UniProtKB - P87058 (LAH1_SCHPO)
Protein
La protein homolog
Gene
sla1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Binds to the precursors of polymerase III RNAs. Functions in tRNA maturation.
GO - Molecular functioni
- RNA strand annealing activity Source: PomBase
- tRNA binding Source: PomBase
GO - Biological processi
- tRNA 3'-end processing Source: CAFA
- tRNA 3'-trailer cleavage, endonucleolytic Source: PomBase
- tRNA 5'-leader removal Source: CAFA
- tRNA folding Source: PomBase
- tRNA processing Source: CAFA
Keywordsi
Molecular function | RNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: La protein homologAlternative name(s): La autoantigen homolog La ribonucleoprotein |
Gene namesi | Name:sla1 Synonyms:lah1 ORF Names:SPAC57A10.10c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC57A10.10c, sla1 |
VEuPathDBi | FungiDB:SPAC57A10.10c |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: CAFA
Other locations
- cytoplasm Source: CAFA
- ribonucleoprotein complex Source: InterPro
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000207607 | 1 – 298 | La protein homologAdd BLAST | 298 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 61 | Phosphoserine1 Publication | 1 | |
Modified residuei | 124 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P87058 |
PaxDbi | P87058 |
PRIDEi | P87058 |
PTM databases
iPTMneti | P87058 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 278030, 38 interactors |
STRINGi | 4896.SPAC57A10.10c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 148 | HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 154 – 236 | RRMPROSITE-ProRule annotationAdd BLAST | 83 |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
HOGENOMi | CLU_043291_1_0_1 |
OMAi | DKFLWTT |
PhylomeDBi | P87058 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit |
i Sequence
Sequence statusi: Complete.
P87058-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTEEQKEEI KDISSKQENS SEVPKAEEAG KVVESQKDTT SEEKKEETTE
60 70 80 90 100
KKEDDGKKDL SFDEAEVLKQ VEFYFSDTNL PHDKFLWTTS QKNDGWVPIQ
110 120 130 140 150
TIANFKRMRR FQPLEAIVNA LRKSPELLEV DEAGEKVRRM IPLVRVDNKS
160 170 180 190 200
VMERSVYCKG FGDEKDDTQI ALEKFFEENA GPISAVRMRR DDDKKFKGSV
210 220 230 240 250
FVEFKEPDVA NKFLEKVKTA PLKWGEDELT IMSKKEYVDM KAELHKNDPP
260 270 280 290
KFSSKRRRFD AFKEMDRQRP GKYSNRGRKF KKQRSSNASE EKPSAASE
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 188 | M → I (PubMed:9404894).Curated | 1 | |
Sequence conflicti | 188 | M → I (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF022949 mRNA Translation: AAB82145.1 AB011371 mRNA Translation: BAA24981.1 CU329670 Genomic DNA Translation: CAB08173.1 |
PIRi | T38937 T43542 |
RefSeqi | NP_593315.1, NM_001018746.2 |
Genome annotation databases
EnsemblFungii | SPAC57A10.10c.1; SPAC57A10.10c.1:pep; SPAC57A10.10c |
GeneIDi | 2541530 |
KEGGi | spo:SPAC57A10.10c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF022949 mRNA Translation: AAB82145.1 AB011371 mRNA Translation: BAA24981.1 CU329670 Genomic DNA Translation: CAB08173.1 |
PIRi | T38937 T43542 |
RefSeqi | NP_593315.1, NM_001018746.2 |
3D structure databases
SMRi | P87058 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 278030, 38 interactors |
STRINGi | 4896.SPAC57A10.10c.1 |
PTM databases
iPTMneti | P87058 |
Proteomic databases
MaxQBi | P87058 |
PaxDbi | P87058 |
PRIDEi | P87058 |
Genome annotation databases
EnsemblFungii | SPAC57A10.10c.1; SPAC57A10.10c.1:pep; SPAC57A10.10c |
GeneIDi | 2541530 |
KEGGi | spo:SPAC57A10.10c |
Organism-specific databases
PomBasei | SPAC57A10.10c, sla1 |
VEuPathDBi | FungiDB:SPAC57A10.10c |
Phylogenomic databases
eggNOGi | KOG0118, Eukaryota |
HOGENOMi | CLU_043291_1_0_1 |
OMAi | DKFLWTT |
PhylomeDBi | P87058 |
Miscellaneous databases
PROi | PR:P87058 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR006630, La_HTH IPR002344, Lupus_La IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR000504, RRM_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF05383, La, 1 hit PF00076, RRM_1, 1 hit |
PRINTSi | PR00302, LUPUSLA |
SMARTi | View protein in SMART SM00715, LA, 1 hit SM00360, RRM, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50961, HTH_LA, 1 hit PS50102, RRM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAH1_SCHPO | |
Accessioni | P87058Primary (citable) accession number: P87058 Secondary accession number(s): O13362, Q10458 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 149 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names