itr2

Protein namesⁱ	Recommended name: Myo-inositol transporter 2
Gene namesⁱ	Name:itr2 ORF Names:SPAC20G8.03
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome I

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC20G8.03
PomBaseⁱ	SPAC20G8.03 itr2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 76	CytoplasmicSequence analysisAdd BLAST	76
Transmembraneⁱ	77 – 97	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	98 – 99	ExtracellularSequence analysis	2
Transmembraneⁱ	100 – 120	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	121 – 123	CytoplasmicSequence analysis	3
Transmembraneⁱ	124 – 144	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	145 – 157	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	158 – 178	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	179 – 180	CytoplasmicSequence analysis	2
Transmembraneⁱ	181 – 201	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	202 – 209	ExtracellularSequence analysis	8
Transmembraneⁱ	210 – 230	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	231 – 240	CytoplasmicSequence analysis	10
Transmembraneⁱ	241 – 261	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	262 – 367	ExtracellularSequence analysisAdd BLAST	106
Transmembraneⁱ	368 – 388	Helical; Name=8Sequence analysisAdd BLAST	21
Topological domainⁱ	389 – 396	CytoplasmicSequence analysis	8
Transmembraneⁱ	397 – 417	Helical; Name=9Sequence analysisAdd BLAST	21
Topological domainⁱ	418 – 432	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	433 – 453	Helical; Name=10Sequence analysisAdd BLAST	21
Topological domainⁱ	454 – 468	CytoplasmicSequence analysisAdd BLAST	15
Transmembraneⁱ	469 – 489	Helical; Name=11Sequence analysisAdd BLAST	21
Topological domainⁱ	490 – 498	ExtracellularSequence analysis	9
Transmembraneⁱ	499 – 519	Helical; Name=12Sequence analysisAdd BLAST	21
Topological domainⁱ	520 – 557	CytoplasmicSequence analysisAdd BLAST	38

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050454	1 – 557	Myo-inositol transporter 2Add BLAST		557

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P87110
PaxDbⁱ	P87110
PRIDEⁱ	P87110

PTM databases

iPTMnetⁱ	P87110

iPTMnetⁱ

P87110

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	278318, 1 interactor
STRINGⁱ	4896.SPAC20G8.03.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P87110
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMⁱ	HOG000202868
InParanoidⁱ	P87110
KEGG Orthology (KO) More...KOⁱ	K08150
OMAⁱ	EWVEYEM
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C305R
PhylomeDBⁱ	P87110

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P87110-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDFNNIPLAT IKSSDDKGKD FIVEMTTRPS ETKKKVPFSE DMREIPSLPN 
        60         70         80         90        100
EEEANATDPQ ANEVADENGE GFEAEKISSW IWVLSAVAGI SGLLFGYDTG 
       110        120        130        140        150
VISGALAVLG SDLGHVLSSG QKELITSATS FAALISATTS GWLADWVGRK 
       160        170        180        190        200
RLLLCADAIF VIGSVIMAAS RNVAMMVVGR FIVGYGIGLT SLIVPMYITE 
       210        220        230        240        250
LAPARLRGRL VIIYVVFITG GQLIAYSLNA AFEHVHQGWR IMFGIGAAPA 
       260        270        280        290        300
LGQLISLFWT PESPRYLLRH NHVEKVYKIL SRIHPEAKPA EIAYKVSLIQ 
       310        320        330        340        350
EGVKVDFPEG NKFQHFFHSL KVLFTVPSNR RSLFIGCFLQ WFQQFSGTNA 
       360        370        380        390        400
IQYFSAIIFQ SVGFKNSISV SIVVGATNFV FTIVAFMFID RIGRRRILLC 
       410        420        430        440        450
TSAVMIAGLA LCAIAYHFLP ADTTQNTNSG WQYVVLASII IFLASYASGI 
       460        470        480        490        500
GNIPWQQAEL FPMEVRALGA GFSTAINWVG NLIISASFLT MMESITPTGT 
       510        520        530        540        550
FALFAGFCFV GLVTSYFTYP ELAGMSIENI HKLLEKGFWQ AVKESTKRVR 

KGRIDEA

Length:557

Mass (Da):61,137

Last modified:July 1, 1997 - v1

Checksum:ⁱ20875EC11B153175

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	271	N → H in BAA13913 (PubMed:9501991).Curated	1
Sequence conflictⁱ	372	I → M in BAA13913 (PubMed:9501991).Curated	1
Sequence conflictⁱ	428	N → H in BAA13913 (PubMed:9501991).Curated	1
Sequence conflictⁱ	436	L → I in BAA13913 (PubMed:9501991).Curated	1
Sequence conflictⁱ	526	S → F in BAA13913 (PubMed:9501991).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99105 Genomic DNA No translation available. CU329670 Genomic DNA Translation: CAB08597.1 D89252 mRNA Translation: BAA13913.1
PIRⁱ	T38125 T43176
NCBI Reference Sequences More...RefSeqⁱ	NP_593320.1, NM_001018751.2

Genome annotation databases

EnsemblFungiⁱ	SPAC20G8.03.1; SPAC20G8.03.1:pep; SPAC20G8.03
GeneIDⁱ	2541827
KEGGⁱ	spo:SPAC20G8.03

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P87110	MFS myo-inositol transporter		SCHJY		564	UniRef50_P87110
MFS myo-inositol transporter		SCHOY		552
MFS myo-inositol transporter		SCHCR		553

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X99105 Genomic DNA No translation available. CU329670 Genomic DNA Translation: CAB08597.1 D89252 mRNA Translation: BAA13913.1
PIRⁱ	T38125 T43176
RefSeqⁱ	NP_593320.1, NM_001018751.2

3D structure databases

ProteinModelPortalⁱ	P87110
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	278318, 1 interactor
STRINGⁱ	4896.SPAC20G8.03.1

PTM databases

iPTMnetⁱ	P87110

iPTMnetⁱ

P87110

Proteomic databases

MaxQBⁱ	P87110
PaxDbⁱ	P87110
PRIDEⁱ	P87110

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPAC20G8.03.1; SPAC20G8.03.1:pep; SPAC20G8.03
GeneIDⁱ	2541827
KEGGⁱ	spo:SPAC20G8.03

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC20G8.03
PomBaseⁱ	SPAC20G8.03 itr2

Phylogenomic databases

HOGENOMⁱ	HOG000202868
InParanoidⁱ	P87110
KOⁱ	K08150
OMAⁱ	EWVEYEM
OrthoDBⁱ	EOG092C305R
PhylomeDBⁱ	P87110

Enzyme and pathway databases

Reactomeⁱ	R-SPO-429593 Inositol transporters

Reactomeⁱ

R-SPO-429593 Inositol transporters

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P87110

PROⁱ

PR:P87110

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ITR2_SCHPO
Accessionⁱ	P87110Primary (citable) accession number: P87110 Secondary accession number(s): P78901
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	July 1, 1997
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P87110 (ITR2_SCHPO)

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Myo-inositol transporter 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endoplasmic reticulum

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ