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Entry version 163 (29 Sep 2021)
Sequence version 1 (01 Jul 1997)
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Protein

Tip elongation aberrant protein 1

Gene

tea1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex.

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein-membrane adaptor activity Source: PomBase

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tip elongation aberrant protein 1
Alternative name(s):
Altered polarity protein 8
Cell polarity protein tea1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tea1
Synonyms:alp8
ORF Names:SPCC1223.06
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPCC1223.06, tea1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPCC1223.06

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001191461 – 1147Tip elongation aberrant protein 1Add BLAST1147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei503Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P87061

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P87061

PRoteomics IDEntifications database

More...
PRIDEi
P87061

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P87061

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P87061

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Major component of the tea1 cell-end complex.

Interacts with rax2, tea4 and tip1.

Interacts with for3 in the presence of tea4.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
275620, 256 interactors

Protein interaction database and analysis system

More...
IntActi
P87061, 5 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC1223.06.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P87061

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati94 – 144Kelch 1Add BLAST51
Repeati146 – 198Kelch 2Add BLAST53
Repeati199 – 253Kelch 3Add BLAST55
Repeati254 – 303Kelch 4Add BLAST50
Repeati305 – 351Kelch 5Add BLAST47
Repeati355 – 402Kelch 6Add BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 64DisorderedSequence analysisAdd BLAST64
Regioni384 – 403DisorderedSequence analysisAdd BLAST20
Regioni408 – 547DisorderedSequence analysisAdd BLAST140
Regioni538 – 1147Interaction with tea4Add BLAST610
Regioni948 – 1147Retention at microtubule cell endsAdd BLAST200

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili611 – 649Sequence analysisAdd BLAST39
Coiled coili716 – 838Sequence analysisAdd BLAST123
Coiled coili879 – 990Sequence analysisAdd BLAST112
Coiled coili1084 – 1105Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 64Polar residuesSequence analysisAdd BLAST51
Compositional biasi408 – 491Polar residuesSequence analysisAdd BLAST84
Compositional biasi500 – 547Polar residuesSequence analysisAdd BLAST48

Keywords - Domaini

Coiled coil, Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0379, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_275217_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P87061

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNRIKLQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P87061

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011498, Kelch_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01344, Kelch_1, 1 hit
PF07646, Kelch_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00612, Kelch, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281, SSF117281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P87061-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLFKRNKG SAHKPTKPNF SKTSTTPSTS QLKHSHESNV KMSTSTVTEH
60 70 80 90 100
RKKPTGSGSH ITASPWSKLT VRGSSNVLPR YSHASHLYAE GGQEIYIFGG
110 120 130 140 150
VASDSQPKND LWVLNLATSQ FTSLRSLGET PSPRLGHASI LIGNAFIVFG
160 170 180 190 200
GLTNHDVADR QDNSLYLLNT SSLVWQKANA SGARPSGRYG HTISCLGSKI
210 220 230 240 250
CLFGGRLLDY YFNDLVCFDL NNLNTSDSRW ELASVVNDPP PARAGHVAFT
260 270 280 290 300
FSDKLYIFGG TDGANFFNDL WCYHPKQSAW SKVETFGVAP NPRAGHAASV
310 320 330 340 350
VEGILYVFGG RASDGTFLND LYAFRLSSKH WYKLSDLPFT PSPRSSHTLS
360 370 380 390 400
CSGLTLVLIG GKQGKGASDS NVYMLDTSRF RLGSVPTTSG RQRNTSFFSN
410 420 430 440 450
STGNTNPSAF NGLLTSSRIP SYNGSKVRST SHPSRQQYIG SSNSRFNTRH
460 470 480 490 500
QTISTPVSGR ASNDLPSPVV PTRSNSSSIL QPSYNLNSHS SDRRNTNDDD
510 520 530 540 550
QSSLNSQQLS NQAKAQGEVS PTLSFVPSSH SMEQGNGSVA SANNAQSEAA
560 570 580 590 600
TRSINSISEV SEVRFPEQSS VKTVDERKSL DGRITSVTLE TLVEKYSELS
610 620 630 640 650
KQQIVEWFKS KLYEILRDSA SKIDSLTEKL KVANAEKNAA LCEAALEKVP
660 670 680 690 700
LAKHNKLSDG TFSTPDKENV QSTNDAHIMQ ENFSLHKALE VMRETSSDLD
710 720 730 740 750
KQLKDATASQ KELIVQTSSF QKELVEERER HNAISKRLQE IESLYRDREL
760 770 780 790 800
LVTNLEDQLV DQTVTINKFA FERDQFRERS MGFENTIKDL TRKMEATDML
810 820 830 840 850
NVSLHESLRS VQTENSELVT EMALLKAELV KKQAIIDANA NIYDKLTADH
860 870 880 890 900
TNYETVSADI NQNLKETLDK LLNGSSDFKN NEIELLHDQI RITNAKLEKR
910 920 930 940 950
EKLINASKYI EDTLRSEIQE AAEKVSNLEF SNFNLKEENS NMQLQLMKAL
960 970 980 990 1000
EQRNTGAKQL VNLRMQLSTA TSELDMLKLK LRTTALALEE SPDDYSDILS
1010 1020 1030 1040 1050
ILRADMSPFH DLHKQCGVLI DTLNGVKRGF GIFEKKFTDY HKFLENISDK
1060 1070 1080 1090 1100
LKSEEDTSLE TPIHENQSIQ SDQIKEVGEV LSAIKSLSDS VMLLKNQIDD
1110 1120 1130 1140
LAKEKLPLSS SDDEKVNIKE KTDFMKLLVK SGLSNPPAKE PVHDNEN
Length:1,147
Mass (Da):127,436
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BE65F6C666EF4F8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y12709 Genomic DNA Translation: CAA73246.1
CU329672 Genomic DNA Translation: CAA20875.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T40866

NCBI Reference Sequences

More...
RefSeqi
NP_588351.1, NM_001023342.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC1223.06.1; SPCC1223.06.1:pep; SPCC1223.06

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2539047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC1223.06

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12709 Genomic DNA Translation: CAA73246.1
CU329672 Genomic DNA Translation: CAA20875.1
PIRiT40866
RefSeqiNP_588351.1, NM_001023342.2

3D structure databases

SMRiP87061
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi275620, 256 interactors
IntActiP87061, 5 interactors
STRINGi4896.SPCC1223.06.1

PTM databases

iPTMnetiP87061
SwissPalmiP87061

Proteomic databases

MaxQBiP87061
PaxDbiP87061
PRIDEiP87061

Genome annotation databases

EnsemblFungiiSPCC1223.06.1; SPCC1223.06.1:pep; SPCC1223.06
GeneIDi2539047
KEGGispo:SPCC1223.06

Organism-specific databases

PomBaseiSPCC1223.06, tea1
VEuPathDBiFungiDB:SPCC1223.06

Phylogenomic databases

eggNOGiKOG0379, Eukaryota
HOGENOMiCLU_275217_0_0_1
InParanoidiP87061
OMAiWNRIKLQ
PhylomeDBiP87061

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P87061

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011498, Kelch_2
PfamiView protein in Pfam
PF01344, Kelch_1, 1 hit
PF07646, Kelch_2, 1 hit
SMARTiView protein in SMART
SM00612, Kelch, 3 hits
SUPFAMiSSF117281, SSF117281, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEA1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P87061
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: September 29, 2021
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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