

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processrRNA processing, tRNA processing
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA cytidine acetyltransferase1 PublicationUniRule annotation (EC:2.3.1.-UniRule annotation)
Alternative name(s):
18S rRNA cytosine acetyltransferaseUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nat101 PublicationUniRule annotation
ORF Names:SPAC20G8.09cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC20G8.09c

Schizosaccharomyces pombe database

More...
PomBasei
SPAC20G8.09c nat10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi285G → D: Completely lacks 18S rRNA acetylation and produces only trace amounts of the 40S small ribosomal subunit. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002158891 – 1033RNA cytidine acetyltransferaseAdd BLAST1033

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P87115

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P87115

PRoteomics IDEntifications database

More...
PRIDEi
P87115

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P87115

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P87115

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tan1.

UniRule annotation

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
278978, 12 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC20G8.09c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P87115

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini560 – 694N-acetyltransferaseUniRule annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni626 – 628Acetyl-CoA bindingUniRule annotation3
Regioni633 – 639Acetyl-CoA bindingUniRule annotation7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.UniRule annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000210833

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P87115

KEGG Orthology (KO)

More...
KOi
K14521

Identification of Orthologs from Complete Genome Data

More...
OMAi
VAYGYSN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P87115

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03211 RNA_acetyltr_Nat10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000182 GNAT_dom
IPR007807 Helicase_dom
IPR033688 NAT10
IPR032672 TmcA/NAT10/Kre33
IPR013562 TmcA_N
IPR027992 tRNA_bind_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10925 PTHR10925, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08351 DUF1726, 1 hit
PF13718 GNAT_acetyltr_2, 1 hit
PF05127 Helicase_RecD, 1 hit
PF13725 tRNA_bind_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P87115-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKKALDSRI PTLIKNGCQE KQRSFFVVVG DRARDQVVNL HWLLSQSKVA
60 70 80 90 100
ARPNVLWMYK KDLLGFTSHR KKRENKIKKE IKRGIRDPNS EDPFELFCSI
110 120 130 140 150
TNIRYCYYKE SEKILGQTYG MLVLQDFEAL TPNLLARTIE TVEGGGIVVL
160 170 180 190 200
LLHKLNSLKQ LYTMSMDIHS RYRTEAHSDV TARFNERFIL SLGNCENCLV
210 220 230 240 250
IDDELNVLPI SGGKNVKALP PTLEEDNSTQ NSIKELQESL GEDHPAGALV
260 270 280 290 300
GVTKTLDQAR AVLTFVESIV EKSLKGTVSL TAGRGRGKSA ALGLAIAAAI
310 320 330 340 350
AHGYSNIFIT SPSPENLKTL FEFIFKGFDA LNYEEHVDYD IIQSTNPAYH
360 370 380 390 400
NAIVRVNIFR DHRQTIQYIS PEDSNVLGQA ELVVIDEAAA IPLPLVRKLI
410 420 430 440 450
GPYLVFMAST INGYEGTGRS LSLKLLQQLR EQSRIYSGSG NNKSDSQSHI
460 470 480 490 500
SGRTLKEISL DEPIRYAMGD RIELWLNKLL CLDAASYVSR MATQGFPHPS
510 520 530 540 550
ECSLYRVSRD TLFSYHPISE AFLQRMMSLY VASHYKNSPN DLQLMSDAPA
560 570 580 590 600
HQLFVLLPPV DLKNPKLPDP ICVIQLALEG SISRESIMNS LSRGQRAGGD
610 620 630 640 650
LIPWLISQQF QDENFAALGG ARIVRIAVSP EHVKMGYGTR AMQLLHEYFE
660 670 680 690 700
GKFISASEEF KAVKHSLKRI GDEEIENTAL QTEKIHVRDA KTMPPLLLKL
710 720 730 740 750
SELQPEPLHY VGVSYGLTPS LQKFWKREGY CPLYLRQTAN DLTGEHTCVM
760 770 780 790 800
LRVLEGRDSE WLGAFAQNFY RRFLSLLGYQ FREFAAITAL SVLDACNNGT
810 820 830 840 850
KYVVNSTSKL TNEEINNVFE SYDLKRLESY SNNLLDYHVI VDLLPKLAHL
860 870 880 890 900
YFSGKFPDSV KLSPVQQSVL LALGLQYKTI DTLEKEFNLP SNQLLAMLVK
910 920 930 940 950
LSKKIMKCID EIETKDIEEE LGSNKKTESS NSKLPEFTPL QQSLEEELQE
960 970 980 990 1000
GADEAMLALR EKQRELINAI DLEKYAIRGN EEDWKAAENQ IQKTNGKGAR
1010 1020 1030
VVSIKGEKRK NNSLDASDKK TKEKPSSKKK FRK
Length:1,033
Mass (Da):116,463
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8432B313D818E135
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB08603.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38131

NCBI Reference Sequences

More...
RefSeqi
NP_593326.1, NM_001018757.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC20G8.09c.1; SPAC20G8.09c.1:pep; SPAC20G8.09c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC20G8.09c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB08603.1
PIRiT38131
RefSeqiNP_593326.1, NM_001018757.2

3D structure databases

SMRiP87115
ModBaseiSearch...

Protein-protein interaction databases

BioGridi278978, 12 interactors
STRINGi4896.SPAC20G8.09c.1

PTM databases

iPTMnetiP87115
SwissPalmiP87115

Proteomic databases

MaxQBiP87115
PaxDbiP87115
PRIDEiP87115

Genome annotation databases

EnsemblFungiiSPAC20G8.09c.1; SPAC20G8.09c.1:pep; SPAC20G8.09c
GeneIDi2542520
KEGGispo:SPAC20G8.09c

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.09c
PomBaseiSPAC20G8.09c nat10

Phylogenomic databases

HOGENOMiHOG000210833
InParanoidiP87115
KOiK14521
OMAiVAYGYSN
PhylomeDBiP87115

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P87115

Family and domain databases

HAMAPiMF_03211 RNA_acetyltr_Nat10, 1 hit
InterProiView protein in InterPro
IPR000182 GNAT_dom
IPR007807 Helicase_dom
IPR033688 NAT10
IPR032672 TmcA/NAT10/Kre33
IPR013562 TmcA_N
IPR027992 tRNA_bind_dom
PANTHERiPTHR10925 PTHR10925, 1 hit
PfamiView protein in Pfam
PF08351 DUF1726, 1 hit
PF13718 GNAT_acetyltr_2, 1 hit
PF05127 Helicase_RecD, 1 hit
PF13725 tRNA_bind_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAT10_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P87115
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 16, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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