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UniProtKB - P87110 (ITR2_SCHPO)
Protein
Myo-inositol transporter 2
Gene
itr2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Transporter for myo-inositol.
1 PublicationCatalytic activityi
GO - Molecular functioni
- myo-inositol:proton symporter activity Source: PomBase
GO - Biological processi
- myo-inositol import across plasma membrane Source: PomBase
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Myo-inositol transporter 2 |
Gene namesi | Name:itr2 ORF Names:SPAC20G8.03 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC20G8.03, itr2 |
VEuPathDBi | FungiDB:SPAC20G8.03 |
Subcellular locationi
Other locations
Endoplasmic reticulum
- endoplasmic reticulum Source: PomBase
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 76 | CytoplasmicSequence analysisAdd BLAST | 76 | |
Transmembranei | 77 – 97 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 98 – 99 | ExtracellularSequence analysis | 2 | |
Transmembranei | 100 – 120 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 121 – 123 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 124 – 144 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 145 – 157 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 158 – 178 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 180 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 181 – 201 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 202 – 209 | ExtracellularSequence analysis | 8 | |
Transmembranei | 210 – 230 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 231 – 240 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 241 – 261 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 262 – 367 | ExtracellularSequence analysisAdd BLAST | 106 | |
Transmembranei | 368 – 388 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 389 – 396 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 397 – 417 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 418 – 432 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 433 – 453 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 454 – 468 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 469 – 489 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 490 – 498 | ExtracellularSequence analysis | 9 | |
Transmembranei | 499 – 519 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 520 – 557 | CytoplasmicSequence analysisAdd BLAST | 38 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050454 | 1 – 557 | Myo-inositol transporter 2Add BLAST | 557 |
Proteomic databases
MaxQBi | P87110 |
PaxDbi | P87110 |
PTM databases
iPTMneti | P87110 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 278318, 3 interactors |
STRINGi | 4896.SPAC20G8.03.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 69 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 48 | Basic and acidic residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P87110 |
OMAi | PECGFCA |
PhylomeDBi | P87110 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits |
i Sequence
Sequence statusi: Complete.
P87110-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFNNIPLAT IKSSDDKGKD FIVEMTTRPS ETKKKVPFSE DMREIPSLPN
60 70 80 90 100
EEEANATDPQ ANEVADENGE GFEAEKISSW IWVLSAVAGI SGLLFGYDTG
110 120 130 140 150
VISGALAVLG SDLGHVLSSG QKELITSATS FAALISATTS GWLADWVGRK
160 170 180 190 200
RLLLCADAIF VIGSVIMAAS RNVAMMVVGR FIVGYGIGLT SLIVPMYITE
210 220 230 240 250
LAPARLRGRL VIIYVVFITG GQLIAYSLNA AFEHVHQGWR IMFGIGAAPA
260 270 280 290 300
LGQLISLFWT PESPRYLLRH NHVEKVYKIL SRIHPEAKPA EIAYKVSLIQ
310 320 330 340 350
EGVKVDFPEG NKFQHFFHSL KVLFTVPSNR RSLFIGCFLQ WFQQFSGTNA
360 370 380 390 400
IQYFSAIIFQ SVGFKNSISV SIVVGATNFV FTIVAFMFID RIGRRRILLC
410 420 430 440 450
TSAVMIAGLA LCAIAYHFLP ADTTQNTNSG WQYVVLASII IFLASYASGI
460 470 480 490 500
GNIPWQQAEL FPMEVRALGA GFSTAINWVG NLIISASFLT MMESITPTGT
510 520 530 540 550
FALFAGFCFV GLVTSYFTYP ELAGMSIENI HKLLEKGFWQ AVKESTKRVR
KGRIDEA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 271 | N → H in BAA13913 (PubMed:9501991).Curated | 1 | |
Sequence conflicti | 372 | I → M in BAA13913 (PubMed:9501991).Curated | 1 | |
Sequence conflicti | 428 | N → H in BAA13913 (PubMed:9501991).Curated | 1 | |
Sequence conflicti | 436 | L → I in BAA13913 (PubMed:9501991).Curated | 1 | |
Sequence conflicti | 526 | S → F in BAA13913 (PubMed:9501991).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99105 Genomic DNA No translation available. CU329670 Genomic DNA Translation: CAB08597.1 D89252 mRNA Translation: BAA13913.1 |
PIRi | T38125 T43176 |
RefSeqi | NP_593320.1, NM_001018751.2 |
Genome annotation databases
EnsemblFungii | SPAC20G8.03.1; SPAC20G8.03.1:pep; SPAC20G8.03 |
GeneIDi | 2541827 |
KEGGi | spo:SPAC20G8.03 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99105 Genomic DNA No translation available. CU329670 Genomic DNA Translation: CAB08597.1 D89252 mRNA Translation: BAA13913.1 |
PIRi | T38125 T43176 |
RefSeqi | NP_593320.1, NM_001018751.2 |
3D structure databases
AlphaFoldDBi | P87110 |
SMRi | P87110 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278318, 3 interactors |
STRINGi | 4896.SPAC20G8.03.1 |
PTM databases
iPTMneti | P87110 |
Proteomic databases
MaxQBi | P87110 |
PaxDbi | P87110 |
Genome annotation databases
EnsemblFungii | SPAC20G8.03.1; SPAC20G8.03.1:pep; SPAC20G8.03 |
GeneIDi | 2541827 |
KEGGi | spo:SPAC20G8.03 |
Organism-specific databases
PomBasei | SPAC20G8.03, itr2 |
VEuPathDBi | FungiDB:SPAC20G8.03 |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | P87110 |
OMAi | PECGFCA |
PhylomeDBi | P87110 |
Miscellaneous databases
PROi | PR:P87110 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ITR2_SCHPO | |
Accessioni | P87110Primary (citable) accession number: P87110 Secondary accession number(s): P78901 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families